Clinical trials: Cerebral Blood Flow
Blood Flow Velocity, Autoregulation
The Effect of an α2-Adrenoceptor Antagonist (Yohimbine) on Dynamic Autoregulation in the Human Middle Cerebral Artery and Ophthalmic Artery
Blood flow autoregulation is defined as the ability of a tissue to maintain a relatively constant flow, despite moderate alterations in perfusion pressure.
- Conditions
- Blood Flow Velocity, Autoregulation, Ocular Physiology
- Trial name
- NCT00814047
- Testing
- Yohimbine hydrochloride
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Polycystic Ovary Syndrome, Exercise
The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
This study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with Polycystic Ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Exercise, Cerebrovascular Circulation
- Trial name
- NCT05394935
- Testing
- High-Intensity Exercise, Moderate-Intensity Exercise
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cardiff Metropolitan University
TIA, Stroke
Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
The research project investigates the incidence of the hyperintense acute reperfusion marker (HARM) in patients with transient ischemic attack (TIA) or transient neurological attack (TNA).
- Conditions
- TIA, Stroke, Ischemia, Diagnoses Disease
- Trial name
- NCT03555643
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Universitätsmedizin Mannheim
Cerebral Small Vessel Diseases
Recovery Improved in Covert Stroke With Exercise
Silent ischemic, also known as "covert stroke vascular disease" (CSVD), contributes to neurological deficits that are caused by damage to small blood vessels in the brain.
- Trial name
- RISE-2 (NCT02068391)
- Testing
- Stretching Program, Exercise Program
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac, Aortic Arch Surgery
Brain Vascular Reactivity to Hypothermic Circulatory Arrest With Antegrade Cerebral Perfusion During Aortic Arch Surgery
Many neonates and infants who undergo complex cardiac surgery are affected by neurological developmental delays. Whilst catastrophic events are immediately identifiable from clinical examination or by macro changes on MRI or CT…
- Conditions
- Cardiac, Aortic Arch Surgery, Brain Vascular, Neonates
- Trial name
- NCT03047876
- Testing
- aortic arch surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Nephrectomy
Changes of Right and Left Cerebral Oxygen Saturation and Blood Flow During Nephrectomy in Lateral Decubitus Position
The purpose of this study is to determine changes of right and left cerebral oxygen saturation and blood flow during nephrectomy in lateral decubitus position.
- Trial name
- NCT01101490
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Traumatic Brain Injury
Effects of Early Skull Repair With Titanium Mesh on Cerebral Blood Flow and Neurological Recovery
To evaluate the feasibility of CT perfusion technique to monitor the changes of blood perfusion in the brain tissue before and after skull repair using titanium mesh.
- Trial name
- NCT03222297
- Testing
- early skull repair, late-stage skull repair
- Volunteers
- 86 people
- Sponsor
- Taihe Hospital
Cognitive Decline
Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Cerebral Blood Flow and Cognitive Function
Scientific studies in humans suggest that diets high in fruit and vegetables may be able to improve some aspects of mental performance such as improving memory and reaction times.
- Trial name
- NCT02381860
- Testing
- 60mL tart Montmorency cherry juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Stroke
Upper Limb Robotic Rehabilitation After Stroke
This is a single arm study aimed at evaluating the acute effects induced by a single session of robot-assisted passive hand mobilization on local perfusion and upper limb function in post-stroke hemiparetic patients.
- Trial name
- NCT03243123
- Testing
- Robotic passive mobilization
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Brescia
Aging Well
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults…
- Trial name
- NCT05131217
- Testing
- Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cardiovascular Diseases, Hypertension
The Impact of Goode Health Beverage on Markers of Physiological and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of daily supplementation of a Good Health beverage on indices of physiological and neurocognitive health.
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet, Healthy
- Trial name
- NCT06245382
- Testing
- Goode Health Beverage, Vanilla Base Beverage Blend
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Aging
Mechanisms of Impaired Brain Blood Flow With Aging
Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into the factors linking advancing age to…
- Trial name
- NCT03775382
- Testing
- Ascorbic Acid, Normal Saline
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Acute Ischemic Stroke
Intra-arterial Methylprednisolone After Successful Endovascular Thrombectomy Anterior Circulation Large Vessel Occlusion
The purpose of IMPACT-LVO trial is to investigate the efficacy and safety of early adjunctive intra-arterial combined with intravenous administration methylprednisolone sodium succinate after successful endovascular thrombectomy…
- Trial name
- IMPACT-LVO (NCT07141303)
- Testing
- The methylprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Tang-Du Hospital
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Function, Mood
Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or Maintenance
The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood.
- Conditions
- Cognitive Function, Mood, Cerebral Haemodynamics, Caffeine Withdrawal
- Trial name
- NCT01376882
- Testing
- Caffeine
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dilated Cardiomyopathy, Thrombosis Cardiac
Intraventricular Stasis In Cardiovascular Disease
This study is designed to quantify the ventricular stasis in patients with different forms of cardiomyopathy and at risk of stroke (ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy) by post-processing…
- Conditions
- Dilated Cardiomyopathy, Thrombosis Cardiac, Stroke, Hypertrophic Cardiomyopathy
- Trial name
- ISBIFLOW (NCT04649034)
- Testing
- Doppler echocardiogram exam, Cardiac magnetic resonance, Brain magnetic resonance
- Where
- 3 sites in Spain
- Volunteers
- 258 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Moyamoya Disease
The Safety and Efficacy of RIC on Adult Moyamoya Disease
There are a series of symptoms such as ischemic stroke、transient ischemic attack 、hemorrhagic stroke、headache 、seizure and so on in moyamoya disease( MMD) patients .Nowadays, revascularization is the only effective way for…
- Trial name
- RIC-AMD (NCT04012268)
- Testing
- RIC, Aspirin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Mood Disorder, Bipolar Disorder
Examination of Brain Serotonin Receptors in Patients With Mood Disorders
The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. This study will also examine how the stress hormone cortisol affects brain function.
- Conditions
- Mood Disorder, Bipolar Disorder, Depression
- Trial name
- NCT00026832
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson Disease, Freezing of Gait
Efficacy of Deep-coil Based Repetitive Transcranial Magnetic Stimulation in the Treatment of Parkinson's Disease With Freezing of Gait and Its Neural Regulation Mechanism Study of Resting-state Cerebral Blood Flow
The protocol for repetitive transcranial magnetic stimulation (rTMS) in treating Parkinson's disease (PD) with freezing of gait (FOG) has not yet established an internationally unified standard, and the heterogeneity of treatment…
- Trial name
- NCT06888778
- Testing
- repetitive transcranial magnetic stimulation (rTMS), Non-stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital