Clinical trials: Cerebral Blood Flows
Dementia, Alzheimer Disease
The Cognition and Flow Study
About the research There are currently 850,000 people living with dementia in the United Kingdom. It is now understand that Alzheimer's disease (AzD) can result from damaged blood vessels in the brain.
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Aging
- Trial name
- NCT03656107
- Testing
- Cognitive Training
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Liver Cirrhosis, Hepatic Encephalopathy
Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)
We wish to study patients with liver cirrhosis during and 2 weeks after an acute episode of liver coma (hepatic encephalopathy).
- Trial name
- NCT01151475
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Healthy Volunteer
Caloric Stimulation on Cerebral Blood Flow
This is a prospective, non-randomized study designed to generate preliminary data to assess the effect of a new portable non-invasive caloric stimulator on EEG waveform and cerebral blood flow on normal healthy volunteers.
- Trial name
- NCT01629901
- Testing
- ThermoNeuroModulation (TNM) Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Cerebral Infarct, Neurological Morbidity
Evaluation of Cerebral Parenchymal Changes in Patients Undergoing Proximal Aortic Surgery With Deep Hypothermic Circulatory Arrest Using Diffusion MRI
Deep hypothermic circulatory arrest (DHCA) (18 degree) without cerebral perfusion is a safe technique. Resarchers use this technique in patients with proximal aortic pathologies.
- Conditions
- Cerebral Infarct, Neurological Morbidity, Neurological Complication
- Trial name
- NON (NCT04755439)
- Testing
- DHCA
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute
Cerebral Blood Flow
The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction
This study will enroll 40 subjects aged 18 years or older scheduled for elective surgery under general anesthesia with endotracheal intubation. Basic medical history information will be collected.
- Trial name
- NCT07303985
- Testing
- Remimazolam, Propofol (Group P)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Jun Zhang
Mild Cognitive Impairment
Enhanced External Counterpulsation and Its Effects on Vascular Hemodynamics in Cognitively Impaired Patients
The aim of this study is to investigate whether enhanced external counterpulsation (EECP) therapy for 7 consecutive weeks will improve cerebral blood flow and possibly over time enhance or slow down breakdown of cognitive…
- Trial name
- NCT01659398
- Testing
- External Counterpulsation (EECP)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Patrick Moriarty, MD, FACP, FACC
Intracerebral Haemorrhage
Ischaemic Lesions in Acute Intracerebral Haemorrhage
The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH).
- Trial name
- CHALLENGE-ICH (NCT06410274)
- Testing
- Transcranial Doppler ultrasonography (TCD)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leicester
Alzheimer Disease, Dementia
Evaluation of Age- and Alzheimer's Disease-Related Memory Disorder
The purpose of this study is to examine how a part of the brain called the hippocampus contributes to memory changes that occur with aging and Alzheimer's disease (AD). Memory problems are the most important early symptoms of AD.
- Conditions
- Alzheimer Disease, Dementia, Memory Disorder, Healthy
- Trial name
- NCT00029120
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cerebrovascular Circulation
Blood Brain Flow and Exercise
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults.
- Trial name
- NCT02653638
- Testing
- Control, Indomethacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Stroke
The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Non-stroke Volunteers
This randomized controlled trial investigates the effect of a single dose of glucagon-like peptide-1 (GLP-1) receptor agonist on cerebral blood flow velocity and cortical oxygination in humans without cerebrovascular disease.
- Trial name
- EGRABINS1 (NCT02838589)
- Testing
- Byetta, Isotonic saline
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christina Kruuse
Carotid Artery Stenosis, Superficial Femoral Artery Stenosis
VFI in Healthy Vessels
There is a wealth of evidence implicating the important role of blood flow throughout all stages of the process of atherogenesis.
- Trial name
- NCT05451485
- Testing
- Blood speckle tracking, Ultrasound particle Imaging Velocimetry, 4D flow MRI
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Ischemic Stroke, Acute, Thrombectomy
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process.
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation
- Trial name
- COMET-AIS (NCT05051397)
- Testing
- HYPERCAPNIA, NORMOCAPNIA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Extracorporeal Circulation, Inflammation
Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC)
In this study, the investigators would like to compare a heparin-coated tubing system for minimized extracorporeal circulation (MECC) with the conventional tubing system for MECC, which does not contain heparin coating.
- Conditions
- Extracorporeal Circulation, Inflammation, Blood Coagulation, Intracranial Embolism
- Trial name
- RheoMECC (NCT02321917)
- Testing
- MECC system with rheoparin coating
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obesity
Ingestion of Lipids and Changes in Cerebral Blood Flow of People With Obesity
This study aims to determine changes in cerebral blood flow of people with obesity after the ingestion of fat.
- Trial name
- NCT02079116
- Testing
- 60 grams of fat plus water solution, Pure water
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Aging
Breaks From Sedentary Behavior With Dual Tasks in Elderly
The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people.
- Trial name
- NCT06068374
- Testing
- Break of sedentary behavior with dual task, Break of sedentary behavior with walking
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Stroke, Acute
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM (NCT01585597)
- Testing
- Zoll- Coolgaurd 3000
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Headache Disorders
Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.
- Trial name
- NCT03385174
- Testing
- Carbon monoxide
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Premature Birth, Extremely Low Birth Weight
DCS Study in Extremely Premature Newborns
The researchers are attempting to improve the cerebral monitoring of extremely low gestational age (ELGA) infants, such that in the future, real-time monitoring will be possible, to aid clinicians in management of these infants.
- Conditions
- Premature Birth, Extremely Low Birth Weight, Infant, Small for Gestational Age, Intracerebral Hemorrhage
- Trial name
- NCT04367181
- Testing
- Diffuse Correlation Spectroscopy (DCS), Amplitude Integrated Electroencephalography (aEEG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Maria Angela Franceschini