Clinical trials: Cerebral Blood Flows
Acute Ischemic Stroke, Large Vessel Occlusion
Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as a standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Neutrophil Extracellular Trap Formation
- Trial name
- NCT07552610
- Testing
- Sivelestat sodium, Endovascular Thrombectomy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Premature Birth
Study on the Development of Neonatal Cerebral Blood Flow Based on Ultrafast Ultrasound Doppler Imaging
Recently, with the development of perinatal medicine in China, the establishment of neonatal intensive care unit (NICU) and the improvement of respiratory support technology, the survival rate of preterm and term neonates has…
- Trial name
- NCT05761548
- Testing
- ultrafast ultrasound power Doppler imaging
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Hemodynamics of Cranial Arteries, Headache
The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers
To investigate the hemodynamic effects of CGRP after glibenclamide administration.
- Conditions
- Hemodynamics of Cranial Arteries, Headache, Cerebral Blood Flow
- Trial name
- NCT04231617
- Testing
- glibenclamide, CGRP infusion
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Brain Blood Flow, Neurovascular Control
Cardiovascular and Neurovascular Regulation in GWI
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
- Trial name
- NCT04586049
- Testing
- MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Acute Ischemic Stroke
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2
This study is a randomized, double-blind, placebo-controlled clinical trial. Investigators aim to assess the efficacy and safety of interleukin-6 receptor inhibitor combined with endovascular treatment in patients with acute…
- Trial name
- IRIS-2 (NCT07263776)
- Testing
- Tocilizumab
- Where
- 54 sites in China
- Volunteers
- 692 people
- Sponsor
- Capital Medical University
Cerebrovascular Accident
Blood Pressure Lowering in Acute Stroke Trial (BLAST)
Patients who are suffering from a stroke often present to the hospital with elevated blood pressure. Elevated blood pressure in the setting of stroke increases the risk of brain swelling or bleeding into the brain.
- Trial name
- NCT00627991
- Testing
- Valsartan
- Where
- United States
- Sponsor
- Stanford University
Heart Arrest, Out-Of-Hospital, Biomarkers
Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) is one of the leading cause of death in the world. In Slovenia approximately 25% of resuscitated patients survives to discharge from hospitals, usually with poorer functional status.
- Conditions
- Heart Arrest, Out-Of-Hospital, Biomarkers, Oxidative Stress, Neurological Injury
- Trial name
- NCT04563000
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Hypotension
Sequential Compression Device (SCD) for Stabilizing Hemodynamics in the Beach Chair Position
This study is a 3-legged randomized study examining whether during shoulder surgery performed in the beach chair position active compressions of the lower leg with a sequential compression device (SCD) have a superior effect on…
- Trial name
- NCT01680393
- Testing
- Sequential compression device, TED stockings
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Irritable Colon, Irritable Bowel Syndrome (IBS)
Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers
This is a three-period crossover study to compare GW876008 and placebo to see if GW876008 will normalise blood flow responses after different emotional stimuli.
- Trial name
- NCT00376896
- Testing
- GW876008 200mcg, GW876008 20mcg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sepsis, Delirium
Cerebrovascular Autoregulation During Sepsis
The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.
- Trial name
- NCT01029080
- Testing
- no interventions
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johannes Gutenberg University Mainz
Cerebral Arterial Diseases
Hemodynamic and Functional Characteristics of the Cerebral Circulation in Obesity
This prospective study is intended to explore differences in the cerebral hemodynamics and vascular functional characteristics between obese and normo-constituted patients; as well as the changes in the hemodynamic and functional…
- Trial name
- HemOB (NCT06067113)
- Testing
- Supraaortic and transcranial duplex
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Cerebral Blood Flow
Cerebral Blood Flow Using Transfontanelle Ultrasound
We planned to evaluate cerebral blood flow and its association with age, blood pressure, and end tidal carbon dioxide in small pediatric using transfontanelle ultrasound during general anesthesia.
- Trial name
- NCT04070339
- Testing
- transfontanelle ultrasound
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Diabetes, Obesity
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity.
- Trial name
- NCT06791837
- Testing
- EXERCISE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes
UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation
Cerebral autoregulation (CA) is a complex mechanism that serves the essential and vital purpose of controlling cerebral blood flow and metabolism. A stable and optimal brain blood flow is imperative for normal brain function.
- Trial name
- UTLight (NCT02178787)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Carotid Artery Diseases
Investigation of Contact Based Method for Diagnosis of Cardiovascular Disease
In the proposed method of sensing the vital health sign related to cardiovascular diseases, thermal heat transfer performance of the skin will be evaluated using a non-contact based Infra-Red temperature sensor.
- Trial name
- INDICES (NCT03217214)
- Testing
- Thermography
- Where
- Singapore
- Volunteers
- 67 people
- Sponsor
- National Heart Centre Singapore
Obesity
MRI Based Study to Assess Brain-gut Axis in Obesity
The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood.
- Trial name
- BGImaging (NCT05437653)
- Testing
- Nutritional Drink A, Nutritional Drink B
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Acute Ischemic Stroke
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel…
- Trial name
- SUPERSTAR (NCT07555977)
- Testing
- Super Large Bore Catheter, Stent Retriever Thrombectomy
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Brain Insulin-sensitivity, Brain Vascular Function
Effects of Wild Blueberry Consumption on Brain Function in Elderly
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is associated with cognitive decline.
- Conditions
- Brain Insulin-sensitivity, Brain Vascular Function, Cerebral Blood Flow
- Trial name
- NCT07177781
- Testing
- Wild blueberry powder
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Stroke (CVA) or Transient Ischemic Attack
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
A human subjects research study, the primary purpose of which is to assess the EFFECTS OF SEMAGLUTIDE ON INTRACRANIAL BLOOD FLOW AND BLOOD-BRAIN BARRIER PERMEABILITY IN TYPE-2 DIABETES (T2D) through testing of the intervention on…
- Trial name
- NCT05780905
- Testing
- Semaglutide Auto-Injector
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington