Clinical trials: Cerebral Blood Flows
Posttraumatic Stress Disorder
Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)
Posttraumatic stress disorder occurs in patients who have experienced, witnessed or have been confronted with an event involving actual death or the threat of death, serious injury, or the threat to physical health and felt fear…
- Trial name
- NCT00001657
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia, Parkinson's Disease
PET Scanning in Parkinson s Disease
This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum…
- Trial name
- NCT00024622
- Testing
- O-15 Water, 18F-Fluoro-L-dopa
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- National Institute of Mental Health (NIMH)
Anesthesia, Peripheral Arterial Diseases
The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery
Anesthesia reduces blood pressure and cerebral blood flow is normally considered to be maintained despite marked changes in blood pressure.
- Trial name
- NCT02531139
- Testing
- MAP maintained at 80 mmHg, MAP maintained at 60 mmHg
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intracranial Aneurysm
Therapeutic Effect of Blood Flow Reconstruction in IVADA
IVADA (Intracranial vertebral artery dissecting aneurysms）is one of the causes of subarachnoid hemorrhage or posterior circulation ischemia with high mortality and disability.
- Trial name
- NCT06134557
- Testing
- conventional stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qilu Hospital of Shandong University
Mild Cognitive Impairment
NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment
This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities.
- Trial name
- NCT03482167
- Testing
- Niagen®
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Delaware
Healthy Males, Neuromuscular Function
The Influence of Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Passive Heat Stress
Increased core temperature (hyperthermia) has been associated with impaired neuromuscular performance; however, the mechanisms associated with these performance decrements and their potential synergies remain unclear.
- Trial name
- NCT01848665
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brock University
Sickle Cell Disease
Voxelotor Brain Oxygenation and Neurocognitive Study
This is an open label, single arm multicenter trial to evaluate the effect of voxelotor treatment on cerebral blood flow (CBF) and neurocognitive function in adolescent and young adult participants (12-30 years of age) with…
- Trial name
- NCT05228821
- Testing
- Voxelotor Oral Tablet
- Where
- 2 sites in United States
- Sponsor
- Pfizer
Arterial Hypotension, Shock
Cerebral Circulation in Critically Ill Children
The principal purpose of this study is to describe the changes in cerebral circulation (assessed by transcranial ultrasound) and oxygenation (assessed by Near InfraRed spectroscopy, NIRS) during resuscitation for hemodynamic…
- Conditions
- Arterial Hypotension, Shock, Cerebral Lesion
- Trial name
- CIRCU-REAPED (NCT03731104)
- Testing
- Near InfraRed Spectroscopy assessment, Transcranial Doppler Ultrasound assessment, Cardiac output assessment
- Where
- 3 sites in France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus, Cerebral Blood Flow
Fasting and Postprandial Cerebral Blood Flow in Type 2 Diabetic Patients
The purpose of this study is to explore the changes of fasting and postprandial cerebral blood flow in patients with type 2 diabetes mellitus.
- Trial name
- NCT04897815
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Functional Blood Flow Disorder
Cerebral Blood Flow During Flexion and Rotation of the Cervical Spine
Rotation or flexion of the cervical spine is unavoidable during positioning for some surgical procedures as carotid endarterectomy, thyroidectomy and surgery of the shoulder.
- Trial name
- TCDPOS (NCT02152488)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Schleswig-Holstein
Ischemic Stroke
Glyburide Advantage in Malignant Edema and Stroke Pilot
The primary objective of this study is to assess the feasibility of enrolling, evaluating, and treating with glyburide for injection severe anterior circulation ischemic stroke participants, whether or not treated with standard…
- Trial name
- GAMES-PILOT (NCT01268683)
- Testing
- Glyburide for Injection
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Ventilation Therapy
Cerebral Blood Flow: Helmet vs Oronasal Mask During Continuous Positive Airway Pressure Ventilation
In this trial the investigators will evaluate blood flow in common carotid artery of healthy subjects treated with Continuous Positive Airway Pressure (CPAP) Ventilation, comparing two different devices: oronasal mask versus…
- Trial name
- NCT06480253
- Testing
- Helmet Continuous Positive Airway Pressure, Oronasal Mask Continuous Positive Airway Pressure
- Where
- Italy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Papa Giovanni XXIII Hospital
Cerebrovascular Accident, Fabry Disease
Vasodilation in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme alpha-galactosidase A. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Conditions
- Cerebrovascular Accident, Fabry Disease, Healthy
- Trial name
- NCT00001774
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Organ Donation After Circulatory Death
Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be…
- Trial name
- NeuroDCD (NCT07698262)
- Where
- 13 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia
Alcohol Consumption, Cerebral Blood Flow
Kudzu Effects on Brain Ethanol Levels: Proton Spectroscopy Assessment
This study is designed to test whether treatment with kudzu extract will increase the rate at which alcohol enters the brain as measured by rapid proton magnetic resonance spectroscopy (1H-MRS).
- Trial name
- Kudzu MRS (NCT01739842)
- Testing
- Kudzu extract
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Pulmonary Hypertension
Noninvasive Determination of Cerebral Tissue Oxygenation in Pulmonary Hypertension
To study the effect of acute pulmonary vasodilatation on cerebral tissue oxygenation (CTO) and cerebral blood flow (CBF) as indicator for cerebrovascular autoregulation in comparison to the effects of supplemental oxygen…
- Trial name
- NCT01463514
- Testing
- Right heart catheterization, Near-infrared spectroscopy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Cardiovascular Diseases, Hypertension
The Impact of Goode Health Beverage on Markers of Physiological and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of daily supplementation of a Good Health beverage on indices of physiological and neurocognitive health.
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet, Healthy
- Trial name
- NCT06245382
- Testing
- Goode Health Beverage, Vanilla Base Beverage Blend
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cognitive and Cerebral Blood Flow Effects of Resveratrol
The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO).
- Trial name
- NCT01010009
- Testing
- Trans- resveratrol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Stroke, Acute Ischemic
Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)
The effect of head position as a nonpharmacological therapy on acute ischemic stroke (AIS) remains inconclusive. Recent HOPES2 (Head dOwn-Position for acutE moderate ischemic Stroke with large artery atherosclerosis) suggest the…
- Trial name
- NCT06010641
- Testing
- head-down position
- Where
- China
- Volunteers
- 600 people
- Sponsor
- General Hospital of Shenyang Military Region
Cognitive Change
Acute Dose-ranging Effects of Mango Leaf Extract (Zynamite® 15%) on Cognitive Function and Cerebral Blood Flow
Zynamite® is a novel mango (Mangifera indica) leaf extract standardized to contain polyphenol mangiferin.It has previously been shown to enhance brain oxygenation, physical performance and ergogenic parameters following…
- Trial name
- NCT05580146
- Testing
- Zynamite® 15% 150mg, Zynamite® 15% 300mg, Zynamite® 15% 600mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Northumbria University