Clinical trials: Cerebral Autoregulation, open to volunteers
Intracranial Pressure, Intracranial Pressure Changes
CoMind Early Feasibility Study
The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around…
- Conditions
- Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage
- Trial name
- CoMind EFS (NCT06368648)
- Where
- 17 sites in United States
- Volunteers
- 581 people
- Sponsor
- CoMind Technologies Limited
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring
This multicenter, prospective, and interventional diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90…
- Trial name
- FACTOR (NCT07747701)
- Testing
- NIRS-based cerebral oxygenation and blood pressure monitoring, Carotid compression test
- Where
- 4 sites in China
- Volunteers
- 227 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cerebral Autoregulation
Feasibility of Using NeuraSignal Transcranial Doppler Robot
The purpose of this study is to determine the feasibility of using the NeuraSignal transcranial doppler robot in a neuro ICU setting to measure cerebral blood flow correlated with arterial blood pressure to generate…
- Trial name
- NCT06565442
- Testing
- NeuraSignal transcranial doppler robot
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Healthy, Autonomic Nervous System
Cardiovascular and Cerebrovascular Control in Healthy Subjects
The aim of the study is to evaluate autonomic function and cerebrovascular control in 60 healthy subjects by means of noninvasive analysis of time series variability.
- Conditions
- Healthy, Autonomic Nervous System, Cerebral Autoregulation
- Trial name
- CardioSan (NCT05706532)
- Testing
- active standing
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation
This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days…
- Trial name
- CAREFUL-CA (NCT07556068)
- Testing
- diagnostic accuracy study
- Where
- 4 sites in China
- Volunteers
- 129 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Cerebral Autoregulation Mapping
Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy
The investigators propose to employ advanced multi-channel near non-invasive near infrared spectroscopy (NIRS) system married with entirely non-invasive continuous arterial blood pressure (niABP) monitor to create a new wearable…
- Trial name
- NCT05433129
- Testing
- Transient hyperemic response, Orthostatic challenge, Vascular chemo-reactivity
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cerebral Autoregulation, Blood Pressure
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically.
- Conditions
- Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
- Trial name
- RICE-DCA (NCT07179887)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Carotid Endarterectomy, Cerebral Autoregulation
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy
Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%.
- Trial name
- NCT06406842
- Testing
- Cerebral oxygenation index guided hemodynamics management
- Where
- 2 sites in China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd