Clinical trials: Cerebral Abnormality
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Intellectual Deficiency, Cerebral Abnormality
Corpus Callosum Agenesis and Intellectual Disability
Corpus callosum agenesis or dysgenesis (CCA) is a major brain malformation (˜1/4000 births) presently diagnosed by prenatal ultrasonography.
- Trial name
- ACCREM (NCT02167568)
- Testing
- Genetic
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy
Classification of Cerebral Palsy Subtypes
This study, conducted at the National Institutes of Health and the Children's National Medical Center, will evaluate how well different physicians agree in how they classify cerebral palsy subtypes based on patient examination.
- Trial name
- NCT00072800
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Fetal Anomalies, Brain Malformation
AIRFRAME: Artificial Intelligence for Recognition of Fetal bRain AnoMaliEs at Second Trimester Fetal Brain Scan
Obstetric ultrasound represents the standard of care for the screening of the fetal anomalies. However, its performance is dependent upon several parameters including type of anomaly, gestational age, maternal habitus and skills…
- Trial name
- AIRFRAME (NCT06675266)
- Testing
- Development of AI algorithm for early detection of fetal brain anomalies in the second trimester screening scan
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson Disease, Dystonia
Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia
This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.
- Conditions
- Parkinson Disease, Dystonia, Autonomic Dysreflexia
- Trial name
- NCT03307161
- Testing
- osteopathic manual therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Neural Tube Defects, Spina Bifida, Open
Fetal Endoscopic Surgery for Spina Bifida
This study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.
- Conditions
- Neural Tube Defects, Spina Bifida, Open, Myelomeningocele, Fetal Disease
- Trial name
- FESSB (NCT03315637)
- Testing
- Fetoscopic repair of spina bifida
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Fetal Anomaly
Fetal Brain Ultrasound
The aim of our study is to determine the range of frontal horn sizes (both upside and downside) in healthy fetuses over gestation and to determine how far FHs are from the midline .
- Trial name
- NCT06410391
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Assiut University
Intracranial Hypertension, Abnormality of Intracranial Pressure
Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device
For purposes of validation, this study compares intracranial pressure measurements obtained with a novel self-calibrating, non-invasive, intracranial pressure measuring (ICP) device, with the values obtained from (a) patients in…
- Trial name
- NCT03865576
- Testing
- Non-invasive ICP measurement
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston Neurosciences
Brain Death, Apnea
Apnea Tests as the Methods of Brain Death Diagnosis.
Apnea test (AT) is the most important clinical test performed usually at the end of brain death (BD) diagnosis procedure. Traditional insufflation apnea test (I-AT) cannot be completed in patients with extremely compromised lung…
- Conditions
- Brain Death, Apnea, Pupillary Anomaly
- Trial name
- DiagBD (NCT03281993)
- Testing
- CPAP AT
- Volunteers
- 76 people
- Sponsor
- Pomeranian Medical University Szczecin
Rare Diseases, Genetic Disease
Structural Chromosome Rearrangements and Brain Disorders
The project is focused on the detailed study of structural genomic variants (SVs). Such genetic mutations are in fact alterations in the DNA molecule structure and include copy number variants, inversions and translocations.
- Conditions
- Rare Diseases, Genetic Disease, Chromosome Abnormality
- Trial name
- NCT06072079
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Karolinska Institutet
Schizophrenia, Social Cognition
Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia
There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia.
- Trial name
- NCT01903915
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhage
- Trial name
- NSR-GENE (NCT05361070)
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of California, San Francisco
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Cerebral Hemorrhage, Cerebral Ischemia
Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain Diseases
The goal of this observational study is to compare the differences in the features of cerebral multifrequency EIT(cMFEIT) images between healthy subjects and patients with brain diseases and to explore the possibility of applying…
- Conditions
- Cerebral Hemorrhage, Cerebral Ischemia, Cerebral Edema, Healthy
- Trial name
- NCT05796349
- Testing
- multifrequency EIT-based for detecting intracranial abnormalities
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jieshi Ma
Premature Birth, Neurodevelopmental Disorders
Childhood Outcomes of Preterm Brain Abnormalities
Prematurely born children are at higher risk of cognitive impairments and behavioral disorders than full-term children. There is growing evidence of significant volumetric and shape abnormalities in subcortical structures of…
- Conditions
- Premature Birth, Neurodevelopmental Disorders, Brain Development Abnormality, Brain Lesion
- Trial name
- NCT03410810
- Testing
- MRI, Neurodevelopmental/Neuropsychological Assessment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Infant Development, Hypoglycemia Neonatal
Continuous Glucose Monitoring and Cerebral Oxygenation in Preterm Infants
Neonatal hypoglicaemia is associated with impaired neurodevelopment outcomes in preterm infants. Thus, hypoglicemic events should be diagnosed and treated promptly.
- Conditions
- Infant Development, Hypoglycemia Neonatal, Neurodevelopmental Abnormality
- Trial name
- Glucolight (NCT04347590)
- Testing
- Unblinded - CGM (Medtronic Guardian), Blinded - CGM (Medtronic Guardian)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital Padova
Brain Injuries, Brain Development Abnormality
Evaluating the Efficacy of SyMRI in Clinical Pediatric Populations
Synthetic MR Technologies has created a quantified imaging solution - SyMRI - to enable radiologists to acquire quantified images and always obtain the best contrast images.
- Conditions
- Brain Injuries, Brain Development Abnormality, Brain Pathology
- Trial name
- SyMRI (NCT03494855)
- Testing
- SyMRI Software
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Concussion, Brain
Diffusion Tensor Brain MRI in the Detection of Structural Abnormality of the White Substance in Concussion
Concussions in sports are a major public health problem because of their frequency, and are often underdiagnosed because of an unspecific clinical picture or sometimes masked by the concussion itself.
- Trial name
- COMMOTION (NCT06144359)
- Testing
- specific MRI Acquisition (Diffusion Tensor Imaging) at 3T
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Encephalopathy, Birth Defect
Clinical Utility of Pediatric Whole Exome Sequencing
The investigator aims to examine the clinical utility of WES, including assessment of a variety of clinical outcomes in undiagnosed pediatric cases.
- Conditions
- Encephalopathy, Birth Defect, Intellectual Disability, Multiple Congenital Anomaly
- Trial name
- NCT03525431
- Testing
- Whole Exome Sequencing
- Where
- 4 sites in United States
- Volunteers
- 529 people
- Sponsor
- University of California, San Francisco