Clinical trials: Cephalalgia
Post-Traumatic Headache
Study of Gammacore Sapphire for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)
The purpose of this single-center, prospective, randomized, double-blind, sham controlled, parallel-group study is to collect clinical data related to the safety and efficacy of vagus nerve stimulation for the acute and…
- Trial name
- NCT04071743
- Testing
- gammaCore Sapphire
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Tension-type Headaches
The Efficacy of Lacticum Acidum Homaccord in the Treatment of Chronic Tension-type Headaches
Chronic tension-type headaches (CTTHs) affect 30-40% of the population and account for a number of absences from, and decreased performances at, work and school as well as recreational activities.
- Trial name
- NCT02138474
- Testing
- Lacticum acidum homaccord
- Where
- South Africa
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Headache, Migraine
Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.
- Trial name
- NCT01750723
- Testing
- Acetazolamide
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Borderline Personality Disorder
Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder
Selegiline is superior to placebo in improving psychological and physical functioning in patients with Borderline Personality Disorder.
- Trial name
- NCT01912391
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mood and Anxiety Research, Inc
Headache
Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache
Headache during fasting is a known entity in the scientific literature. The prevalence of such a headache is high and in a study conducted in Israel was found in 60% of people with a previous predilection for headache.
- Trial name
- NCT00752921
- Testing
- etoricoxib
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Trigger Point, Tension-Type Headache
EFFECTS OF MIOFASCIAL RELEASE AND PERCUTANEOUS MICROELETROLYSIS IN TYPE HEADACHE
A headache is a more common disorder and one that prevails over a lifetime of much of the population. Among the causes are in the stress and spasms of the pericranial musculature, presence of painful sensitivity in the region…
- Trial name
- EMRPMITH (NCT03225053)
- Testing
- MEP® technique
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rodrigo Marcel Valentim da Silva
Cluster Headache
Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache
Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing…
- Trial name
- NCT04409977
- Testing
- MRI examination
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine
Use of the Combination of Sumatriptan and Naproxen in the Acute Treatment of Migraine: Real World Evidence Study
This is a multicenter, observational, prospective, real-life study that will be conducted at Headache Centers, aimed at confirming the efficacy and safety of the combination of sumatriptan 85 mg with naproxen 500 mg.
- Trial name
- SMART (NCT06868953)
- Testing
- combination of sumatriptan 85 mg and naproxen 500 mg
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Migraine With and Without Aura, Chronic Migraine
Migraine and Body Composition
This research is being done to look at the association between migraine and obesity.
- Conditions
- Migraine With and Without Aura, Chronic Migraine, Healthy Controls
- Trial name
- NCT01720862
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Migraine Disorders, Migraine Without Aura
1H Magnetic Resonance Spectroscopy in Migraine Patients
To investigate the glutaminergic system in the onset of migraine-like attacks.
- Conditions
- Migraine Disorders, Migraine Without Aura, Headache Disorders, Primary, Headache Disorders
- Trial name
- NCT04220606
- Testing
- Glyceryl trinitrate (I.V. infusion 0.5 µg/kg/min over 20 min)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Migraine
Bioequivalence of Two Tablet Forms of MK0974 (0974-045)
This study will evaluate the bioequivalence of two solid dose formulations of MK0974.
- Trial name
- NCT00965887
- Testing
- MK0974 Ethanolate formulation, Comparator: MK0974 Hydrate formulation
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Headache
The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers
To measure the cerebral hemodynamic effect of L-kynurenine.
- Trial name
- NCT03212430
- Testing
- L-kynurenine
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Post Dural Puncture Headache
"Isometric Lower Limbs Exercises Affect on Cardiac Parameters and Headache in Patient After Spinal Anesthesia"
the Objectives of this clinical trial is : 1. Examine the effect of lower limbs isometric muscle exercises on cardiac parameters in patients after spinal anesthesia. 2.
- Trial name
- LILE-SPA (NCT07547150)
- Testing
- Lower Limb Isometric Exercise
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karbala University
Migraine, Headache
Improvement of Migraine Severity and Frequency With Migraineguard ™
Numerous treatments have been recommended for the prevention of migraine. The purpose of this randomized double-blind placebo controlled trial was to assess the efficacy of MIGRAINEGUARD ™ supplement by Herbacure Natural…
- Trial name
- NCT04759040
- Testing
- Migraineguard
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Herbacure Natural
Migraine Without Aura, Chronic Tension-Type Headache
Cortical Reorganisation in Patients With Primary Headache Disorders
Primary headache disorders are now accepted as physiological diseases, and advanced imaging-techniques have demonstrated a migraine generator in the brain stem and increased stimulus sensitivity in these patients.
- Trial name
- NCT00263991
- Testing
- EEC-techniques
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danish Headache Center
Headache, Tension-Type
A Pharmacokinetic Study of an Experimental Paracetamol Formulation
This PK study is designed to show bioequivalence between the study treatments.
- Trial name
- NCT01476176
- Testing
- Experimental paracetamol, Paracetamol marketed formulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine Disorders, Medication-overuse Headache
Longitudinal Study of the Patients With Medication-overuse Headache or Migraine That Completed Baseline MRI
This is a phone interview research study for patients with migraine or medication-overuse headache (MOH) who have completed baseline MRI scans.
- Trial name
- LMMM (NCT05528081)
- Testing
- Phone interview
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Wei Dai
New Daily Persistent Headache, New Daily Persistent Headache (NDPH)
New Daily Persistent Headache Biomarkers Study
New daily persistent headache is a debilitating syndrome which is seldom researched, poorly understood, and without effective treatments. Chronic migraine is a more common but similarly disabling disorder.
- Trial name
- NDPH (NCT04260087)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Migraine Without Aura, Migraine With Aura
Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study
Evaluation of headache response at 2 hours for active treated attacks for increasing dose.
- Trial name
- NCT01859481
- Testing
- Eletriptan HBr 40 mg, Eletriptan HBr 80 mg
- Where
- 148 sites in Belgium, Czechia and 12 more
- Volunteers
- 971 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer