Clinical trials: Cerebral Blood Flows
Laparoscopic Surgery
A Comparative Study of Ventilation Strategies in Different Surgical Positions on Intracranial Pressure and Cerebral Blood Flow During Laparoscopic Surgery
The purpose of this clinical trial is to investigate the effects of laparoscopic surgery in the Trendelenburg and Reverse Trendelenburg positions, and variable tidal volume ventilation (V-VCV), pressure-regulated…
- Trial name
- NCT06805747
- Testing
- Variable tidal volume ventilation (V-VCV), Pressure-regulated volume-controlled ventilation (PRVC), Conventional volume-controlled ventilation (C-VCV)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Inner Mongolia Baogang Hospital
Moyamoya Disease
Treatment of Moyamoya Disease With iPSC-derived Exosomes
Moyamoya disease is a cerebrovascular disease clinically characterized by chronic progressive stenosis or occlusion at the ends of bilateral internal carotid arteries and the origin of anterior cerebral arteries and middle…
- Trial name
- NCT07065409
- Testing
- iPSC-EVs
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Huaqiu Zhang
Ischemic Stroke
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of…
- Trial name
- NCT02544087
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Extra Corporeal Membrane Oxygenation, Decanulated Alive
Modeling of Intracerebral Vascularization After Extracorporeal Membrane Oxygenation in Children
Extra corporeal membrane oxygenation (ECMO) is a transient supplementation technique that alleviates hemodynamic and ventilatory failure.
- Trial name
- MoVa-ECMO (NCT05237232)
- Testing
- Magnetic Resonance Angiography (MRA) additional acquisition time, Modeling cerebral vascularization
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Cerebrovascular Accident, Acute Ischemic Stroke
To Assess the Effectiveness and Safety of Catheter-based Focal Intracranial Hypothermia Combined With Endovascular Reperfusion Therapy for Patients With Acute Anterior Circulation Large Artery Occlusion
A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for…
- Conditions
- Acute Cerebrovascular Accident, Acute Ischemic Stroke, Internal Carotid Artery, Middle Cerebral Artery Occlusion
- Trial name
- CHILL-ART (NCT06758609)
- Testing
- Mechanical thrombectomy, 4°C saline infusion, Normothermic saline infusion
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Guangdong Second Provincial General Hospital
Healthy Males, Neuromuscular Function
Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Environmental Stress
Environmental stress, such as low oxygen availability (hypoxia), has been associated with impaired neuromuscular performance; however, the mechanisms associated with these performance decrements remain unclear.
- Trial name
- NCT01830335
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brock University
Hemodynamic Monitoring
Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery
Cardiorespiratory changes during lung resection surgery, even though generally well tolerated, may lead to hemodynamic compromise, reducing venous return to the heart and hence cardiac output.
- Trial name
- NCT07808749
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Acute Ischemic Stroke
Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization
The primary objective of this Phase 2 HASTIER study, as an ancillary study to ICTuS 2, is to compare key imaging measurements for serial changes in recanalization and reperfusion between hypothermia and normothermia treatment…
- Trial name
- HASTIER (NCT01778855)
- Testing
- IV t-PA and normothermia, IV-tPA and hypothermia
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression
This study will compare the effect of three transcranial photobiomodulation (t-PBM) doses (high, middle, and low irradiance) to sham t-PBM on PFC CBF as assessed with fMRI (BOLD) in this multi-center, phase I, double-blinded…
- Trial name
- TRIADE (NCT04366258)
- Testing
- Transcranial Photobiomodulator
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- NYU Langone Health
Parkinson Disease, Orthostatic Hypotension
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension…
- Conditions
- Parkinson Disease, Orthostatic Hypotension, Dysautonomia
- Trial name
- NCT05400174
- Testing
- Tilt table (upright position)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Healthy Volunteer
Studies of Blood Flow to the Brain During Thought
The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.
- Trial name
- NCT00001360
- Where
- United States
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease
Association Between Cerebral Arterial Vascular Flow and Sleep Apnea in Neurodegenerative Alterations
Obstructive sleep apnea syndrome (OSAS) is a sleep-disordered breathing characterized by the occurrence of repeated upper airway obstructions leading to airflow reduction (hypopnea) or cessation (apnea).
- Trial name
- VAAPS (NCT02578303)
- Testing
- Vascular flow measurement by PC-MRI
- Where
- France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Central Hospital Saint Quentin
Healthy Aging, Cognitive Function 1, Social
Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Dementia is one of the leading causes of disability worldwide. Underlying biological mechanisms are crucial in preclinical stages of Alzheimer's disease (AD).
- Conditions
- Healthy Aging, Cognitive Function 1, Social, Cerebrovascular Circulation, Blood Flow
- Trial name
- flADex (NCT06584656)
- Testing
- Aerobic exercise condition, Resistance exercise condition
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Hypertension, Diabetes
Flavanol-Rich Cocoa and Cerebral Blood Flow
The purpose of the study is to learn whether or not cocoa has a beneficial effect on blood flow to the brain in older subjects with diabetes mellitus or hypertension (high blood pressure).
- Trial name
- NCT00825695
- Testing
- cocoa
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Healthy Adults
Acute Effects of Sitting and Physical Activity on Brain Health
The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy…
- Trial name
- NCT04137211
- Testing
- Prolonged sitting with social break, Prolonged sitting with walk break, Prolonged sitting with simple resistance activities
- Where
- Sweden
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Healthy Volunteers
Transcranial Electrical Stimulation (TCES) / Cerebral Blood Flow (CBF) / Xenon Under Computerized Tomography (Xe/CT)
Direct stimulation of the cerebral cortex induces an increase in cerebral blood flow. Although this information is known, it has never been documented during Transcranial Cerebral Electrical Stimulation (TCES), which is a non…
- Trial name
- NCT00273663
- Testing
- TCES
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Lacunar Stroke
The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke.
- Trial name
- LACUNAR_CA (NCT06354881)
- Testing
- Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Leicester
Orthostatic Intolerance
Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury.
- Trial name
- NCT01498809
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia