Clinical trials: Cerebral Autoregulation, active
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Carotid Endarterectomy, Cerebral Autoregulation
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy
Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%.
- Trial name
- NCT06406842
- Testing
- Cerebral oxygenation index guided hemodynamics management
- Where
- 2 sites in China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Diabetes Mellitus, Type 1
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)
This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG).
- Trial name
- NCT04387422
- Testing
- Experimental hyperglycemia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Healthy, Autonomic Nervous System
Cardiovascular and Cerebrovascular Control in Healthy Subjects
The aim of the study is to evaluate autonomic function and cerebrovascular control in 60 healthy subjects by means of noninvasive analysis of time series variability.
- Conditions
- Healthy, Autonomic Nervous System, Cerebral Autoregulation
- Trial name
- CardioSan (NCT05706532)
- Testing
- active standing
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Cardiac Arrest (CA)
Integrated Near-Infrared Spectroscopy and Hemodynamic Monitoring for Cerebral Autoregulation in Post-Cardiac Arrest Care Neuroprognostication
Neurological outcome is the primary outcome for post-cardiac arrest patients. Hypoxic-ischemic brain injury is a key element in post-cardiac arrest syndrome, and remains the leading cause of mortality and morbidity in…
- Trial name
- NCT07875348
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Intracerebral Haemorrhage
Ischaemic Lesions in Acute Intracerebral Haemorrhage
The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH).
- Trial name
- CHALLENGE-ICH (NCT06410274)
- Testing
- Transcranial Doppler ultrasonography (TCD)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leicester
Cerebral Oxygenation, Peripheral Oxygenation
Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients
The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in…
- Conditions
- Cerebral Oxygenation, Peripheral Oxygenation, Geriatrics, Ventilation
- Trial name
- NCT07582913
- Testing
- Manual Mask Ventilation, AutoFlow Mechanical Mask Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Ankara City Hospital Bilkent
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Cerebral Autoregulation, Blood Pressure
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically.
- Conditions
- Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
- Trial name
- RICE-DCA (NCT07179887)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cerebral Autoregulation, Near-infrared Spectroscopy
Determination of Blood Pressure Limit of Cerebral Autoregulation During Non-cardiac Surgery in Preterm Infants, Neonates and Term Infants: a Prospective Observational Study Using Near-infrared Spectroscopy Monitoring
This prospective observational study aims to determine the blood pressure range in which cerebral autoregulation is maintained in preterm neonates, preterm infants, term neonates, and term infants undergoing non-cardiac surgery…
- Conditions
- Cerebral Autoregulation, Near-infrared Spectroscopy, Infant, Newborn, General Anesthesia
- Trial name
- NCT07660302
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Intracranial Pressure, Intracranial Pressure Changes
CoMind Early Feasibility Study
The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around…
- Conditions
- Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage
- Trial name
- CoMind EFS (NCT06368648)
- Where
- 17 sites in United States
- Volunteers
- 581 people
- Sponsor
- CoMind Technologies Limited
Intensive Care Unit Syndrome
Cerebral Perfusion Variation During Blood Pressure Changes in ICU
The risk associated with arterial hypotension during anesthesia for intensive care sedation has been demonstrated, but the threshold at which consequences for perfusion of one or more organs appear varies according to the…
- Trial name
- DELTAPAMREA (NCT05804773)
- Testing
- Non-invasive Measurement of cerebral blood velocity in the middle cerebral artery by transcranial pulsed Doppler (TCD) (Mean velocity, Vm, cm/s)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Epilepsy
Lily's Grace Temporal Interference
This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional…
- Trial name
- SLEEP-TIES (NCT07520955)
- Testing
- TES-TI, Structural and Functional MRI
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison