Clinical trials: Cerebral Autoregulation
Cardiac Arrest, Cerebral Lesion
Early Transcranial Doppler Goal Directed Therapy After Cardiac Arrest: a Pilot Study
Hypoxic-ischaemic brain injury (HIBI) is the main cause of death in patients who are comatose after resuscitation from cardiac arrest.
- Conditions
- Cardiac Arrest, Cerebral Lesion, Ischemic Encephalopathy, Ischemic Reperfusion Injury
- Trial name
- GOODYEAR (NCT04000334)
- Testing
- MAP increased to optimize cerebral blood flow, MAP between 65 and 85 mmHg
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier le Mans
Transcranial Magnetic Stimulation
Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke
The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
- Trial name
- NCT05843240
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yi Yang
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Lacunar Stroke
The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke.
- Trial name
- LACUNAR_CA (NCT06354881)
- Testing
- Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Leicester
Septic Shock, Cerebral Autoregulation
Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock
The sudy objective is to evaluate the cerebral haemodynamic status in different ranges of systemic arterial pressure in patients with septic shock by noninvasive tools, transcranial doppler and intracranial compliance by…
- Trial name
- NCT05833607
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- D'Or Institute for Research and Education
Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia.
- Conditions
- Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, TBI (Traumatic Brain Injury)
- Trial name
- CAPCOG-TBI (NCT06480838)
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Texas Southwestern Medical Center
Trauma, Brain, Hemorrhage Cerebral
Research of Optimal Cerebral Perfusion Pressure Diagnosis
The research will investigate the hypothesis that timely identification of the optimal value of the cerebral perfusion pressure (optCPP) or optimal arterial blood pressure (optABP) is possible after detecting informative episodes…
- Trial name
- optCPP (NCT06028906)
- Testing
- Multimodal physiological monitoring and cerebral autoregulation monitoring
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Vilnius University
Intraventricular Hemorrhage, Autoregulation
Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage
Annually, almost 5,000 extremely low birth weight (9 ounces to about 2 lbs) infants born in the US survive with severe bleeding in the brain (intraventricular hemorrhage); this devastating complication of prematurity is…
- Trial name
- PhysDis (NCT00665769)
- Testing
- Hypercapnia, Normocapnia
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Baylor College of Medicine
Congenital Heart Disease in Children, Extracorporeal Circulation; Complications
Non-invasive Monitoring of Cerebral Autoregulation in Perioperative Neonatal Cardiac Surgery
Cardiac surgery under extracorporeal circulation (ECC) in newborns with congenital heart disease causes significant morbidity and mortality.
- Trial name
- NEMOCARD (NCT04295239)
- Testing
- MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Cerebral Hemodynamics
Perioperative Cerebrovascular Autoregulation Monitoring in Neurosurgical Patients
One of the challenges in pediatric anesthesiology is to ensure adequate cerebral perfusion pressure to prevent cerebral ischemia or hyperemia from pressure-passive perfusion.
- Trial name
- NCT04174001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
High Altitude Pulmonary Edema
Prevention of High Altitude Pulmonary Edema
A double-blind placebo controlled study To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary edema formation in subjects susceptible to HAPE.
- Trial name
- NCT00274430
- Testing
- dexamethasone 8 mg bid, tadalafil 10mg bid
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Acromegaly, Nonfunctioning Pituitary Tumor
Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors
The purpose of the study is to evaluate the Calcium homeostasis in adult patients with uncontrolled acromegaly. The measurements will be repeated 3-6 months after the treatment of acromegaly (surgical or medical).
- Trial name
- NCT01568359
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Liver Failure, Liver Transplantation
Autoregulation Assessment During Liver Transplantation
Patients with liver failure undergoing liver transplantation often have clinical or sub-clinical encephalopathy that may lead to increased intracranial pressure.
- Conditions
- Liver Failure, Liver Transplantation, Encephalopathy
- Trial name
- NCT01425385
- Testing
- Near infrared spectroscopy monitoring, Autoregulation monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Homeostasis
Observational Study of Electrical Impedance Tomography for Non-Invasive Assessment of Cerebral Autoregulation in Neurocritical Patients
This is a single-center, prospective, observational, self-controlled clinical study conducted at the Neurosurgical Intensive Care Unit of Xijing Hospital, The First Affiliated Hospital of Air Force Military Medical University.
- Trial name
- NCT07602114
- Testing
- Non-invasive cerebral Electrical Impedance Tomography (EIT) monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock
Cerebral Autoregulation in Pediatric ECMO (ECMOX 2)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Cardiogenic Shock, Cardiac Arrest
- Trial name
- ECMO-ECMOX2 (NCT04548739)
- Where
- 4 sites in France, Italy
- Volunteers
- 132 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Obstructive Sleep Apnea Syndrome
Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers
The goal of this trial is to assess the performance of the OxiplexTS-an absolute near-infrared oximeter-as an instrument to measure brain oxygenation and hemodynamics in sleep medicine as well as in the broader field of…
- Trial name
- NIRS-OSAS (NCT00591591)
- Testing
- OxiplexTS
- Where
- 4 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- ISS, Inc.
Delirium
Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction.
- Trial name
- NCT02084394
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Johns Hopkins University