Clinical trials: Cerebral Blood Flows
Parkinson Disease, Orthostatic Hypotension
Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Abnormalities in the regulation of cardiovascular system due to autonomic nervous system (ANS) dysfunction may lead to a sudden decline in blood pressure (BP) upon standing, sitting or performing activities/exercises in patients…
- Trial name
- NCT03343574
- Testing
- Abdominal Strengthening Exercise
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Faizan Ahmed
Sickle Cell Disease
Measurement of Cerebral Blood Flow Using Transcranial Doppler Ultrasound in Children With Sickle Cell Disease
Sickle cell disease (SCD) affects haemoglobin - the molecule in blood cells which carries oxygen. It causes red blood cells to become abnormal crescent (or sickle)- shaped.
- Trial name
- NCT02090881
- Testing
- Ultrasound scan
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College Healthcare NHS Trust
Microcirculation, Coronary Artery Disease
The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
Ischaemic heart disease (IHD) and degenerative brain disease are two major sources of death and disability affecting all countries.
- Conditions
- Microcirculation, Coronary Artery Disease, Cerebrovascular Circulation
- Trial name
- CCMD (NCT06368635)
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Weijing Wang
Astrocytoma, Glioblastoma
Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor
Glioblastomas, the most frequent malignant brain tumor in adults, are widespread in the brain, despite their discrete appearance on computed tomography (CT) or magnetic resonance imaging (MRI).
- Conditions
- Astrocytoma, Glioblastoma, Glioma
- Trial name
- NCT00001148
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injury
A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5.
- Trial name
- NCT03023163
- Testing
- Longitudinal
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Healthy Amateur Divers
Effects of Voluntary Neck Extension on Cerebral Blood Flow, in Breath-hold Divers Ending an Apnoea of Two Minutes or More.
The aim of this study is to demonstrate the effect of the voluntary neck extension in the occurrence of an increase in the pulsatility index of the right internal carotid artery in the amateur diver, realizing an apnea of two…
- Trial name
- APNECK (NCT03210857)
- Testing
- apnea performing
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Dilated Cardiomyopathy, Thrombosis Cardiac
Intraventricular Stasis In Cardiovascular Disease
This study is designed to quantify the ventricular stasis in patients with different forms of cardiomyopathy and at risk of stroke (ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy) by post-processing…
- Conditions
- Dilated Cardiomyopathy, Thrombosis Cardiac, Stroke, Hypertrophic Cardiomyopathy
- Trial name
- ISBIFLOW (NCT04649034)
- Testing
- Doppler echocardiogram exam, Cardiac magnetic resonance, Brain magnetic resonance
- Where
- 3 sites in Spain
- Volunteers
- 258 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Post-Dural Puncture Headache, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Predictive Value of ONSD and NIRS for PDPH
Currently, there is no reliable and effective method available in clinical practice to predict the development of PDPH. Early prediction and prevention of PDPH would reduce the incidence of postoperative complications, thereby…
- Trial name
- NCT07729449
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ordu University
Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy, indicated in case of severe, possibly reversible pulmonary failure, refractory to conventional therapies.
- Trial name
- NOTICE (NCT05303363)
- Testing
- VV-ECMO
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cerebral Blood Flow
Cerebral Blood Flow Velocity Changes During Laparoscopic Surgery
Little is known about how implementation of pneumoperitoneum contributes to cerebral blood flow in pediatrics. We investigated this question in patients undergoing laparoscopic surgery, hypothesizing that cardiorespiratory…
- Trial name
- NCT04291326
- Testing
- Transfontanelle ultrasound
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Diabetes, Obesity
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity.
- Trial name
- NCT06791837
- Testing
- EXERCISE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Ischemic Stroke, Vertebral Artery Ischemia
Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions
Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes.
- Conditions
- Ischemic Stroke, Vertebral Artery Ischemia, Arterial Occlusive Diseases, Vertebrobasilar Insufficiency
- Trial name
- BRAVO (NCT05503212)
- Testing
- Conservative treatment (CT), Intravenous thrombolysis (IVT), Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)
- Where
- Switzerland
- Volunteers
- 682 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Stroke, Ischemic, Ambulation Disorder, Neurologic
Blood Flow Restricted High-Intensity Treadmill Training on Independently Ambulating Chronic Ischemic CVA Survivors
Individuals surviving Chronic Ischemic Stroke have lingering walking deficits long after their infarct. The main goal of this study is to compare two high intensity treadmill walking programs to see which improves walking more.
- Conditions
- Stroke, Ischemic, Ambulation Disorder, Neurologic, Chronic Stroke
- Trial name
- NCT06214494
- Testing
- Blood Flow Restricted High Intensity Treadmill Training, HITT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MedStar National Rehabilitation Network
Acute Cerebrovascular Accident, Thrombectomy
Investigation of Brain Blood Flow Changes in Acute Ischemic Stroke Patients After Successful Endovascular Thrombectomy
Introduction: Endovascular thrombectomy (EVT) is an effective treatment strategy to mitigate the ischemic tissue damage caused by the acute cerebral large-vessel occlusion.
- Conditions
- Acute Cerebrovascular Accident, Thrombectomy, Cerebral Revascularization, No Reflow Phenomenon
- Trial name
- RESTORE-AIS (NCT07534319)
- Testing
- No planned intervention
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Cerebral Hemorrhage, Subarachnoid Hemorrhage
Brain PERfusion Evaluation by Contrast-Enhanced UltraSound
The objective of the study is to assess brain tissue perfusion by contrast-enhanced ultrasound perfusion imaging (PerCEUS) in acute brain injuries.
- Conditions
- Cerebral Hemorrhage, Subarachnoid Hemorrhage, Ischemic Stroke, Cerebrovascular Circulation
- Trial name
- PerCEUS (NCT05893407)
- Testing
- Measuring contrast-enhanced ultrasound perfusion with phase inversion harmonic imaging
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Regional Cerebral Blood Flow, Mild Cognitive Impairment
Effects of Photobiomodulation on Changes in Cognitive Function and rCBF in MCI
This pilot study has two goals. The first is to see if the cognitive improves when VA and CA are stimulated in MCI patients, and the second is to do an explanatory data analysis to see if that improves cognitive in relation to…
- Conditions
- Regional Cerebral Blood Flow, Mild Cognitive Impairment, Cognitive Function
- Trial name
- NCT04721093
- Testing
- Photobiomodulation device
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Pusan National University Yangsan Hospital
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise: Younger Cohort
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT06446622
- Testing
- MRI
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Post-Dural Puncture Headache
Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache
To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement…
- Trial name
- PDPH (NCT06253754)
- Testing
- MRI examination
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Umeå University
Headache
Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients
The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.
- Trial name
- NCT00564408
- Testing
- Carbachol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center
Parkinson Disease, Orthostatic Hypertension
Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD
The goal of clinical trial is to learn about how blood pressure fluctuations affect cognitive performance (thinking abilities) and brain blood flow in persons with Parkinson's disease with and without orthostatic hypotension (low…
- Conditions
- Parkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive Impairment
- Trial name
- NCT06252376
- Testing
- Head-up tilt table
- Sponsor
- University of California, San Diego