Clinical trials: Cephalalgia
Migraine
A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of UB-313 in Healthy Participants
This first in-human (FIH) study of UB-313, an anti-calcitonin gene-related peptide based immunotherapeutic candidate, is designed to assess the safety, tolerability, and immunogenicity of 4 selected UB-313 dose regimens in…
- Trial name
- NCT05477095
- Testing
- UB-313
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vaxxinity, Inc.
Food Sensitivities, Headache
NAET Screening for Food Allergy, Sensitivity and Intolerances Using IgE-Specific Antigen Test and NST- NAET®
Food allergy reactions cause various health disorders in sensitive people. These reactions may be IgE-mediated,cell-mediated, energy disturbance-mediated, or a combination of the three.
- Conditions
- Food Sensitivities, Headache, Backache, Indigestion
- Trial name
- NCT00275795
- Testing
- NAET Procedures
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nambudripad's Allergy Research Foundation
Parturients in Labour
Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients
Headache following accidental dural punction as during epidural analgesia can be severe and sometimes very disabling. The incidence of PDPH is 10-40%, most starting within 48 h of dural puncture.
- Trial name
- AHEAD (NCT01682967)
- Where
- 2 sites in Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Central Sensitisation, Migraine
Presence of Signs of Central Sensitization in Episodic and Chronic Migraine
Nowadays migraine is conceptualized as a continuum, with at the one hand episodic migraine (EM) and at the other hand chronic migraine (CM) (1).
- Trial name
- CENSENMI (NCT05162664)
- Testing
- Pressure pain thresholds, Thermal detection and pain thresholds, Temporal summation
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Ghent
Migraine
Physiopathology, Diagnosis and Therapy of Primary Cephalalgia and Adaptive Disorders
The main aim of the present pilot study is to prove the possibility to use the Nitroglycerin (NTG) model to describe the pathophysiology of headache using task-free advanced Magnetic Resonance Imaging (MRI) techniques, in order…
- Trial name
- NCT04696510
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Postdural Puncture Headache
Examination of Postdural Puncture Headache Frequency, Predisposing Factors and Treatment
Post-dural puncture headache (PDPH) is one of the most important complications of neuraxial blocks and lumbar interventions for cerebrospinal fluid (CSF) examination.
- Trial name
- PDPH (NCT06394024)
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mustafa Soner Ozcan
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Myofascial Trigger Points
A Clinical Observation on Electrophysiology in Headache Patients With Myofascial Trigger Points
Through an observational, cross-sectional study, muscle activity was compared among 21 subjects with episodic headache, 17 subjects with chronic headache and 17 age-matched healthy controls.
- Trial name
- NCT03890393
- Testing
- Electromyography
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Migraine
Medicinal vs. Orthotic Comparison for Migraine Prevention: A Double-Blind Study
To understand the impacts of using a fixed orthotic facial exercise appliance (BLAfit®) for migraine reduction, as compared to medication (fremanezumab-vfrm) and control.
- Trial name
- NCT04547179
- Testing
- Fremanezumab-Vfrm, BLAfit®, Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Manhattan Beach Orthodontics
Face Mask Squeeze
Use of the Mask and Current Pandemic
Due to the continued use of the mask in order to prevent the spread of COVID-19, an impact on people is observed in different areas.
- Trial name
- Mask (NCT04727762)
- Where
- Spain
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Headache
Prostaglandin F2alpha in a Human Headache Model
The hypothesis of this study is that PGF2alpha does not induce headache or dilatation of brain vessels.
- Trial name
- NCT01327118
- Testing
- Prostaglandin F2alpha, Isoton sodium chloride
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Osteoporosis
Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Purpose: NABT: To compare five widely available nitrate formulations: (1) 15 of nitroglycerin (NTG) ointment, (2) 0.3 mg and (3) 0.6 mg of sublingual NTG, (4) 20 mg of isosorbide mononitrate (an oral tablet), and (5) 160 mg of…
- Trial name
- NABT;NABT-B (NCT01387672)
- Testing
- Nitrates (NABT Main trial)
- Where
- Canada
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Mountain Sickness
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness
Acute mountain sickness (AMS) is a common condition that can occur when healthy people travel quickly to high altitude. Typical symptoms include headache, nausea, tiredness, dizziness, and poor sleep.
- Trial name
- NCT07653516
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy
A Study to Compare Zavegepant Concentration Using Samples Collected From the Vein Versus Patient-Centric Microsampling
The purpose of this clinical trial is to learn about the pharmacokinetics and safety of a drug called zavegepant from samples collected using a patient-centric device called Tasso-Plus (for liquid blood sample collection) and…
- Trial name
- NCT05948085
- Testing
- Zavegepant 10 mg IN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Migraine
Study of the Molecular Genetics of Menstrual Migraine
The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approach.
- Trial name
- NCT00904150
- Where
- United Kingdom
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- The City of London Migraine Clinic
Migraine
Study of PK, Safety, and Tolerability of 2 Lots of M207 & Intranasal Zolmitriptan in Healthy Volunteers
This is a single-center, open-label, randomized, 3-way crossover study. Each subject will receive each of the three study treatments once, followed by in-clinic monitoring and extensive blood sample collection for plasma PK…
- Trial name
- NCT04969497
- Testing
- Treatment A: M207 3.8 mg "MiniMac", Treatment B: M207 3.8 mg "MACAP", Treatment C: 5.0 mg Intranasal Zolmitriptan administered at time = 0 and 2 hours post time 0
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zosano Pharma Corporation
Headache Disorders, Primary, Migraine
Trigeminal Brainstem Mapping
To what extent the somatotopy of the 3 branches of the trigeminal nerve (V1,V2,V3) as well as the greater occipital nerve (GON) in the brainstem but also in the thalamus and the insula can be mapped using functional imaging and…
- Trial name
- NCT03999060
- Testing
- Electric Current Stimulation
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Migraine
A Study to Learn About PRT-064040 Nasal Spray in Healthy Adult Subjects
This trial is a Phase I, single-center, randomized, double-blind, placebo-controlled study conducted in healthy Chinese adult subjects.
- Trial name
- NCT07016516
- Testing
- PRT-064040 nasal spray
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sichuan Purity Pharmaceutical Technology Co., Ltd.
Gulf War Illness, Persian Gulf Syndrome
Exercise in Gulf War Illness (GWI)
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional…
- Trial name
- NCT01291758
- Testing
- Submaximal bicycle exercise stress tests performed 24 hr apart
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Georgetown University