Clinical trials: Cerebral Blood Flows
Acute Ischemic Stroke, Posterior Circulation Brain Infarction
Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions.
- Conditions
- Acute Ischemic Stroke, Posterior Circulation Brain Infarction, Arterial Occlusion Disease
- Trial name
- PC-CBS (NCT07122934)
- Testing
- Assessment of cervico-cerebral arterial occlusion pattern
- Volunteers
- 1,828 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
CSF Leak, CSF Pressure Increased
Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele
Dear Sir or Madam, You have been invited to participate in a clinical study whose aim is to compare the effectiveness of two different approaches to the treatment of cerebrospinal fluid (CSF) pseudomeningocele - conservative…
- Conditions
- CSF Leak, CSF Pressure Increased, CSF Circulation Disorder, Puncture
- Trial name
- PSEUDO (NCT07614399)
- Testing
- Lumbar Drainage, Pseudomeningocele Puncture, Puncture with Fibrin Glue Application
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cerebral Small Vessel Diseases
Recovery Improved in Covert Stroke With Exercise
Silent ischemic, also known as "covert stroke vascular disease" (CSVD), contributes to neurological deficits that are caused by damage to small blood vessels in the brain.
- Trial name
- RISE-2 (NCT02068391)
- Testing
- Stretching Program, Exercise Program
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Vertebral Artery Dissection, Cerebrovascular Accident
Changes in Cerebral Blood Flow With Spinal Manipulative Therapy vs. Voluntary Motion
The investigators are performing a study to determine whether changes in blood flow occur in the neck and back of the brain following a series of head positions and a manipulation of the upper neck.
- Conditions
- Vertebral Artery Dissection, Cerebrovascular Accident, Cerebrovascular Stroke
- Trial name
- NCT01205490
- Testing
- head positions and spinal manipulation
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hemodynamic Instability
An Optical Neuro-monitor of Cerebral Oxygen Metabolism and Blood Flow for Neonatology
Feasibility trial on the use of a hybrid optical device integrating time-resolved near-infrared spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) for measurement of cerebral oxygen metabolism and blood flow in…
- Trial name
- BabyLux (NCT02815618)
- Testing
- BabyLux Neuro-monitor
- Where
- 2 sites in Denmark, Italy
- Volunteers
- 48 people
- Sponsor
- Gorm Greisen
Nephrectomy
Changes of Right and Left Cerebral Oxygen Saturation and Blood Flow During Nephrectomy in Lateral Decubitus Position
The purpose of this study is to determine changes of right and left cerebral oxygen saturation and blood flow during nephrectomy in lateral decubitus position.
- Trial name
- NCT01101490
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Cerebrovascular Function, Cognition
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow.
- Trial name
- NCT05992571
- Testing
- β-OHB
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Functional Magnetic Resonance Imaging
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
This study will identify a dose of ferumoxytol that can reliably detect changes in blood flow/volume in response to non-drug stimuli.
- Trial name
- NCT01244282
- Testing
- fMRI with sensory stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Delirium, Hip Arthroplasty
Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty
The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF)…
- Conditions
- Delirium, Hip Arthroplasty, Elderly
- Trial name
- NCT02818764
- Testing
- Blood Draw, Cerebral Spinal Fluid collection, Electroencephalogram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Pennsylvania
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury
tPBM in Older Adults With Traumatic Brain Injury
The purpose of this study is to evaluate the effect of transcranial photobiomodulation (tPBM) in older patients with chronic traumatic brain injury (TBI).
- Trial name
- NCT06956404
- Testing
- Transcranial photobiomodulator (tPBM)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- NYU Langone Health
Stroke, Ischemic, Intracranial Atherosclerosis
Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling
The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS).
- Trial name
- NCT05623943
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Brain Injuries, Cerebrovascular Disorders
Measuring Blood Flow Characteristics Using Dynamic Contrast Enhanced Magnetic Resonance Imaging
Dynamic contrast-enhanced (DCE) MRI gives quantitative and semi-quantitative information about the integrity of the vascular system and can be used to quantify blood-brain barrier (BBB) integrity.
- Trial name
- NCT02702635
- Testing
- DCE MRI of the brain
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Stroke, Acute Ischemic
EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs
The primary hypothesis being tested in this trial is that ischemic stroke patients in posterior circulation at 4.5 - 24 hours post onset of stroke will have improved clinical outcomes when given intravenous tissue plasminogen…
- Trial name
- NCT05429476
- Testing
- Tissue Plasminogen Activator (Alteplase)
- Where
- 27 sites in China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
High Frequency Oscillation, Volume Targeted Ventilation
Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications.
- Trial name
- NCT06719284
- Testing
- HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order, HFOV at the settings applied prior to the study
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College Hospital NHS Trust
Stroke
MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance.
- Trial name
- MITO (NCT06930638)
- Testing
- Ischemic Conditioning, Antioxidant Supplement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Persistent Pulmonary Hypertension of Newborn
N-Terminal Pro-brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension
Babies who are suspected of having persistent pulmonary hypertension (PPHN) will be included in this study. PPHN is a condition in which the blood is restricted from flowing to the lungs in a normal way making it hard for babies…
- Trial name
- NCT00443859
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Ischemic Stroke
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Posterior Circulation Large Vessel Occlusion Stroke
This is an investigator-initiated phase III clinical trial employing a randomized, double-blind, placebo-controlled design. The primary objective of this study is to investigate the efficacy and safety of an interleukin-6…
- Trial name
- IRIS-3 (NCT07509645)
- Testing
- Tocilizumab
- Where
- 30 sites in China
- Volunteers
- 348 people
- Sponsor
- Capital Medical University
Brain Function, Hemiarch Cardiac Procedure
Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery
The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.
- Trial name
- ACP vs RCP (NCT06986967)
- Testing
- Antegrade Perfusion, Retrograde Perfusion
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University