Clinical trials: Cephalalgia
Migraine
Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)
This is a multicenter, open-label trial to evaluate the efficacy and safety of AXS-07 in subjects with migraine attacks and prior inadequate response to oral CGRP inhibitors.
- Trial name
- NCT05550207
- Testing
- AXS-07 (meloxicam-rizatriptan)
- Where
- 31 sites in United States
- Volunteers
- 100 people
- Sponsor
- Axsome Therapeutics, Inc.
Migraine
Evaluation of a New Treatment for Migraine Attacks
The purpose of this study is to evaluate the efficacy of a novel therapy for treatment of migraine, pain reduction and relief of associated symptoms during ongoing migraine attacks, and presence of a preventive effect post…
- Trial name
- NCT01880671
- Testing
- Inactive Migraine Medical Device, Migraine Medical Device
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska University Hospital
Migraine
A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis
This study will provide additional efficacy data for rizatriptan when used for an acute migraine attack in patients already taking topiramate for migraine prophylaxis.
- Trial name
- NCT00812006
- Testing
- rizatriptan benzoate
- Volunteers
- 108 people
- Sponsor
- Organon and Co
Migraine, Kinesio Taping
The Effectiveness of Cervical Kinesio Taping in Migraine
Migraine is a common episodic headache disorder accompanied by neurological, gastrointestinal and autonomic changes.Migraine symptoms have a wide range, neck pain is seen in most migraine attacks, and accompanying neck pain is…
- Trial name
- NCT06203678
- Testing
- Kinesio taping, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Migraine Disorders
A Study of Combination Product (Sumatriptan Succinate and Naproxen Sodium) in Migraine Subjects Who Report Poor Response or Intolerance to Short Acting Triptans (Study 2 of 2)
This is a randomized, double-blind, placebo-controlled, crossover, two-attack, out-patient, early-intervention evaluation of subjects who have migraine with or without aura and who discontinued use of short acting triptan(s)…
- Trial name
- NCT00382993
- Testing
- Combination Product (sumatriptan succinate/naproxen sodium)
- Where
- 28 sites in United States
- Volunteers
- 169 people
- Sponsor
- GlaxoSmithKline
Headache Versus Non-headache Day
MRA/fMRI Study of Spontaneous Migraine
The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following: Changes in resting state…
- Trial name
- NCT01471314
- Testing
- Headache day versus non-headache day
- Where
- Denmark
- Sponsor
- Glostrup University Hospital, Copenhagen
Migraine Disorders
A Pharmacokinetic Study to Evaluate TREXIMET in Adolescents With Migraine and Healthy Subjects Administered at Three Doses.
This is a pharmacokinetic (PK) study designed to investigate a combination product containing sumatriptan succinate and naproxen sodium administered at 3 single doses (10mg sumatriptan/60mg naproxen sodium, 30mg sumatriptan/180mg…
- Trial name
- NCT00989625
- Testing
- This is a pharmacokinetic study (Treximet)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Post-Dural Puncture Headache
Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean Section
comparison between oral sumatriptan and Nebulized Dexmedetomidine in Post Dural Puncture Headache in Cesarean Section
- Trial name
- NCT06514040
- Testing
- Precedex, Sumatriptan 25 mg
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Migraine
Migraine and CVD Risk in Women
The primary goal of this study is to test the effects of a high-fat, high-carbohydrate mixed meal on candidate modulators of cardiovascular disease risk (inflammation, vascular reactivity, sympathetic nervous system tone, and…
- Trial name
- NCT03081390
- Testing
- Mixed meal tolerance testing, Skin conductance & cold pressor test, Flow-mediated dilation testing
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Migraine Headache
Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache.
Background: Medically intractable chronic migraine (CM) is a disabling illness characterized by headache greater than 15 days per month.
- Trial name
- ONSTIM (NCT00200109)
- Testing
- Occipital Nerve Stimulation
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 110 people
- Sponsor
- MedtronicNeuro
Headache, Stress (Psychology)
The Effectiveness of Acupuncture on Headaches in Women Undergoing IVF Egg Stimulation
To test the effect of acupuncture in treating headaches, as well as co-measures of stress and emotional distress, in participants during the hormonal stimulation phase prior to an oocyte retrieval.
- Conditions
- Headache, Stress (Psychology), Emotional Distress
- Trial name
- NCT07587398
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Yo San University of Traditional Chinese Medicine
Migraine
Treatment for Migraines With an Implantable Device
The purpose of this study is to evaluate the safety and effectiveness of an implantable device for difficult to treat migraine. There are a significant number of patients who have drug refractory migraine and alternative…
- Trial name
- NCT00286078
- Testing
- Precision
- Where
- 15 sites in United States
- Volunteers
- 179 people
- Sponsor
- Boston Scientific Corporation
Post-Craniotomy Headache
ERAS Approach for Post-Craniotomy Headache and Psychological Recovery
This randomized multicenter study involves patients undergoing intracranial surgeries (Population) to evaluate whether a perioperative analgesia protocol including scalp block (SB) with dexmedetomidine (DEX) infusion…
- Trial name
- NCT07510217
- Testing
- Scalp block with 0.5% plain Marcaine, dexmedetomidine, Intraoperative Analgesia
- Where
- Egypt
- Volunteers
- 139 people
- Sponsor
- Tanta University
Episodic Migraine
Study of Sustained Benefit of AMG334 in Adult Episodic Migraine Patients
The purpose of this study is to compare the sustained long-term benefit between two treatment paradigms of migraine prophylactic agents (erenumab versus a control arm of oral prophylactics) in episodic migraine patients who have…
- Trial name
- NCT03927144
- Testing
- AMG334, Oral Prophylactic
- Where
- 112 sites in United States, Argentina and 16 more
- Volunteers
- 621 people
- Sponsor
- Amgen
Migraine
Single Ascending Dose Study to Investigate the Safety and Pharmacokinetics of XC101-D13H in Healthy Adult Subjects
This is a randomized, double-blind, placebo-controlled, parallel-group single ascending dose (SAD) study. There are 4 cohorts of 8 subjects (8 active and 2 placebo) planned for evaluation under fasting conditions.
- Trial name
- NCT04104399
- Testing
- XC101-D13H
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Xoc Pharmaceuticals
Migraine, Magnesium, Pediatric
Serum Magnesium Level and Pediatric Migraine
Aim: The purpose of this study is to compare serum magnesium levels between patients with migraine and a control group and to examine the relationship between the frequency and duration of attacks in patients with migraine and…
- Trial name
- Migraine (NCT06274255)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
Migraine With Aura, Migraine Without Aura
Trial Designs for Evaluating Migraine Treatment
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided.
- Conditions
- Migraine With Aura, Migraine Without Aura, Headache, Migraine
- Trial name
- NCT06617832
- Testing
- Active drug for acute migraine treatment
- Where
- 2 sites in Denmark
- Volunteers
- 128 people
- Sponsor
- University of Aarhus
Migraine Disorders
Sumatriptan and Naratriptan Pregnancy Registry
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age.
- Trial name
- NCT01059604
- Testing
- Sumatriptan, Naratriptan, Sumatriptan-naproxen combination
- Volunteers
- 868 people
- Sponsor
- GlaxoSmithKline
Migraine
MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular Interaction
Migraine is a very common, chronic/intermittent and disabling neurovascular headache disorder that has long believed to have no severe consequences.
- Trial name
- MIBRAIN (NCT01803984)
- Testing
- MRI, EndoPAT, Neuropsychological battery
- Where
- France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Bordeaux
Medication Overuse Headache
An Observation Study on Neuropsychology and Serum Melatonin Level in Patients With Medication Overuse Headache
Medication overuse headache (MOH) is a disabling and costly disorder which is characterized by chronic headache and overuse of different headache medications.
- Trial name
- NCT03655184
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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