Clinical trials: Cerebral Circulatory Disorder
Stroke, Cerebrovascular Disorders
Long-term Telerehabilitation for Patients With Stroke
The aim of the current protocol is to study 40 patients, each for 12 weeks, to address hypotheses related to the ability of a telerehabilitation system to (a) improve motor status and disability, (b) collect various forms of…
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT03460587
- Testing
- Telerehabilitation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, Irvine
Stroke, Upper Extremity Paresis
Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study
The aim of this comparative and reliability study is to highlight a deficit in the use of vibrotactile sensory feedback (haptic effect) in the planning and execution of fine manual dexterity movements after stroke.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS (NCT06344221)
- Testing
- Dextrain Manipulandum and haptic feedback device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Severe Stroke or Similar Neurological Muscle Weakness
Mobility Training Using Exoskeletons for Functional Recovery After Stroke
The purpose of this study is to assess the safety and effectiveness of the Ekso robotic exoskeleton in persons affected by a severe stroke.
- Trial name
- NCT02128152
- Testing
- Ekso exoskeleton
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Brain Computer Interface (BCI) Based Robotic Rehabilitation for Stroke
The trial aims to test a novel rehabilitation device for subacute stroke hemiplegic upper limbs based on state-of-the-art non invasive Brain-Computer Interface (BCI) robotic rehabilitation in a clinical setting.
- Trial name
- NCT00955838
- Testing
- Rehabilitation technique
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National Neuroscience Institute
Traumatic Shock, Hemorrhagic Shock
Prehospital Norepinephrine and Early Mortality in Traumatic Shock
The effect of early, prehospital norepinephrine use in patients with traumatic shock on mortality is unknown. Recent existing observational evidence from single system data (US, France, Japan) are conflicting.
- Conditions
- Traumatic Shock, Hemorrhagic Shock, Traumatic Brain Injury, Hypotension and Shock
- Trial name
- NCT04497155
- Testing
- Norepinephrine
- Volunteers
- 2,164 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cardiovascular Diseases, Heart Diseases
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
Coronary heart disease (CHD) is a serious health concern that affects millions of people in the United States. It is usually caused by atherosclerosis-a condition that occurs when fatty material and plaque build up on the walls…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Atherosclerosis
- Trial name
- HDL Proteomics (NCT00880178)
- Testing
- Simvastatin and Extended-Release niacin, Simvastatin
- Where
- 29 sites in United States, Canada
- Volunteers
- 324 people
- Sponsor
- University of Washington
Acute Stroke
Cerebral Blood Flow-guided Early Rehabilitation Intervention After Stroke: a Pilot Randomized Trial (STAND-OP)
The primary goal of most acute stroke interventions is to restore cerebral blood flow (CBF) in the affected region and prevent hypoperfusion during early clinical course.
- Trial name
- STAND-OP (NCT04848285)
- Testing
- Early Mobilization, Standard care
- Where
- Spain
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stroke, Cognitive Training
Comparing Personalized and Adaptive Cognitive Training Methods Following Stroke
This study aims to assess the efficacy of two cognitive training programs - one tablet-based (NeuroAIreh@b) and one in paper-and-pencil format (Task Generator) - in improving cognitive and noncognitive outcomes among…
- Trial name
- NCT05929287
- Testing
- Tablet-based CT, Paper-and-pencil CT group
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Universidade da Madeira
Stroke, Ischemic, Stroke Patients
The Effect of Endurance Training on Motor and Cognitive Functions and Concentration of Biomarkers in Post-stroke Patients
The aim of this randomised experimental study is to test the effect of different intensities of aerobic exercise on neurotrophin concentration and functional and cognitive functions in post-stroke patients undertaking a single…
- Trial name
- NCT06824116
- Testing
- Exercise
- Where
- Poland
- Volunteers
- 44 people
- Sponsor
- Poznan University of Physical Education
Facial Palsy, Stroke
Effect of Neuromuscular Electrical Stimulation on Unilateral Central Facial Palsy
Background Central facial palsy (CFP) is a common condition in stroke, with an estimated prevalence of 45%. CFP can lead to facial asymmetry, problems with mouth closure and food processing, bite marks on the cheek, social…
- Trial name
- NCT07325604
- Testing
- Neuromuscular electrical stimulation (NMES), Usual Care
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- University of Aarhus
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Dementia, Stroke
MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II
A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on cognitive change and several…
- Conditions
- Dementia, Stroke, Cognitive Change, Cerebrovascular; Disorder, Thrombotic
- Trial name
- NCT06331247
- Testing
- General dietary advice, Localized MIND diet intervention, Routine medical care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Ischemic Stroke
Discovering Patterns in the Gut Microbiota Associated With the Risk of Stroke and the Outcome After a Stroke and Integration of These Data With Genomic Information to Find New Drug Targets and New Treatments to Improve Neurological Evolution and Functional Status of Stroke Patients.
The composition of the intestinal microbiota is associated with the risk of stroke and with post-stroke neurological evolution. At the same time, the genetics and epigenetics of each patient are associated with the composition of…
- Trial name
- MAESTRO (NCT04795687)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Coronary Heart Disease, Stroke
Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
- Conditions
- Coronary Heart Disease, Stroke, Renal Failure
- Trial name
- SDIS (NCT02138006)
- Testing
- Intensive insulin treatment, Standard insulin treatment
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Karolinska Institutet
Cancer, Stroke
Anticoagulation in Cancer Related Stroke
Purpose: Cancer associated intravascular coagulopathy is the primary mechanism of cancer-related stroke, particularly in those without conventional stroke etiologies.
- Trial name
- OASIS-CANCER (NCT02743052)
- Testing
- Anticoagulation treatment.
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Hypoxic Ischemic Encephalopathy of Newborn, Feeding Patterns
Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy
Therapeutic hypothermia (TH) is accepted worldwide as a standard of care for infants born at or beyond 36 weeks gestational age with moderate-to-severe hypoxic ischaemic encephalopathy (HIE).
- Trial name
- NCT06447155
- Testing
- Bolus feeding, Continuous feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Training and Research Hospital
Stroke
Optimizing Current and Electrode Montage for Transcranial Direct Current Stimulation in Stroke Patients
The purpose of this study is to determine the optimal transcranial direct current stimulation (tDCS) amplitude and electrode montage that is both safe and efficacious
- Trial name
- COBRE_JIpro3 (NCT02763826)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Medical University of South Carolina
Stroke
ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion
The purpose of TRIMIS is to study how a medical procedure by the name of endovascular therapy compares to medical treatment alone in patients with mild stroke and a blood vessel occlusion in the brain
- Trial name
- TRIMIS (NCT06778226)
- Where
- 3 sites in United States
- Volunteers
- 4,827 people
- Sponsor
- University of Miami
Stroke
Stroke Prevention and Treatment System in Shanghai: a Network of Public Healthcare of Stroke
The Shanghai Stroke Service System（4S） has been established as the network of stroke care in greater Shanghai metropolitan area.
- Trial name
- SSSS (NCT02735226)
- Testing
- stroke network and policy intervention
- Where
- 11 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Shanghai Stroke Service System
Stroke, Stroke Ischemic
duoABLE for People With Stroke and Their Caregivers
The goal of this intervention study is to test whether a behavioral program that involves people with stroke and their caregivers is acceptable, safe, and can promote physically active lifestyles using enjoyable activities.
- Conditions
- Stroke, Stroke Ischemic, Stroke Hemorrhagic, Stroke Sequelae
- Trial name
- NCT05964400
- Testing
- duoABLE
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Minnesota
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