Clinical trials: Cerebral Blood Flows
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing
Healthy
Positron Emission Tomography (PET) to Study Brain Signaling
This study uses positron emission tomography (PET) to examine brain function and signaling involving phospholipids, and to see how signaling is related to blood flow.
- Trial name
- NCT00044200
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Palsy
Gait Training Program With Blood Flow Restriction in Children With Cerebral Palsy - EMBRIN: Pilot Study
This is a single-center prospective experimental pilot study to assess the feasibility, tolerability and effect of a 10-week gait training program combined with simultaneous blood flow restriction (BFR) on the walking speed of…
- Trial name
- EMBRIN (NCT06533956)
- Testing
- 10-week gait training program combined with simultaneous blood flow restriction (BFR).
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Angers
Extracorporeal Circulation; Complications, Renal Failure
Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury
During open cardiac surgery, cardiopulmonary bypass (CPB) is used to temporarily replace the function of the heart and lungs. Renal ischemia resulting in acute kidney injury is common after cardiac surgery.
- Conditions
- Extracorporeal Circulation; Complications, Renal Failure, Circulation Disorder, Renal Plasma Flow, Effective
- Trial name
- ICAROX2 (NCT04084301)
- Testing
- High CPB flow
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Traumatic Brain Injury
Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury
the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler
- Trial name
- NCT05182619
- Testing
- ultrasound-guided stellate ganglion block
- Volunteers
- 60 people
- Sponsor
- Sohag University
Brain Vascular Function, Cerebral Blood Flow
Effects of Peanut Consumption on Brain Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Brain Insulin Sensitivity, Cognitive Performance
- Trial name
- NCT05724654
- Testing
- Skin roasted peanuts
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acute Stroke, Brain Ischemia
The Capillary Index Score Trial
This study seeks to investigate the capillary index score (CIS) to further improve patient selection of endovascular treatment (EVT) in acute ischemic stroke (AIS).
- Conditions
- Acute Stroke, Brain Ischemia, Ischemic Stroke
- Trial name
- NCT02618031
- Testing
- Endovascular Treatment (EVT)
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Firas Al-Ali
Stroke, Occlusion, Cerebrovascular
Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy
Endovascular thrombectomy (EVT) has become the standard of care for large vessel occlusion in acute ischaemic stroke (AIS). During clot-retrieval, simultaneous balloon inflation within the internal carotid artery offers transient…
- Trial name
- ProFATE (NCT05020795)
- Testing
- Endovascular thrombectomy
- Where
- United Kingdom
- Volunteers
- 134 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Severe Stenosis or Occlusion of Anterior Intracranial Circulation Vessels
The primary purpose of this study is to examine whether remote ischemic treatment can better the 90 - day neurological outcomes in acute ischemic stroke patients having severe stenosis or occlusion of anterior intracranial…
- Trial name
- RICASO (NCT06823128)
- Testing
- RIC, Guideline-based therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Healthy, Magnetic Resonance Imaging
Development of Techniques for Use in MRI With a Magnetic Field of 7 Tesla
This study will develop new techniques for optimizing resolution in magnetic resonance imaging (MRI) with a high magnetic field of 7 Tesla.
- Trial name
- NCT00056914
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
The Correlation Between CITED2 and Collateral Circulation in Acute Ischemic Stroke
Evaluating the collateral circulation of acute ischemic stroke (AIS) mainly depends on the imaging examination. At present, there is no effective and sensitive biomarker for collateral circulation.
- Trial name
- NCT05345366
- Testing
- non-applicable
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhujiang Hospital
PreDiabetes
Study: Diet and Exercise Study to Improve Brain Blood Flow: Blood Flow Improvement Trial
Project Summary Metabolic syndrome (MetS) is associated with the development of diabetes and cardiovascular disease; however it is also linked with cognitive decline and dementia.
- Trial name
- BFIT (NCT03117829)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hypoxic Ischemic Encephalopathy
Targeted Temperature Management After In-Hospital Cardiac Arrest
The purpose of this study is to determine whether targeted temperature management at 36.0˚C(TTM-36) in patients who remain unconscious after resuscitation from in-hospital cardiac arrest(IHCA) will reduce death and disability…
- Trial name
- TTM36-IHCA (NCT02578823)
- Testing
- Arctic Sun®, Arcticgel™, Conventional antipyretic treatment
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Type 2 Diabetes, Insulin Sensitivity/Resistance
Exercise and Intranasal Insulin in Type 2 Diabetes
About 6.5 million adults in the United States who are 65 or older have dementia. While the exact cause of dementia is not known, it may be due to changes in the brain.
- Conditions
- Type 2 Diabetes, Insulin Sensitivity/Resistance, Cognition, Brain Blood Flow
- Trial name
- NCT07675499
- Testing
- Intranasal Insulin, High Intensity Exercise
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Healthy Lifestyle, Physical Exercise
Lifestyle and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Healthy Lifestyle, Physical Exercise, Healthy Diet, Cerebrovascular Circulation
- Trial name
- NCT04234009
- Testing
- Healthy Lifestyle
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Fat Processing in the Brain
How Fat Influences the Brain
The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.
- Trial name
- NCT01516021
- Testing
- intake of high or low fat yoghurt
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Cerebrovascular Circulation
The Impact of Non-pulsatile Blood Flow on CO2-Reactivity
The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled in this prospective case control study.
- Trial name
- NCT03732651
- Testing
- alteration of PaCO2 level
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Type1diabetes, Hypoglycemia Unawareness
The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia
It is thought that altered brain lactate handling is involved in the development of impaired awareness of hypoglycemia (IAH), i.e. the inability to timely detect hypoglycemia in people with type 1 diabetes (T1DM).
- Trial name
- NCT03730909
- Testing
- Sodium Lactate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intracranial Hypertension, Cerebral Circulatory Failure
Cerebral Compliance Impairment in COVID-19
Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing…
- Trial name
- NCT04429477
- Testing
- Cerebral compliance and hemodynamics monitoring
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo