Clinical trials: Cephalalgia
Migraine With Aura
Functional MRI and MRA in Migraine With Aura
Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI.
- Trial name
- NCT01388894
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Migraine
A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004)
The purpose of this study is to investigate the efficacy and safety of an MK 0974 for migraine headache and to identify an appropriate dose range for further study.
- Trial name
- NCT00246337
- Testing
- MK0974, Rizatriptan
- Volunteers
- 420 people
- Sponsor
- Merck Sharp & Dohme LLC
Orofacial Pain, Tension-Type Headache
Photobiomodulation Dosimetry s in Patients With Orofacial Pain
This project aims to validate a dosimetry model for photobiomodulation treatment in patients with orofacial pain and tension-type headache symptoms. The study will involve 240 participants divided into four age groups.
- Trial name
- NCT06065969
- Testing
- Photobiomodulation
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Chronic Pain, Trigeminal Neuralgia
Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study
There is a significant debate whether local infiltration techniques may be a method to treat complicated chronic pain syndromes, e.g. refractory headache.
- Conditions
- Chronic Pain, Trigeminal Neuralgia, Cluster Headache, Post-Zoster Neuralgia
- Trial name
- RetroBlock (NCT03066037)
- Testing
- regional-anaesthesiological infiltration
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Charite University, Berlin, Germany
Headache, Migraine
PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers
Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known…
- Trial name
- NCT00291395
- Testing
- PGI2
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Major Depression, Chronic Primary Headache
An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache
Background: Although major depression and chronic headache are strongly associated, there is insufficient evidence on the use of antidepressants for this specific comorbidity.
- Trial name
- NCT00531895
- Testing
- duloxetine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Kraepelin Psiquiatria Clinica
Pain, Postoperative
Effect of the Peri-incisional Multimodal Cocktail Infiltration on Postcraniotomy Headache
Postcraniotomy headache (PCH) has been underestimated for the past decades. However, current treatments for PCH are either considered insufficient or accompanied by severe side-effects.
- Trial name
- NCT03915639
- Testing
- Peri-incisional injection
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Temporomandibular Disorders, Pain
Nasal Carbon Dioxide (CO2)for the Treatment of Temporomandibular Disorders (TMD)Related Pain
This purpose of this study is to evaluate the safety and efficacy of treatment with nasal CO2 in the treatment of pain and other symptoms related to temporomandibular disorder (TMD).
- Conditions
- Temporomandibular Disorders, Pain, Headaches
- Trial name
- NCT00484029
- Testing
- Nasal Carbon Dioxide, Air
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Capnia, Inc.
Migraine
Occipital Nerve Stimulation in the Treatment of Migraine
The objective of this proof-of-concept study is to generate initial safety and effectiveness data for the neuro-modulation stimulation (NMS) E-Box in patients with chronic migraine in an acute setting.
- Trial name
- Verona (NCT01855672)
- Testing
- Stimulation of the Occipital Nerves
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- Ethicon, Inc.
Chronic Migraine, Tension-type Headache
Fire Needling Plus Filiform Needling for Chronic Migraine With Comorbid Tension-Type Headache
The investigators conducted a multicenter, prospective, randomized controlled clinical study to learn whether fire needling combined with filiform needling applied to pericranial muscle tenderness areas can effectively treat…
- Trial name
- NCT07633522
- Testing
- filiform needling, fire needling combined with filiform needling
- Where
- 3 sites in China
- Volunteers
- 88 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Migraine Disorders, Migraine, Classic
Understanding the Pathophysiology of Migraine Pain
Migraine is the most common headache disorder, prevalent in 18% of females and 6% of males. Emergency room visits, physician consults, hospitalizations, medications, and indirect costs such as lost work days and decreased…
- Conditions
- Migraine Disorders, Migraine, Classic, Migraine Without Aura
- Trial name
- NCT03026101
- Testing
- Nitroglycerin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Headache, Headache Disorders
Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Impact Questionnaire
The purpose of this study was to investigate cultural adaptation, reliability and validity of the Turkish version of the Headache Impact Questionnaire (HIQ).
- Conditions
- Headache, Headache Disorders, Headache, Migraine, Headache, Tension
- Trial name
- NCT04765501
- Testing
- Survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Gazi University
Unrecognized Condition
Evaluate DF-003 in ex Vivo Assays Using Peripheral Blood Mononuclear Cell From Subjects With ROSAH Syndrome
Alpha-1 kinase (ALPK1) has been reported as a potential causative gene for ROSAH Syndrome. Genetic variants including T237M have been found in ROSAH Syndrome patients.
- Trial name
- ROSAH (NCT05319132)
- Testing
- Adult subjects with ROSAH syndrome
- Where
- 5 sites in France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Migraine
Prochlorperazine vs Metoclopramide
Migraine headaches are a common reason for patients to present to an emergency department. We are comparing two different medications to see which one is better for patients who present ot an emergency room with a migraine…
- Trial name
- NCT00364806
- Testing
- Prochlorperazine, Metoclopramide
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Montefiore Medical Center
Migraine, Healty Controls
Motor Evoked Potential and Cortical Silent Period in Migraine
The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods.
- Trial name
- NCT07250464
- Testing
- Transcranial Magnetic Stimulation (TMS), Surface Electromyography (sEMG), Needle EMG / Single Motor Unit (SMU) Recording
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Migraine
A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants That Are Not Helped by Previous Preventive Treatments
Evaluation of eptinezumab in the prevention of migraine in participants with unsuccessful prior preventive treatments.
- Trial name
- DELIVER (NCT04418765)
- Testing
- Eptinezumab
- Where
- 138 sites in United States, Belgium and 15 more
- Volunteers
- 892 people
- Sponsor
- H. Lundbeck A/S
Intervention
A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache
This study will assess the efficacy of a neuromodulation device for the treatment of episodic migraine headache.
- Trial name
- NCT02991430
- Testing
- active neuromodulation for episodic migraine headache
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 45 people
- Sponsor
- Scion NeuroStim
Migraine
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to <18 years with episodic migraine.
- Trial name
- NCT05156398
- Testing
- Rimegepant
- Where
- 93 sites in United States, Canada and 5 more
- Volunteers
- 640 people
- Sponsor
- Pfizer
Postdural Puncture Headache, Postoperative Nausea and Vomiting
Ondansetron and Dexamethasone for Prevention of PDPH, Nausea, and Vomiting
This prospective, randomized, double-blind, placebo-controlled study was conducted at the Obstetrics and Gynecology Department of El-Minia University Hospital from October 2018 to October 2019.
- Conditions
- Postdural Puncture Headache, Postoperative Nausea and Vomiting, Obstetric Anesthesia Problems
- Trial name
- PDPH-N/V (NCT07068230)
- Testing
- Ondansetron 8mg, Dexamethasone, Saline
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Temporomandibular Disorder, Orofacial Pain
An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders
Temporomandibular disorders (TMD) encompass a group of conditions involving the masticatory muscles, temporomandibular joint (TMJ), and associated structures.
- Trial name
- NCT07639944
- Testing
- Nerivio treatment
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Theranica
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