Clinical trials: Cerebral Blood Flows
Ischemic Stroke
THE IMPACT- 24M TRIAL (IMPlant Augmenting Cerebral Blood Flow in Mild Strokes Trial 24 Hours From Stroke Onset)
Study Population: Subjects with Mild Acute Ischemic Stroke in the anterior circulation within 24 hours from onset. Study objectives: 1. Identify the personal stimulation level for each patient based on physiological biomarkers 2.
- Trial name
- ImpACT-24M (NCT03551093)
- Testing
- ISS SPG stimulation
- Where
- 4 sites in Georgia
- Volunteers
- 50 people
- Sponsor
- BrainsGate
Regional Anesthesia, Horner Syndrome
Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block
The purpose of this study is to assess cerebral blood flow velocity (CBFV) following regional anesthesia for shoulder surgery. The results of this study will help to further understand the physiologic effect of the interscalene…
- Conditions
- Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
- Trial name
- CBF-TCD (NCT04642612)
- Testing
- TCD Measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alzheimer Disease, Mild Cognitive Impairment
COMMETS- Combination MCI Metabolic Syndrome
The investigators propose a proof of concept RCT (randomized clinical trial), testing the efficacy of intranasal insulin (INI) with semaglutide, a combination therapy with strong biological plausibility to benefit impaired…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Metabolic Syndrome
- Trial name
- NCT06072963
- Testing
- Semaglutide, Intranasal insulin
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Obstructive Sleep Apnea (OSA)
Heart and Brain Blood Flow in Obstructive Sleep Apnea
Obstructive sleep apnea causes repeated pauses in breathing during sleep. Breathing efforts against an occluded airway may change how blood flows through the heart and how blood drains from the brain.
- Trial name
- OSA4DFlow (NCT07913269)
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke, High Intensity Interval Exercise
Blood Flow Response and Acute INterval Exercise
The objective of this project is to study the cerebrovascular response to a single bout of high intensity interval exercise (HIIT) in 25 individuals with chronic stroke compared to 25 age- and sex- matched healthy controls (CON).
- Trial name
- BRAIN (NCT04673994)
- Testing
- Single, acute bout of high intensity interval exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cerebral Oxygenation, Cerebral Blood Flow
Cerebral Near Infrared Spectroscopy During Blood Sampling From a Peripheral Artery Catheter in Preterm Infants
Preterm infants often need peripheral artery catheters for invasive blood pressure recording and to facilitate blood sampling. Near infrared spectroscopy is a method to evaluate cerebral oxygenation and as well as cerebral blood…
- Conditions
- Cerebral Oxygenation, Cerebral Blood Flow, Prematurity
- Trial name
- NCT00926770
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Cologne
Infant, Premature, Diseases, Respiratory Tract Diseases
Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates
A randomized controlled clinical trial evaluates cerebral blood flow changes associated with HFOV-VG in comparison to HFOV alone in preterm neonates with respiratory insufficiency during the period of invasive respiratory support
- Conditions
- Infant, Premature, Diseases, Respiratory Tract Diseases, Cerebral Blood Flow
- Trial name
- NCT05592431
- Testing
- High Frequency Oscillatory Ventilation with Volume Guarantee (SLE6000;SLE), High Frequency Oscillatory Ventilation (SLE6000;SLE)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Organ Transplant
Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant
This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors.
- Trial name
- CONCLUDE (NCT05884736)
- Testing
- Neuromonitoring
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Ischemic Stroke
The Effect of Low Intensity With BFR on Stroke Patients
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
- Trial name
- NCT07292675
- Testing
- low-intensity resistance training with blood flow restriction, High intensity resistance training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Delta University for Science and Technology
Extracorporeal Membrane Oxygenation Complication
Extracorporeal Membrane Oxygenation Evaluated by Transcranial Doppler.
To determine how venoarterial extracorporeal membrane oxygenation (ECMO) affects cerebral blood flow velocity (CBFV) measured by transcranial doppler (TCD), to determine whether specific changes in cerebral blood flow velocity…
- Trial name
- ECMO-DTC (NCT03457090)
- Testing
- Examination : a TCD and Trans-Thoracic Echocardiography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Hypertension
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients
Patients with acute brain injury are at risk for complications such as increased pressure in the brain (intracranial pressure (ICP)), decreased blood flow, bleeding, and brain swelling (cerebral edema).
- Trial name
- NCT01526876
- Testing
- clevidipine butyrate
- Sponsor
- Columbia University
Cognitive Decline
Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Cerebral Blood Flow and Cognitive Function
Scientific studies in humans suggest that diets high in fruit and vegetables may be able to improve some aspects of mental performance such as improving memory and reaction times.
- Trial name
- NCT02381860
- Testing
- 60mL tart Montmorency cherry juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Posterior Circulation Ischemic Stroke
Endovascular Treatment for Posterior Circulation Ischemic Stroke Post 1 Day （24 Hours）
To evaluate the efficacy and safety of endovascular therapy for posterior circulation ischemic stroke presenting more than 24 hours after symptom onset.
- Trial name
- ETP1-PC (NCT07699029)
- Testing
- Endovascular treatment combined with standard pharmacological treatment, Standard pharmacological treatment
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Parkinson' Disease
Blood Flow Restriction and Exercise in Parkinson's Disease
The goal of this clinical trial is to learn whether training with blood flow restriction (BFR), combined with aerobic exercise (performing stepping on a Nu-Step exercise machine), can help improve mobility and other outcomes in…
- Trial name
- BFR-PD (NCT07221994)
- Testing
- Blood flow restriction (BFR) and aerobic exercise via recumbent stepping (Nu-Step)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Francisco
Cerebrovascular Regulation
Brain Blood Flow Responses at Rest and During Exercise
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flow to match this.
- Trial name
- NCT06142045
- Testing
- RespirACT RA-MR System
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Stroke, Cardiac Surgery
Effect of Minimally Invasive Extracorporeal Circulation on Optic Nerve Sheath Diameter and Stroke Incidence in Isolated Open Heart Surgery
This prospective randomized controlled trial compares the effects of Minimally Invasive Extracorporeal Circulation (MiECC) versus conventional cardiopulmonary bypass (CPB) on optic nerve sheath diameter (ONSD) and postoperative…
- Conditions
- Stroke, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- ONSD-MiECC (NCT07661238)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Mental Fatigue, Healthy
The Role of Brain Activation and Cerebral Blood Flow in Mental Fatigue.
To assess the changes in brain activation and cerebral blood flow due to mental fatigue in a placebo-controlled study. More specifically we want to assess whether brain activation [measured with Blood Oxygen Level Dependent…
- Trial name
- NCT03366233
- Testing
- Mental fatigue, Control
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel