Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injuries, Spasticity, Muscle
Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury
Spasticity is muscle spasms, bouncing (clonus) or stiffness that can negatively impact the quality of life of people with spinal cord injury (SCI).
- Trial name
- NCT04130295
- Testing
- Wearable intensive nerve stimulator
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shepherd Center, Atlanta GA
Spinal Cord Injuries
Effects of the SmartDrive on Mobility, Activity and Shoulder Pain Among People With SCI Using Manual Wheelchairs
This is a prospective study of manual wheelchair users with spinal cord injury (SCI). The users will be their own controls. The primary purpose of the study is to evaluate the ability of the power assist device SmartDrive to…
- Trial name
- NCT04241003
- Testing
- SmartDrive Mx2+
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Permobil, Inc.
Spine Surgery, Excessive Repair
Use of Spinal Sealant System During Spinal Surgery
1. To evaluate the safety and efficacy of the Spinal Sealant as an adjunct to sutured dural repair compared with standard of care methods (control) to obtain watertight dural closure intraoperatively in patients undergoing spinal…
- Conditions
- Spine Surgery, Excessive Repair, Spinal Cord Injuries, Complication of Surgical Procedure
- Trial name
- NCT00458354
- Testing
- Spinal Sealant, Standard Methods of Closing of the Dura
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Spinal Cord Injury
Autologous Mesenchymal Stem Cells in Spinal Cord Injury (SCI) Patients
The aim of this study is to evaluate the use of autologous expanded mesenchymal stem cells intralesional transplantation as a safe and potentially beneficial treatment for patients with spinal cord injury.
- Trial name
- MSC-SCI (NCT01694927)
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Clínica Las Condes. LIT INNOVA CORFO
Spinal Cord Injuries
Autonomic Modulation in Athletes and Non-Athletes With Spinal Cord Injury During Task in Virtual Reality Environment
The study consisted in the analysis of the autonomic modulation of the heart rate by the Heart Rate Variability of the participants at rest for 5 minutes, and during physical activity of 8 minutes, through a virtual reality game.
- Trial name
- NCT04618003
- Testing
- Adaptation of autonomic nervous system to activity in virtual reality
- Where
- Brazil
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Tetraplegia/Tetraparesis, Quadriplegia
UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- UAE-PRIME (NCT06992596)
- Testing
- N1 Implant, R1 Robot
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Neuralink Corp
Spinal Cord Injuries and Disorders (SCI/D), Spinal Cord Injury
Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)
The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections.
- Trial name
- NCT07179822
- Testing
- Motor Evoked Potential (MEP) Operant Conditioning
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injuries
Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity
Study to investigate pharmacodynamic effects and pharmacokinetics of KUC 7483
- Trial name
- NCT02259751
- Testing
- KUC 7483 CL
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Spinal Cord Injury
European Multicentre Study of Human Spinal Cord Injury
Today there is accumulating evidence from animal experiments that regeneration can be induced after a spinal cord injury (SCI). Consequently in the near future, new therapeutic approaches to induce some regeneration will be…
- Trial name
- NCT01571531
- Where
- Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University of Zurich
Spinal Cord Injuries
Self-Management Across the Care Continuum
Persons with spinal cord injury (SCI) face many challenges as they transition from inpatient care to outpatients and on into the community.
- Trial name
- NCT04540679
- Testing
- VIP4SCI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Autonomic Dysreflexia
Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)
This study will be investigating the effects of fesoterodine on autonomic dysreflexia (AD) in patients with spinal cord injuries (SCI).
- Trial name
- NCT02676154
- Testing
- Fesoterodine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Body Weight Support in Spinal Cord Injury
The purpose of this study was to evaluate the effectiveness of body weight-supported treadmill (BWST) training on static balance impairment in adults with incomplete spinal cord injury (SCI) in chronic stage
- Trial name
- NCT02703883
- Testing
- BWST
- Where
- Chile
- Volunteers
- 17 people
- Sponsor
- University of Chile
Spinal Cord Injuries (SCI)
The Impact of Jiaji Electroacupuncture and Scalp Electroacupuncture on Traumatic Spinal Cord Injury
Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden.
- Trial name
- NCT06509841
- Testing
- Electro-acupuncture at the Jiaji points, Electro-acupuncture at the scalp points
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Hangzhou Medical College
Quadriplegia, Spinal Cord Diseases
Upper Extremity Surgery in Spinal Cord Injury
The goal of the investigators work is to establish how nerve transfers can be best used to improve upper extremity function in patients with cervical level spinal cord injury (SCI).
- Conditions
- Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
- Trial name
- NCT01899664
- Testing
- Nerve Transfer Surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Complete Spinal Cord Injuries
Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury
The purpose of this experimental therapy is an assessment of the safety and feasibility of transplantation of autologous olfactory ensheathing glia and olfactory fibroblasts obtained from the olfactory mucosa in patients with…
- Trial name
- NCT01231893
- Testing
- olfactory mucosa ensheathing cell grafting, rehabilitation, rehabilitation
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Wroclaw Medical University
Spinal Cord Injuries, Cervical Spinal Cord Injury
Augmenting Upper Limb Function and Functional Neuroplasticity Using Epidural Stimulation of the Cervical Spinal Cord
This study will test whether spinal stimulation combined with rehabilitation can improve arm and hand function in people with tetraplegia after spinal cord injury. Tetraplegia causes weakness or paralysis in the arms and legs.
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Spinal Cord Injury
- Trial name
- NCT06225245
- Testing
- Epidural Spinal Stimulation (ESS), Upper extremity rehabilitation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Spinal Cord Injury
A Scar Recognition Software for Chronic Spinal Cord Injury (SCI)
To construct and validate a software to recognize scar for patients with chronic SCI based on multimodal MRI.
- Trial name
- NCT04955509
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Peking University Third Hospital
Cervical Spinal Cord Injury, Tetraplegia
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
- Trial name
- NCT06288763
- Where
- 10 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury
Validation of a Novel Robot-aided Assessment of Gait Ability
The aim of this study is the validation of a novel gait assessment method implemented in the Lokomat gait trainer with respect to established clinical gait assessment methods.
- Trial name
- NCT02425332
- Testing
- Lokomat gait trainer
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Hybrid High-intensity Interval Training for Persons With Spinal Cord Injury. A Feasibility Study
This study examines safety and feasibility of a study protocol using a combination of functional electrical legcycling with voluntary armwork (hybrid training) as either skiergometer or armcycling in high intensity intervals for…
- Trial name
- NCT04211311
- Testing
- hybrid high-intensity training
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Southern Denmark
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