Clinical trials: Central Spinal Cord Syndrome
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Spinal Cord Injuries, Traditional Chinese Medicine
Effect of Acupressure on Constipation in Community-dwelling Spinal Cord Injury Patients: a Randomized Controlled Trial
Spinal cord injury is a multi-sensory, motor and autonomic dysfunction, caused by various types of acute and chronic central nervous system injuries. And it will affect patient's ability to live normally and return to society.
- Trial name
- NCT05558657
- Testing
- Home-based, acupressure combined with nursing education, Home-based, manual light touch of the abdomen combined with nursing education
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Spinal Cord Injuries
Seated Balance Using the Indego™
Exoskeleton-assisted walking (EAW) provides a new mobility option and appears to have potential therapeutic benefits for persons with SCI. However, present day technology is not sufficient to replace the wheelchair.
- Trial name
- NCT04047992
- Testing
- Indego™ Exoskeleton
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Neurogenic Bowel
Exoskeleton Neurogenic Bowel Dysfunction Study
The purpose of the study is to assess the effects of exoskeleton training on neurogenic bowel disorders in spinal cord injury/ disease.
- Trial name
- NCT05176327
- Testing
- Exoskeleton training with Ekso NR
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Spinal Cord Injuries and Disorders
Mobile Manual Standing Wheelchair for SCI
People with spinal cord injuries (SCI) are particularly prone to complications from excessive sitting, because many are not able to stand without support.
- Trial name
- MMSW-SCI (NCT04668326)
- Testing
- Manual Standing Wheelchair, Mobile Manual Standing Wheelchair
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?
This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic…
- Trial name
- NCT05467215
- Testing
- Pure oxygen (99%) from Praxair, Edmonton, DIN# 02014408
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spinal Cord Injury, Acute Spinal Cord Injury
Prevention of Bone Loss After Acute SCI by Zoledronic Acid
The overall objective of this study is to define an effective therapeutic approach, using currently available medication, to prevent or mitigate the loss of bone mass and bone strength that occurs after acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02325414
- Testing
- Zoledronic acid
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Spinal Cord Injuries, Complete Spinal Cord Injury
The Efficacy and Safety of a New Power Exoskeleton Robot for Improving Walking Ability in Spinal Cord Injury Patients
In Taiwan, there are more than 23,000 individuals with spinal cord injuries (SCI, mean age: 27 years), with an increment of new 1,200 SCI individuals each year.
- Conditions
- Spinal Cord Injuries, Complete Spinal Cord Injury, Incomplete Spinal Cord Injury
- Trial name
- NCT03548649
- Testing
- exoskeleton robot training
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Spinal Cord Injury
Study to Assess the Validity and Reliability of the Spinal Cord Independence Measure (SCIM III)
In the past two decades there have been great strides made in understanding the biological changes resulting from spinal cord injury (SCI).
- Trial name
- NCT00573976
- Volunteers
- 660 people
- Sponsor
- University of California, Irvine
Spinal Cord Injury/Damage
Body Weight Supported Treadmill Training as Physical Therapy Treatment to Spinal Cord Injury Patients
The purpose of this current prospective study is to assess the effects of body weight support treadmill training (BWSTT) in individuals with spinal cord injury (SCI).
- Trial name
- NCT02031835
- Testing
- BWSTT (3 days a week for maximum of 20 minutes session)
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Ioannina
Spinal Cord Injuries
BioFLO for Respiratory Recovery in SCI
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity.
- Trial name
- NCT06011876
- Testing
- Acute Intermittent Hypoxia (AIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Florida
Spinal Cord Injury(SCI)
Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions
In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury.
- Trial name
- NCT02122276
- Testing
- Ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- Chang Gung University
Spinal Cord Injury, Pressure Ulcers
Pressure Ulcer Prevention for SCI Using a Tele Home Program
NRI research focuses on nursing interventions that are patient-centered, culturally congruent, cost-effective and outcome-driven. High priority populations of interest are veterans with Spinal Cord Injuries (SCI).
- Trial name
- TELEPUPPS (NCT01166828)
- Testing
- TELLEPUPPS
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury
Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury
The research is being done to find out if Functional Electrical Stimulation (FES) stepping can improve the function of people with spinal cord injury that paralyzes.
- Trial name
- NCT01479777
- Testing
- FES Stepping (RT600 from Restorative Therapies, INC.)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Stroke, Spinal Cord Injury
Robotic Assisted Balance and Exoskeleton Training (REACTION) in Neurorehabilitation: a Feasibility Study
The goal of this clinical trial is to explore the effect on walking speed of a new robotic assisted balance and gait trainer (REACTION) and their subsystems in individuals with neurological disorders.
- Trial name
- REACTION (NCT06805500)
- Testing
- REACTION, ABLE Regain, GABLE Core
- Where
- 2 sites in Netherlands
- Volunteers
- 7 people
- Sponsor
- Roessingh Research and Development
Pressure Ulcers, Spinal Cord Injury
BIONs, for Improved Tissue Health and Pressure Sore Prevention
The purpose of this study was to determine the feasibility of an implanted electrical stimulation system incorporating BION microstimulators for long term use to prevent tissue breakdown in high risk patients.
- Trial name
- NCT00262457
- Testing
- Implanted gluteal electrical stimulation system
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Neurologic Disorder, Parkinson Disease
High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive.
- Conditions
- Neurologic Disorder, Parkinson Disease, Spinal Cord Injuries, Spina Bifida
- Trial name
- SHIFT-AR (NCT05951985)
- Testing
- HIFT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Spinal Cord Injuries, Enlarged Prostate With Lower Urinary Tract Symptoms
Exploratory Study Investigating Urodynamic Parameters During Catheterisation
The objective of the study is to explore and understand how urodynamic parameters are affected when emptying the bladder with an intermittent catheter.
- Trial name
- NCT03337048
- Testing
- SpeediCath
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Coloplast A/S
Spinal Cord Injury
Testosterone and Long Pulse Stimulation After SCI
Denervation following spinal cord injury (SCI) limits beneficial application of neuromuscular electrical stimulation (NMES). SCI with denervation results in extensive muscle atrophy that is accompanied with several…
- Trial name
- NCT03345576
- Testing
- Testosterone and LPWS, Testosterone and standard NMES
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Spasticity, Muscle
Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury
Following spinal cord injury (SCI), 75% of patients develop spasticity of the limbs characterized by an increase in muscle tone causing severe pain.
- Conditions
- Spinal Cord Injury, Spasticity, Muscle, Brain Injuries
- Trial name
- SpasT-SCI-T (NCT06532760)
- Testing
- Blood sampling
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
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