Clinical trials: Cerebral Blood Flows
Anesthesia, Local, Cerebral Vasospasm
Cervical Sympathetic Block in Patients With Cerebral Vasospasm
The purposes of this study are twofold: 1) to assess the effect of a cervical sympathetic block on cerebral blood flow in patients suffering from cerebral vasospasm, after aneurysmal subarachnoid hemorrhage; 2) to evaluate the…
- Conditions
- Anesthesia, Local, Cerebral Vasospasm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT05230134
- Testing
- Cervical sympathetic block
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Traumatic Brain Injury
Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases.
- Trial name
- NCT04530032
- Testing
- ketogenic/modified Atkins diet, Standard diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Preterm Labor, Cerebral Palsy
Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow
The aim of this study is to investigate the possible use of calcium channel as a neuroprotectant in cases with PTL. This will be done by comparing the effect they have on cerebral blood vessels with the already established MgSo4.
- Trial name
- NCT02591004
- Testing
- Magesium sulphate, Nifedipine, Doppler on fetal middle cerebral artery
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Posterior Circulation Brain Infarction
Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation
There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation.
- Trial name
- CANVAS-II (NCT03317535)
- Testing
- General anesthesia, Local anesthesia/concious sedation, Spontaneous breath
- Where
- 2 sites in China
- Volunteers
- 93 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Large Vessel Occlusion
Mechanical Thrombectomy Blood Flow Reversal
The goal of this study is to reduce the chance of complications during mechanical thrombectomy, which is a procedure to remove blockages from the brain.
- Trial name
- NCT06721338
- Testing
- Mechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MediSys Health Network
Hypotension
Sequential Compression Device (SCD) for Stabilizing Hemodynamics in the Beach Chair Position
This study is a 3-legged randomized study examining whether during shoulder surgery performed in the beach chair position active compressions of the lower leg with a sequential compression device (SCD) have a superior effect on…
- Trial name
- NCT01680393
- Testing
- Sequential compression device, TED stockings
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Social Anxiety Disorder (SAD)
Nefazodone in the Treatment of Social Phobia
The purpose of this study is to determine the effectiveness of nefazadone in patients with social anxiety disorder (SAD).
- Trial name
- NCT00231348
- Testing
- Nefazodone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emory University
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stroke, Stroke, Acute
BELgian CT-perFUSion Study to Select Acute Stroke Patients for Thrombectomy
The goal of this clinical trial is to test whether perfusion CT can be used as a selection tool in stroke patients with a major anterior circulation occlusion, to exclude patients from thrombectomy because of a predicted…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- BELFUS (NCT05685043)
- Testing
- perfusion CT
- Sponsor
- University Hospital, Ghent
Stroke, Acute Ischemic
Tirofiban for Successful Endovascular Stroke Thrombectomy
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization".
- Trial name
- ADJUVANT-2 (NCT06373042)
- Testing
- Intraarterial and intravenous tirofiban
- Volunteers
- 712 people
- Sponsor
- Zhongming Qiu
Healthy
Endothelial Derived Hyperpolarization Factor and Vascular Control
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes.
- Trial name
- NCT05176379
- Testing
- Fluconazole 150 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cerebrovascular Circulation
Blood Flow Measurement Using Quantitative Magnetic Resonance Angiography and Duplex Sonography
The aim of the study is to assess the correlation of blood flow measurement in cervical and intracranial arteries between quantitative magnetic resonance angiography (qMRA) and duplex sonography (DS) and…
- Trial name
- NCT03591523
- Testing
- Quantitative MR angiography, Duplex sonography
- Where
- Czechia
- Volunteers
- 21 people
- Sponsor
- Palacky University
Cerebro-vascular Accident, Exercise
Supplemental Blood Flow Restriction Training to Improve the Upper Extremity in Chronic Stroke
The leading cause of long-term disability worldwide is neurological conditions, with stroke specifically affecting nearly 800,000 individuals in the United States in 2019.
- Conditions
- Cerebro-vascular Accident, Exercise, Blood Flow Restriction (BFR) Training Effects
- Trial name
- NCT07910734
- Testing
- BFR
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Saint Joseph's University, Philadelphia
Fabry Disease, Healthy
PET Scans in Normal Volunteers and Patients With Fabry Disease
This study will determine the rate of sugar metabolism in the brain of patients with Fabry disease, a genetic disease of abnormal lipid metabolism.
- Trial name
- NCT00005111
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aging
Mechanisms of Impaired Brain Blood Flow With Aging
Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into the factors linking advancing age to…
- Trial name
- NCT03775382
- Testing
- Ascorbic Acid, Normal Saline
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Alzheimer Disease, Dementia
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF.
- Trial name
- NCT04692441
- Testing
- Heavy Cream
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Washington
Epilepsy, Depression
Measuring Blood Flow in the Brain After Epileptic Activity
In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT).
- Conditions
- Epilepsy, Depression, Postictal Delirium, Electroconvulsive Therapy
- Trial name
- SYNAPSE (NCT04028596)
- Testing
- Paracetamol, Nimotop
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Autonomic Dysreflexia
Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)
This study will be investigating the effects of fesoterodine on autonomic dysreflexia (AD) in patients with spinal cord injuries (SCI).
- Trial name
- NCT02676154
- Testing
- Fesoterodine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia