Clinical trials: Cerebral Blood Flows
Intracranial Aneurysm
Therapeutic Effect of Blood Flow Reconstruction in IVADA
IVADA (Intracranial vertebral artery dissecting aneurysms）is one of the causes of subarachnoid hemorrhage or posterior circulation ischemia with high mortality and disability.
- Trial name
- NCT06134557
- Testing
- conventional stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qilu Hospital of Shandong University
Brain Vascular Function, Cerebral Blood Flow
Soy and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Glucose Metabolism, Cognitive Performance
- Trial name
- NCT03627637
- Testing
- Soy nuts
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Brain Perfusion
Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
This study uses magnetic resonance imaging to determine whether 3 weeks of repeated exposure to Acute Intermittent Hypoxia can improve brain blood flow or blood flow regulation in healthy adults.
- Trial name
- NCT05164705
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Effect on Cerebrovascular Reactivity
The Effect of a Deep-fried Chocolate Bar or Porridge on Cerebral Blood Flow
The deep fried chocolate bar is a snack that the international community strongly associates with Scotland. It has previously been cited as being "a symbol of all that is wrong with the high-fat, high-sugar Scottish diet".
- Trial name
- NCT01918137
- Testing
- chocolate bar, Porridge
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Schizophrenia, Parkinson's Disease
PET Scanning in Parkinson s Disease
This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum…
- Trial name
- NCT00024622
- Testing
- O-15 Water, 18F-Fluoro-L-dopa
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- National Institute of Mental Health (NIMH)
Thrombectomy, Tandem Occlusion
Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion
1. To evaluate whether stent implantation on the ipsilateral extracranial segment, after intracranial thrombectomy successful recanalization compared with balloon angioplasty (eTICI≥2b_50) for acute anterior circulation tandem…
- Conditions
- Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- START (NCT05902000)
- Testing
- Carotid Stenting, Thrombectomy, Dual antiplatelet treatment
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xueli Cai
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cardiovascular Diseases, Hypertension
Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals
The overall research objective of this proposal is to determine the impact of increased daily peanut consumption on indices of neurocognitive and physiological health in BL individuals
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet
- Trial name
- NCT06318377
- Testing
- Peanut group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Acute Spinal Cord Injury, Blood Pressure
TSCS for Acute SCI
This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too…
- Conditions
- Acute Spinal Cord Injury, Blood Pressure, Hypotension
- Trial name
- NCT05305118
- Testing
- TSCS Mapping, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Brain Injuries
Clinical Pilot Study to Evaluate a New Multi-parameter Neuromonitoring Device in Brain-injured Patients
Clinical pilot study to evaluate a new multi-parameter neuromonitoring device that allows the measurement of regional cerebral blood flow (rCBF), intracranial pressure (ICP), brain temperature monitoring and ventricular…
- Trial name
- CBMS FIH (NCT03249220)
- Testing
- Placement of the CBMS Probe
- Where
- 2 sites in Switzerland
- Volunteers
- 1 people
- Sponsor
- Carag AG
Brain Injuries, Traumatic, Cerebrovascular Circulation
CPPopt Guided Therapy: Assessment of Target Effectiveness
Despite improvements in management, mortality in severe traumatic brain injury (TBI) remains 25% and only 40% of patients survive without major handicap.
- Conditions
- Brain Injuries, Traumatic, Cerebrovascular Circulation, Homeostasis
- Trial name
- COGITATE (NCT02982122)
- Testing
- For both groups, CPP targets will be achieved first by ICP control if this is raised and then by ABP support by titration (up or down) of vasopressors and fluids according to local protocols.
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Caffeine
Effects of a Cocoa Shot on the Human Brain 2
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT02080845
- Testing
- no caffeine, high caffeine, no theobromine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Organ Donation After Circulatory Death
Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be…
- Trial name
- NeuroDCD (NCT07698262)
- Where
- 13 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia
Hyperventilation, Aneurysmal Subarachnoid Hemorrhage
Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
Although spontaneous hyperventilation patients with aneurysmal subarachnoid hemorrhage closely associated with poor outcomes, the standard therapy remains unavailable.
- Conditions
- Hyperventilation, Aneurysmal Subarachnoid Hemorrhage, Cerebral Blood Flow
- Trial name
- NCT04940273
- Testing
- Remifentanil Injection [Ultiva]
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
This study aims to evaluate the efficacy and safety of tenecteplase (TNK) intravenous thrombolysis within the extended time window (4.5 to 24 hours) in patients with acute posterior circulation ischemic stroke.
- Trial name
- NCT07094763
- Testing
- TNK plus standard medical treatment, standard medical management
- Where
- China
- Volunteers
- 406 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Aortic Aneurysm
Mild vs Moderate Hypothermic Circulatory Arrest With Unilateral Anterograde Cerebral Perfusion in Hemiarch Replacement
The aim of our study is to analyze the immediate and long-term results between patients undergoing hemiarch replacement with ACP under mild hypothermic (30-32 °C) circulatory arrest versus moderate hypothermic (26-28 °C)…
- Trial name
- NCT04569864
- Testing
- Hypothermic circulatory arrest with unilateral selective anterograde cerebral perfusion
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Fat Processing in the Brain
How Fat Influences the Brain
The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.
- Trial name
- NCT01516021
- Testing
- intake of high or low fat yoghurt
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Dementia
EEG Biofeedback to Improve Memory in Adults With Dementia
This study measures whether the symptoms of frontotemporal dementia (FTD) can be successfully treated by (a) biofeedback training to increase brain blood flow, (b) biofeedback to increase the frequency of the brain's dominant…
- Trial name
- QMFFTD (NCT01168466)
- Testing
- QEEG-based Neurofeedback Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Quietmind Foundation
Ischemic Stroke
The Effect of Low Intensity With BFR on Stroke Patients
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
- Trial name
- NCT07292675
- Testing
- low-intensity resistance training with blood flow restriction, High intensity resistance training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Delta University for Science and Technology
Stroke, Hemiplegia
The Effect of Blood Flow Restriction Training Combined With Transcranial Magnetic Stimulation on Limb Function in Hemiplegic Patients After Stroke
This randomized controlled trial aims to evaluate whether combining blood flow restriction training (BFRT) with repetitive transcranial magnetic stimulation (rTMS) improves limb function in stroke patients with hemiplegia.
- Trial name
- BFR-TMS-Stroke (NCT07454954)
- Testing
- Conventional Rehabilitation, Repetitive Transcranial Magnetic Stimulation (rTMS), Blood Flow Restriction Training (BFRT)
- Volunteers
- 69 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University