Clinical trials: Cephalalgia
Chronic Daily Headache
Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
The objective of this study is to determine if patients with chronic daily headache have continuous headache or moments of headache relief.
- Trial name
- NCT00880425
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Thomas Jefferson University
Pain
Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache
The purpose of this multi-center study is to assess the efficacy of headache relief of new paracetamol/caffeine formulation compared to placebo and ibuprofen in episodic tension-type headache (ETTH).
- Trial name
- NCT01842633
- Testing
- Paracetamol and Caffeine, Ibuprofen
- Where
- United States
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine, With or Without Aura
An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine
This study will evaluate the long-term safety and tolerability of intermittent treatment with ubrogepant for the acute treatment of migraine over 1 year.
- Trial name
- NCT02873221
- Testing
- Ubrogepant, Usual Care
- Where
- 177 sites in United States
- Volunteers
- 1,254 people
- Sponsor
- Allergan
Migraine
A Randomized, Multicenter, Study for the prEvention and Acute Treatment of Migraine (REAL)
This is a randomized study for the prevention and acute treatment of migraine using open label nVNS and standard of care versus standard of care. .
- Trial name
- REAL (NCT03787238)
- Testing
- non-invasive vagus nerve stimulation
- Where
- 17 sites in Denmark, Germany and 3 more
- Sponsor
- ElectroCore INC
Migraine Disorders
An Open-label, Randomized, 3-period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA™ (Sumatriptan Succinate / Naproxen Sodium) Tablet Followed by IMITREX® (Sumatriptan Succinate)
This study will evaluate the exposure of sumatriptan after administration of TREXIMA (sumatriptan 85mg/naproxen sodium 500mg) followed by a subcutaneous IMITREX injection (4mg or 6mg) 2 hours later compared to administration of a…
- Trial name
- NCT00875784
- Testing
- TREXIMA™, IMITREX® (4mg), IMITREX® (6mg)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Headache, Migraine
Sphenopalatine Nerve Block for Headache Tx360
The primary objective of this study is to evaluate the efficacy of sphenopalatine nerve block utilizing the Tx360 (device) to deliver an anesthetic agent (bupivacaine) and to assess the duration of the analgesia.
- Trial name
- NCT01939314
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Indiana University
Menopause, Migraine
The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women
There lacks effective early screen system for the migraine-susceptible women during the peri-menopause period. The processing of acute pain and cognition as well as the underling functional magnetic resonance imaging (fMRI)…
- Trial name
- NCT02820974
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Migraine Headache
A Study to Measure the Safety and Effectiveness of Zonisamide in Subjects With Migraine Headache
The purpose of this study is to determine if zonisamide is effective as a preventative medication for individuals with migraine headache.
- Trial name
- NCT00055484
- Testing
- zonisamide
- Where
- 13 sites in United States
- Volunteers
- 204 people
- Sponsor
- Elan Pharmaceuticals
Headache
Exercise and Manipulative Therapy for Older Persons With Headache
The presence of cervical musculoskeletal impairment is not specific to cervicogenic headache but other various frequent intermittent headache types (i.e. migraine and tension-type headache) in the elderly population.
- Trial name
- NCT01736774
- Testing
- Usual care intervention, Physiotherapy treatment
- Where
- Thailand
- Volunteers
- 65 people
- Sponsor
- Chiang Mai University
Migraine Disorders
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine
This is a clinical trial to assess the efficacy of botox treatment of the sphenopalatine ganglion as an add-on treatment in drug resistant migraine.
- Trial name
- MiBlock (NCT04069897)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Migraine
The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting Nitrogen Oxide (NO) donor.
- Trial name
- NCT02485340
- Testing
- 5-ISMN (isosorbide-5-mononitrate), Sumatriptan
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine With Aura, Migraine Without Aura
Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment
The purpose of this study is to show the efficacy of promethazine in management of patients with moderate to severe migraine
- Trial name
- NCT01814189
- Testing
- Sumatriptan+Promethazine (SPr)
- Where
- Iran
- Volunteers
- 350 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
VICO-trial: Video Consultations in the Follow-up of Children With Functional Abdominal Pain Disorders
The goal of this non-inferiority randomized controlled multi-center trial is to investigate the use of video consultations in the follow-up care of children aged 4 - 18 years old with functional abdominal pain disorders (FAPDs).
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Abdominal Migraine
- Trial name
- VICO (NCT06665867)
- Testing
- Video consultation, Face-to-face consultation
- Where
- Netherlands
- Volunteers
- 208 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Migraine, Headache
Study Using the ShiraTronics Migraine Therapy System
The purpose of this pilot study is to assess the preliminary safety and efficacy of the ShiraTronics Migraine Therapy System in prophylactic treatment of patients with refractory chronic migraine.
- Trial name
- RELIEV-CM (NCT05700318)
- Testing
- neurostimulator
- Where
- 4 sites in Australia
- Volunteers
- 40 people
- Sponsor
- ShiraTronics
Migraine
Efficacy of rTMS in the Treatment of Patients With Migraine
Migraine is a condition thought to be related to cortical hyperexcitability. Repetitive transcranial magnetic stimulation (rTMS) can modulate the cortical excitability by means of long-term potentiation or long-term depression.
- Trial name
- NCT00316979
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hypotension in Pregnant Women, Headache in Pregnant Women
Prediction of Hypotension and Postdural Puncture Headache by Carotid Artery Corrected Flow Time
Anesthesia for cesarean delivery can be provided through general or neuraxial anesthesia (spinal or epidural). Hypotension is a common complication of both methods.
- Trial name
- NCT07372313
- Volunteers
- 90 people
- Sponsor
- TC Erciyes University
Post-spinal Headache
The Effect of Magnesium on Post-spinal Headaches
This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia
- Trial name
- NCT07502482
- Testing
- Magnesium
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Haseki Training and Research Hospital
Vomiting, Migraines
Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS).
- Trial name
- NCT00727974
- Where
- United States
- Volunteers
- 586 people
- Sponsor
- Medical College of Wisconsin
Migraine
Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications
This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications
- Trial name
- NCT05518123
- Testing
- Rimegepant
- Where
- 111 sites in United States, Australia and 12 more
- Volunteers
- 962 people
- Sponsor
- Pfizer
Pain Score (VAS)
Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia
Post-dural puncture headache (PDPH) is a well-recognized and potentially serious complication of subarachnoid block. While advancements in spinal needle design have reduced its incidence in recent years, PDPH still affects a…
- Trial name
- NCT06607861
- Testing
- saline group, dexmedetomidine group, lidocaine group
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Minia University
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