Clinical trials: Cerebral Blood Flows
Orthostatic Intolerance
Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury.
- Trial name
- NCT01498809
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Cerebral Palsy Spastic Hemiplegic
Effect of Blood Flow Restriction Training Exercises on Hand Grip Strength in Hemiparetic Cerebral Palsied Children
The study aims to investigate the effect of blood flow restriction (BFR) training exercises on the hand grip strength of children with hemiparetic cerebral palsy.
- Trial name
- NCT07347795
- Testing
- Blood Flow Restriction Training Exercises group, control group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Magnetic Resonance Imaging, Cerebrovascular Circulation
Brain Blood Vessel Responses to Changes in Blood Flow
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
- Trial name
- NCT06629077
- Testing
- MRI, Prazosin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Type 2 Diabetes, Insulin Sensitivity/Resistance
Exercise and Intranasal Insulin in Type 2 Diabetes
About 6.5 million adults in the United States who are 65 or older have dementia. While the exact cause of dementia is not known, it may be due to changes in the brain.
- Conditions
- Type 2 Diabetes, Insulin Sensitivity/Resistance, Cognition, Brain Blood Flow
- Trial name
- NCT07675499
- Testing
- Intranasal Insulin, High Intensity Exercise
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Ischemic Stroke
Acetyl-leucine in Post-stroke Ataxia
Along with the current clinical trial, the efficacy and safety of 4 gram of acetyl-leucine daily for three months in patients with post-stroke ataxia following posterior-circulation ischaemic stroke assessed through BBS, SARA…
- Trial name
- NCT07275749
- Testing
- Acetyl-Leucine, Clopidogrel 75 Mg Oral Tablet, aspirin 100mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kafrelsheikh University
Parkinson's Disease
Parkinson's Disease Evaluated by PET and the Effect of Memantine
Purpose of study: To investigate whether the NMDA antagonist Memantine has a substantial effect of brain metabolism in patients with Parkinson's disease (PD), using Positron Emission Tomography (PET).
- Trial name
- NCT00375778
- Testing
- memantine (drug)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Hypoglycemia, Cerebral Blood Flow
External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery…
- Trial name
- NCT07082478
- Testing
- in-ear device measuring blood flow
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Subjective Cognitive Decline, Age-Related Cognitive Decline
Lifestyle, Exercise and Diet: The LEAD Study
This study will explore the impact of an exercise and nutrition (EX+NUTR) , relative to exercise alone (EX) intervention, on brain structure and function as well as blood biomarkers in older adults with subjective cognitive…
- Trial name
- LEAD (NCT03056508)
- Testing
- Exercise plus nutrition, Exercise
- Where
- 4 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Rotman Research Institute at Baycrest
Amnesia, Dementia
Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders
This study is divided into two parts. The first part of the study will use MRI technology to view the brain structure of patients with neurological disorders and normal volunteers.
- Conditions
- Amnesia, Dementia, Healthy, Nervous System Disease
- Trial name
- NCT00001362
- Where
- United States
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events
Acute ischemic stroke caused by large vessel occlusion (LVO) is a major cause of disability, and mechanical thrombectomy (MT) has become the standard treatment for eligible patients.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Anterior Circulation Brain Infarction
- Trial name
- TRACE- BRIDGE (NCT07748039)
- Testing
- rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone)
- Where
- 5 sites in China
- Volunteers
- 1,440 people
- Sponsor
- Yongjun Wang
Headache
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of carbachol.
- Trial name
- NCT00357864
- Testing
- carbachol
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Healthy, Abnormal Vascular Flow
Racemic Ketamine Versus S-ketamine With Arterial Spin Labeling (ASL)-MRI in Healthy Volunteers
Racemic ketamine and S-ketamine are used in clinical practice today. Little is known of their difference in effect on cerebral blood flow, volume and metabolism.
- Trial name
- NCT01506921
- Testing
- Racemic ketamine, S-ketamine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Lund University
Stroke Ischemic
Effect of Repetitive Transcranial Magnetic Stimulation on Neurological Recovery in Patients With Ischaemic Stroke
The goal of this clinical trial is to learn if transcranial magnetic stimulation(rTMS) can improve neurological rehabilitation in patients with acute ischemic stroke.
- Trial name
- NCT06415734
- Testing
- rTMS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cerebral Infarct, Neurological Morbidity
Evaluation of Cerebral Parenchymal Changes in Patients Undergoing Proximal Aortic Surgery With Deep Hypothermic Circulatory Arrest Using Diffusion MRI
Deep hypothermic circulatory arrest (DHCA) (18 degree) without cerebral perfusion is a safe technique. Resarchers use this technique in patients with proximal aortic pathologies.
- Conditions
- Cerebral Infarct, Neurological Morbidity, Neurological Complication
- Trial name
- NON (NCT04755439)
- Testing
- DHCA
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Epilepsy, Depression
Measuring Blood Flow in the Brain After Epileptic Activity
In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT).
- Conditions
- Epilepsy, Depression, Postictal Delirium, Electroconvulsive Therapy
- Trial name
- SYNAPSE (NCT04028596)
- Testing
- Paracetamol, Nimotop
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
Major Depression, Anxiety Disorder
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression
A pilot study to evaluate the ability of photobiomodulation to alter cerebral blood flow in the frontal poles and to affect the emotional status of patients with major depression.
- Conditions
- Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
- Trial name
- NCT00961454
- Testing
- Photobiomodulation with a super-luminous light emitting diode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Blood Pressure and Cerebral Blood Flow After Cardiac Arrest
Comatose patients that are admitted to an intensive care unit after out-of-hospital cardiac arrest (OCHA) have a high mortality, particularly due to hypoxic-ischemic neurologic injury.
- Trial name
- NCT05434910
- Testing
- Changes in mean arterial pressure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Niels Damkjær Olesen
Delirium - Postoperative, BDNF
The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury…
- Conditions
- Delirium - Postoperative, BDNF, CABG
- Trial name
- NCT06967779
- Where
- Poland
- Volunteers
- 107 people
- Sponsor
- Pomeranian Medical University Szczecin
Vertebrobasilar Insufficiency, Ischemic Attack, Transient
Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS)
Patients with blockage of the blood vessels that supply blood to the back of the brain, known as vertebrobasilar disease (VBD), are at risk of having a stroke or temporary symptoms of a stroke known as transient ischemic attack…
- Conditions
- Vertebrobasilar Insufficiency, Ischemic Attack, Transient, Cerebrovascular Disorder, Brain Ischemia
- Trial name
- VERiTAS (NCT00590980)
- Where
- 6 sites in United States, Canada
- Volunteers
- 82 people
- Sponsor
- University of Illinois Chicago