Clinical trials: Cerebral Abnormality
SARS-CoV-2 Infection, Intensive Care Unit Patient
WHO Covid 19 - Neurological Abnormalities in SARS-CoV-2 ICU Patients
The SARS-CoV-2 epidemic is leading to a large number of patients in intensive care units due to severe hypoxemic pneumonia. After an acute phase that may require controlled mechanical ventilation and deep sedation, removal of…
- Conditions
- SARS-CoV-2 Infection, Intensive Care Unit Patient, Neurological Abnormality, Delirium
- Trial name
- NeuroCovid (NCT04643548)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Brain Concussion, Cerebral Concussion
Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED)…
- Conditions
- Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild
- Trial name
- DETECT (NCT02776462)
- Testing
- EyeBox CNS
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Oculogica, Inc.
Minor Head Injury
Outcome of Patients With Mild Head Injury and Presence of an Acute Traumatic Abnormality on CT Scan of Head
Background: Patients with mild blunt traumatic brain injury (TBI) are frequently transferred to Level 1 trauma centers (L1TC) if they have any positive finding of any acute intracranial injury identified on a CT scan of the head.
- Trial name
- NCT04143347
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
PHACE Syndrome
Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies)
1. PHACE syndrome(OMIM database number 606519) is the association of a vascular birthmark (hemangioma) on the face along with one or more of the following conditions: congenital heart defects, congenital anomalies of the cerebral…
- Trial name
- PHACE (NCT01016756)
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Medical College of Wisconsin
Swallowing Disorder, Dysphagia
Sensory Neuromodulation Protocol for the Treatment of Post-stroke Oropharyngeal Dysphagia.
Study design: Multicenter, experimental, randomized, crossed, double blind study (patient and results analysis). Aim: To evaluate the effect of different neurostimulation techniques on the neurophysiological and biomechanical…
- Conditions
- Swallowing Disorder, Dysphagia, Stroke, Neurophysiologic Abnormality
- Trial name
- FIS2014 (NCT04052178)
- Volunteers
- 36 people
- Sponsor
- Hospital de Mataró
Brain
Triage Radiology Imaging Assessment for Greater Effectiveness
The aim of the trial is to understand whether a computerised tool designed to quickly spot problems in brain scans (MIDI) can help doctors diagnose cases faster.
- Trial name
- TRIAGE (NCT07671664)
- Testing
- MIDI
- Volunteers
- 100,800 people
- Sponsor
- King's College London
Bilateral Spastic Cerebral Palsy, Cerebral Palsy
Effect of Treadmill Gait Training Combined With Conventional Physiotherapy on Gait Performance and Functional Mobility in Children With Bilateral Spastic Cerebral Palsy: A Randomized Controlled Trial
Cerebral palsy is a neurological condition that affects movement, muscle control, and walking ability in children. Children with bilateral spastic cerebral palsy often experience increased muscle stiffness, difficulty with…
- Conditions
- Bilateral Spastic Cerebral Palsy, Cerebral Palsy, Spasticity Due to Cerebral Palsy, Gait Abnormality
- Trial name
- GAIT-CP (NCT07683338)
- Testing
- Treadmill Gait Training, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Syeda Khatoon e Jannat Welfare Foundation
Cerebral Palsy, Neurologic Disorder
Post-operative Lite Run Study
Lite Run is a new assistive device that may have FDA listing as a Class I device by mid 2017 based on clinical testing of adults, independent agency testing and in-house evaluations.
- Conditions
- Cerebral Palsy, Neurologic Disorder, Chromosome Abnormality, Spina Bifida
- Trial name
- NCT03135145
- Testing
- Lite Run Gait Trainer, Usual Treatments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Gillette Children's Specialty Healthcare
Intracranial Anomalies, Ultrasound Imaging
AI-Assisted 2D Fetal Brain Ultrasound for Intracranial Anomaly Detection
Timely detection of fetal brain anomalies is critical for improving prenatal counseling and postnatal neurological outcomes. Ultrasonography is the most commonly used and effective imaging method for evaluating fetal structures…
- Conditions
- Intracranial Anomalies, Ultrasound Imaging, Artificial Intelligence
- Trial name
- ALYSSIA (NCT07261618)
- Testing
- Alyssia - AI-Assisted Diagnostic Model for Fetal Brain Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Epilepsy, Rolandic
Association of Processing Speed Dysfunction and Brain Functional Abnormality in ECTS
Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of…
- Trial name
- NCT04954729
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Abnormality in Fetal Heart Rate or Rhythm, Ultrasound
Uterine, Fetal Cerebral Doppler and Oligohydramnios to Predict Abnormal Heart Rate Tracings in Postterm Pregnancies
Objective: To estimate the value of uterine, fetal cerebral Doppler and oligohydramnios to predict abnormal fetal heart rate tracings in pregnancies at or beyond 41 weeks
- Conditions
- Abnormality in Fetal Heart Rate or Rhythm, Ultrasound, Late Pregnancy
- Trial name
- NCT03703037
- Testing
- Ultrasound and Doppler ultrasound
- Where
- Mexico
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Epilepsy; Seizure, Child Development
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
According to estimates by the World Health Organization in 2019, more than 50 million people around the world have epilepsy. Nearly 80% of patients with epilepsy live in developing countries.
- Conditions
- Epilepsy; Seizure, Child Development, Gene Abnormality, Early Onset Disorder
- Trial name
- NCT06278428
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Number 2 Children's Hospital, Ho Chi Minh City
Cognitive Impairment, Cognitive Decline
Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom
- Trial name
- MoCA-Norm (NCT03246269)
- Testing
- MoCA
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Andreas Monsch
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Cardiovascular Diseases, Cardiovascular Abnormality
Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System
To evaluate the Safety and Efficacy of a Novel Biodegradable Occluder for Percutaneous Closure of Patent Foramen Ovale (PFO)
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormality, Heart Defects, Congenital, Heart Septal Defects
- Trial name
- BIOCLOSE-PFO (NCT07300358)
- Testing
- Active Comparator, Experimental
- Volunteers
- 258 people
- Sponsor
- Shanghai Lingsi Medical Technology Co., Ltd.
Central Auditory Processing Disorder, Hearing Impaired (Partially)
A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound
The goal of this clinical trial is to determine the efficacy of Clemastine Fumarate in the presence of engineered sound to treat age-related central auditory processing disorder (CAPD).
- Conditions
- Central Auditory Processing Disorder, Hearing Impaired (Partially), Hearing, Hearing Abnormality
- Trial name
- CAPD-LOOT (NCT07304024)
- Testing
- Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Colorado, Denver
Concussion (Diagnosis), Gait Abnormality
Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery
Approximately 1.6 to 3.8 million mild traumatic brain injuries, or concussions, occur yearly in the United States. Although most individuals progress through return-to-activity (RTA) using symptom-guided aerobic and functional…
- Trial name
- NCT07801482
- Testing
- Exercise, Return to Activity Progression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Illinois University
Alzheimer Dementia, Alzheimer Disease
Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy
The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Delirium Confusional State, Encephalopathy
- Trial name
- NCT07222280
- Testing
- Quest AD-Detect blood test
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Covenant Health, US
Cancer, Cardiac Anomaly
Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses
The purpose of this study is to explain the provision of palliative care at the end of life by the implementation of the ELNEC course, as WBT Program using the Normalization Process Theory, that focus attention on how complex…
- Conditions
- Cancer, Cardiac Anomaly, Cystic Fibrosis, Muscular Dystrophy
- Trial name
- ELNEC-PPC (NCT04461561)
- Testing
- end-of-life nursing education consortium-pediatric palliative care as web based-training plus usual care
- Where
- Iraq
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Altoosi University College
Multiple Sclerosis, Neurophysiologic Abnormality
Investigation The Effect of Conventional Vs. Individualized tDCS Intensity to Achieve Uniform E-Fields
Background: Replications of studies employing transcranial direct stimulation (tDCS) shows great variations in physiological and behavioral outcomes.
- Trial name
- NCT05962281
- Testing
- Transcranial direct current stimulation (tDCS)
- Volunteers
- 30 people
- Sponsor
- Koen Cuypers