Clinical trials: Cerebral Blood Flows
Cardiovascular Diseases, Cerebral Anoxia
Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest
To compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.
- Conditions
- Cardiovascular Diseases, Cerebral Anoxia, Cerebrovascular Disorders, Defect, Congenital Heart
- Trial name
- BCAS (NCT00000470)
- Testing
- cardiac surgical procedures, cardiopulmonary bypass
- Volunteers
- 171 people
- Sponsor
- Boston Children's Hospital
Drug Dependence
Brain Function in Response to Motivational Stimuli
This study seeks more information about the biology of substance dependency by exploring the brain areas involved in feeling positive and negative emotions.
- Trial name
- NCT00047866
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Brain Vascular Function, Cerebral Blood Flow
Mixed Nuts and Brain Vascular Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Trial name
- NCT04210869
- Testing
- Mixed Nuts
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sleep
MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle
This study will investigate the spatio-temporal characteristics of brain activity during sleep. Functional magnetic resonance imaging (fMRI) studies have shown that in the absence of external stimuli, the brain continues to show…
- Trial name
- NCT00117221
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Brain Injuries
Early Mobilisation After Severe Traumatic Brain Injury
Increasing focus on the negative effects of bed rest have become more apparent in the intensive care unit within the last decade.
- Trial name
- NCT02924649
- Testing
- Early Intensive mobilisation
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Amblyopia, Regional Blood Flow
Amblyopia and Neurovascular Coupling in the Retina of Humans
The visual disorder of amblyopia affects 2% to 3% of the population. Amblyopia is a developmental condition that is characterized by reduced vision of the eye due to the presence of a sensory impediment during visual development…
- Trial name
- NCT00312390
- Testing
- Flicker, Retinal Vessel Diameter, Retinal Blood Flow
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Brain Insulin Sensitivity, Brain Vascular Function
High-Dairy Food Patterns and Gut-Brain Axis
Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT07355309
- Testing
- High-dairy food pattern, Low-dairy food pattern
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Parkinson's Disease (PD), Anxiety
Blood Flow Restriction Aerobic Exercise for Balance and Anxiety in Parkinson's Disease
Reducing balance problems and anxiety severity are the top two research uncertainties for people with Parkinson's disease (PD). Besides having a mutually aggravating relationship between postural impairment and anxiety severity…
- Conditions
- Parkinson's Disease (PD), Anxiety, Postural Balance
- Trial name
- NCT07831980
- Testing
- Aerobic Exercise with Blood Flow Restriction, Aerobic Exercise without Blood Flow Restriction
- Volunteers
- 54 people
- Sponsor
- National Cheng-Kung University Hospital
Blood Pressure, Subarachnoid Hemorrhage
Blood Pressure Treatment in ICU Patients with Subarachniodal Haemorrhage.
An MRI study to examine the relationship between blood pressure and cerebral blood flow in patients with subarachnoidal hemorrhage and suspect or verified vasospasm.
- Conditions
- Blood Pressure, Subarachnoid Hemorrhage, Aneurysm Cerebral
- Trial name
- BFBP (NCT06033378)
- Testing
- Blood pressure elevation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Umeå University
Brain Blood Flow, Neurovascular Control
Cardiovascular and Neurovascular Regulation in GWI
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
- Trial name
- NCT04586049
- Testing
- MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Traumatic Brain Injury (TBI)
Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)
BACKGROUND: The brain is very sensitive to both excessive and insufficient flow of blood. Cerebral blood flow (CBF) is normally auto-regulated by the blood vessels in the brain, but this protective mechanism is often disturbed…
- Trial name
- REG01 (NCT01605838)
- Where
- United States
- Sponsor
- Advanced Brain Monitoring, Inc.
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Gastrointestinal Neoplasms
Cerebral Blood Flow During Propofol Anaesthesia
General anaesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered during anaesthesia to maintain blood pressure.
- Trial name
- NCT02951273
- Testing
- Study of cerebral blood flow
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP)
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This Phase IIb study aims to evaluate the safety and efficacy of BV100 in combination with low dose polymyxin B plus ceftazidime/avibactam or cefiderocol in patients with suspected or confirmed CRABC infections.
- Conditions
- Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial
- Trial name
- RIV- CARE (NCT07431307)
- Testing
- BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT)
- Volunteers
- 120 people
- Sponsor
- BioVersys AG
Postoperative Delirium After On-pump Cardiac Surgery
Preoperative Transcranial Doppler as a Predictor for Delirium Following On-pump Cardiac Surgery
Postoperative delirium is an important problem in patients undergoing major cardiac surgery and associated with more complicated hospital course, increased hospital length of stay and total postoperative cost.
- Trial name
- NCT02478736
- Testing
- No actual intervention
- Where
- South Korea
- Volunteers
- 175 people
- Sponsor
- Yonsei University
Acute Kidney Injury, Children
Renal Oxygen Saturation and Its Association With Acute Renal Injury
Peri-operative renal dysfunction is a major mortality and morbidity cause following cardiac and major vascular surgery. Although several intra-operative strategies are proposed for better outcomes, no effective and fast resulting…
- Conditions
- Acute Kidney Injury, Children, Cardiac Surgery
- Trial name
- NCT03608956
- Where
- Turkey (Türkiye)
- Sponsor
- Marmara University
Ischemic Stroke
The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Stroke
This randomized controlled trial investigates the effect of a single dose of glucagon-like peptide-1 (GLP-1) receptor agonist in the subacute phase of stroke in humans.
- Trial name
- EGRABIS1 (NCT02829502)
- Testing
- Byetta, Normosaline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Christina Kruuse
Traumatic Brain Injury
Effects of Early Skull Repair With Titanium Mesh on Cerebral Blood Flow and Neurological Recovery
To evaluate the feasibility of CT perfusion technique to monitor the changes of blood perfusion in the brain tissue before and after skull repair using titanium mesh.
- Trial name
- NCT03222297
- Testing
- early skull repair, late-stage skull repair
- Volunteers
- 86 people
- Sponsor
- Taihe Hospital