Clinical trials: Cerebral Blood Flow
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT05864950
- Testing
- MRI
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
COPD, Non-invasive Ventilation
NIV Reduces CBF in COPD Patients Without Cognitive Function
Objectives: Investigate the acute NIV effects on CBF and cognitive functions in COPD patients. Methods: Nine non-hypercapnic stable COPD subjects (FEV1/FVC < lower limit of normal) and twelve healthy controls were enrolled.
- Conditions
- COPD, Non-invasive Ventilation, Cognitive Impairment, Cerebral Blood Flow
- Trial name
- NCT03149835
- Testing
- Non-invasive ventilation
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Chronic Fatigue Syndrome
Use of Sildenafil (Viagra) to Alter Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients With CFS
Use of Viagra to Alter Symptoms in Patients with Chronic Fatigue Syndrome (CFS)
- Trial name
- NCT00598585
- Testing
- Sildenafil (Viagra)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Cerebrovascular Function, Cerebral Blood Flow
Mechanistic Effect of Ketones on Cerebral Blood Flow
Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction.
- Trial name
- MEKC (NCT06217159)
- Testing
- Poikilocapnia, Normocapnia
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Healthy
Endothelial Derived Hyperpolarization Factor and Vascular Control
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes.
- Trial name
- NCT05176379
- Testing
- Fluconazole 150 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cognitive Function, Mood
Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or Maintenance
The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood.
- Conditions
- Cognitive Function, Mood, Cerebral Haemodynamics, Caffeine Withdrawal
- Trial name
- NCT01376882
- Testing
- Caffeine
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Brain Blood Flow Impairment
Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Primary study objective: Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort.
- Trial name
- NCT04668261
- Testing
- Advanced imaging investigation
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy Lifestyle, Physical Exercise
Lifestyle and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Healthy Lifestyle, Physical Exercise, Healthy Diet, Cerebrovascular Circulation
- Trial name
- NCT04234009
- Testing
- Healthy Lifestyle
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Persistent Pulmonary Hypertension of Newborn
N-Terminal Pro-brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension
Babies who are suspected of having persistent pulmonary hypertension (PPHN) will be included in this study. PPHN is a condition in which the blood is restricted from flowing to the lungs in a normal way making it hard for babies…
- Trial name
- NCT00443859
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Social Phobia
A Study To Compare Emotional Changes In Subjects With Social Anxiety Disorder
To compare by neuroimaging techniques the way Social Anxiety patients respond to public speaking before and after a drug administration
- Trial name
- NCT00470483
- Testing
- Paroxetine treatment during 8 weeks
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Brain Vascular Disorders, Coronary Artery Disease
Detection of Ultrasound Contrast Signals in the Cerebral Circulation
To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.
- Trial name
- NCT00579241
- Testing
- Ultrasound on Temporal Bone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy Volunteer
Bioequivalence and Food Effect Bioavailability Study of Lumacaftor Film-Coated Tablets
The objective of this study is to assess bioequivalence of lumacaftor from Lumacaftor 200 mg Film-Coated Tablet Formulation (Qanatpharma) versus the reference commercial product, Lumacaftor 200 mg /Ivacaftor 125 mg Combination…
- Trial name
- NCT05968612
- Testing
- Lumacaftor 200 mg/Ivacaftor 125 mg Film-Coated Tablet, Lumacaftor 200 mg Film-Coated Tablet Formulation
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Qanatpharma Canada LTD
Cerebrovascular Regulation
Brain Blood Flow Responses at Rest and During Exercise
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flow to match this.
- Trial name
- NCT06142045
- Testing
- RespirACT RA-MR System
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Alzheimer's Disease
Cerebral and Peripheral Perfusion Pilot Study
The purpose of this study is to evaluate the hypothesis that in middle-aged, asymptomatic, adult children of persons with Alzheimer's disease (AD), atorvastatin therapy will beneficially affect mechanisms thought to contribute to…
- Trial name
- CAPP (NCT00751907)
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Blood Biomarkers from Internal Jugular Vein for the Diagnosis of Alzheimer's Disease
The goal of this observational study is to explore the diagnostic performance of blood biomarkers from the internal jugular vein for the diagnosis of Alzheimer's disease (AD) in patients with cognitive symptoms or concerns.
- Trial name
- NCT06754254
- Testing
- blood biomarkers from the internal jugular vein
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Regional Anesthesia, Horner Syndrome
Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block
The purpose of this study is to assess cerebral blood flow velocity (CBFV) following regional anesthesia for shoulder surgery. The results of this study will help to further understand the physiologic effect of the interscalene…
- Conditions
- Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
- Trial name
- CBF-TCD (NCT04642612)
- Testing
- TCD Measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cerebrovascular Circulation
MRI Biomarkers and Exercise
The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.
- Trial name
- NCT02729428
- Testing
- MRI
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison