Clinical trials: Cerebral Blood Flows
Diabetes
UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation
Cerebral autoregulation (CA) is a complex mechanism that serves the essential and vital purpose of controlling cerebral blood flow and metabolism. A stable and optimal brain blood flow is imperative for normal brain function.
- Trial name
- UTLight (NCT02178787)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Ischemic Stroke, Cerebral Ischemia
Study of the Rate of Progression of Cerebral Ischemia in Afro-Caribbeans
To compare the progression of cerebral ischemia from HF in Afro-Caribbean patients admitted to the CHUG to that of patients from Nantes included in the national ETIS registry.
- Conditions
- Ischemic Stroke, Cerebral Ischemia, Endovascular Treatments
- Trial name
- VESPERALS (NCT07230925)
- Testing
- No Interventions
- Where
- Guadeloupe
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Changes in Blood Flow to the Brain, Changes Depending on the Form of Walking
Influence of Direction of Movement While Walking
The aim of the study is evaluation of cerebral blood flow (based on testing the rate of flow in middle cerebral arteries by transcranial Doppler ultrasound) during different forms of walking training - walk forwards and…
- Trial name
- NCT01254968
- Where
- Poland
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Obesity
Cerebral Blood Flow Changes in People With Obesity After Glucose Consumption
This study evaluates the hypothesis that a meal constituted of only glucose produces differences in the brain blood flow in people with obesity that are not observed in people without obesity.
- Trial name
- NCT02072694
- Testing
- 75 grams of glucose plus water solution, Pure water
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Acute Stroke, Ischemic Stroke, Acute
Rescue Extracranial Vertebral Stenting in Tandem Occlusions
The acute vertebrobasilar occlusion associated with the poor prognosis, particularly tandem occlusion. However, few data on the efficacy of the endovascular therapy was indicated in this occlusion.
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Vertebro Basilar Ischemia
- Trial name
- REVET (NCT06365294)
- Testing
- Rescue extracranial stenting
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Dr. Cuong Tran Chi
Hodgkin Lymphoma, Adult
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St.
- Trial name
- NCT06421987
- Testing
- Near Infrared Spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Anesthesia, Anesthesia; Reaction
Individual Cerebral Hemodynamic Oxygenation Relationships
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two…
- Trial name
- ICHOR (NCT04435834)
- Testing
- Propofol or Sevoflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Matthew Borzage
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
PARKINSON DISEASE (Disorder)
Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor…
- Trial name
- CardioParkinso (NCT07478146)
- Testing
- Aerobic training, Usual Care
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Raphael Mendes Ritti Dias
Amnesia, Dementia
Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders
This study is divided into two parts. The first part of the study will use MRI technology to view the brain structure of patients with neurological disorders and normal volunteers.
- Conditions
- Amnesia, Dementia, Healthy, Nervous System Disease
- Trial name
- NCT00001362
- Where
- United States
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
PET Imaging of DHA Metabolism
This study will examine the use of positron emission tomography (PET) for measuring docosahexaenoic acid (DHA) absorption from the blood into the brain. DHA is a type of fatty acid found in fish and other seafood.
- Trial name
- NCT00074503
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Thrombectomy, Tandem Occlusion
Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion
1. To evaluate whether stent implantation on the ipsilateral extracranial segment, after intracranial thrombectomy successful recanalization compared with balloon angioplasty (eTICI≥2b_50) for acute anterior circulation tandem…
- Conditions
- Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- START (NCT05902000)
- Testing
- Carotid Stenting, Thrombectomy, Dual antiplatelet treatment
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xueli Cai
Cognitive Function, Mood
Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large amount of research indicates EGCG (amongst other…
- Trial name
- NCT00981292
- Testing
- EGCG
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Alzheimer Disease
Blood Biomarkers from Internal Jugular Vein for the Diagnosis of Alzheimer's Disease
The goal of this observational study is to explore the diagnostic performance of blood biomarkers from the internal jugular vein for the diagnosis of Alzheimer's disease (AD) in patients with cognitive symptoms or concerns.
- Trial name
- NCT06754254
- Testing
- blood biomarkers from the internal jugular vein
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Intracranial Pressure, Cerebral Blood Flows
Combined Flow and Pressure Study of Craniospinal Dynamic
Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible.
- Conditions
- Intracranial Pressure, Cerebral Blood Flows, Infusion Test, Phase Contrast MRI
- Trial name
- REVERT (NCT05068128)
- Testing
- Flow MRI, PERFUSION TEST
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Cerebral Arterial Diseases
Modulation of Brain Blood Flow Using Dichoptic Visual and Auditory Stimulation
Modulation of brain blood flow using dichoptic Visual and Auditory stimulation using REVIVIEW system will be evaluated.
- Trial name
- NCT03632564
- Testing
- REVIVIEW dichoptic audio-visual stimulation
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Visior Technologies Ltd.
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital