Clinical trials: Cerebral Circulatory Failure
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Ataxia Telangiectasia, Growth Failure
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT)
This study will evaluate the status of the growth hormone/ insulin-like growth factor-1 (GH/IGF-1) axis in relation to growth failure, body weight and composition and neuroprotection in children with Ataxia telangiectasia (AT).
- Trial name
- GHAT (NCT01052623)
- Testing
- Somatropin, Clonidine, L-Arginin-Hydrochloride, Estradiol valerate
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Acute Kidney Injury, Renal Insufficiency, Chronic
Acute Kidney Injury Genomics and Biomarkers in TAVR Study
In the last decade, transcatheter aortic valve replacement (TAVR) has become an increasingly utilized alternative procedure for replacing a stenotic aortic valve.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Heart Failure, Myocardial Infarction
- Trial name
- NCT02791880
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Hemorrhagic Shock, Traumatic Brain Injury
Hypertonic Modulation of Inflammation Following Injury
This project seeks to determine the effect of prehospital resuscitation with hypertonic saline vs. conventional crystalloids on the inflammatory response after injury.
- Trial name
- NCT00750997
- Testing
- hypertonic saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 119 people
- Sponsor
- University of Washington
Septic Shock
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the…
- Trial name
- NCT02706379
- Testing
- Local cerebral oxygen saturation
- Volunteers
- 26 people
- Sponsor
- Southeast University, China
Heart Failure
A Study to Evaluate the Effects of EECP in Patients With Heart Failure
The aims of this proposal are to investigate whether external enhanced counterpulsation (EECP) can facilitate heart failure (HF) patient weaning from intravenous infusion of positive inotropic agent, and thus decrease the length…
- Trial name
- NCT03857022
- Testing
- Enhanced External Counterpulsa
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease
Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus
The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve cognitive function by having less effect on brain blood flow.
- Trial name
- NCT03413722
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage
The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Sepsis Syndrome, Sepsis
- Trial name
- NCT05246969
- Testing
- Sepsis detection
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Goethe University
Chronic Obstructive Pulmonary Disease, Heart Failure
Well Being and Rehabilitation in Chronically Ill Patients: Structured Patient Education and Physical Exercise
This study addresses self management and maintenance of health through evaluation of a program of patient education in combination with physical training and with a structured follow-up.
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Stroke
- Trial name
- NCT00989456
- Testing
- Self management education programme, exercise only
- Where
- 5 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Ischemic Heart Disease, Cardiomyopathy
Growth Hormone Deficiency in Chronic Heart Failure: an Observational Study
Aim of this study is to define the possible detrimental effect of a lack of growth hormone, on the well-being and life expectation of patients affected by heart failure.
- Conditions
- Ischemic Heart Disease, Cardiomyopathy, Heart Failure, Growth Hormone Deficiency
- Trial name
- NCT00511927
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Federico II University
Heart Failure, Coronary Artery Disease
The Usefulness of Growth Differentiation Factor 15 (GDF-15) for Risk Stratification in Cardiac Surgery
Growth determination factor 15 (GDF-15) and high sensitive troponin-t (hsTnT) are emerging humoral markers for risk stratification in clinically stable heart failure patients and in patients with stable coronary artery disease.
- Trial name
- NCT01166360
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Luebeck
Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation
Post-operative atrial fibrillation (POAF) is a frequent complication of surgical aortic valve replacement, affecting 38 to 63% of patients, and increasing risks of stroke, heart failure, and long-term mortality.
- Conditions
- Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA), Heart Failure, Myocardial Infarction (MI)
- Trial name
- VAGASTIMA-PILT (NCT07891390)
- Testing
- tVNS session on the left earlobe
- Where
- 3 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure, Chronic Obstructive Pulmonary Disease
Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding…
- Trial name
- NCT04350541
- Testing
- High-intensity interval training, Continuous aerobic training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
Sepsis, Heart Failure
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels
Brain natriuretic peptide (BNP) is involved in the regulation of blood pressure and fluid volume. It is used for the early diagnosis of heart failure (HF) in patients presenting to the emergency room with dyspnea.
- Trial name
- NCT01382394
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Heart Failure
Brain Volume and Cardiac Function in Heart Failure
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population.
- Trial name
- NCT06623344
- Testing
- Magnetic Resonance Imaging with or without Contrast
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Myocardial Infarction
Improving How Older Adults at Risk for Cardiovascular Outcomes Are Selected for Care Coordination
This pragmatic clinical trial embedded in an accountable care organization will determine the comparative effectiveness of two approaches for assigning care coordinators to older adults at risk for cardiovascular outcomes.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Atrial Fibrillation, Diabetes Mellitus
- Trial name
- NCT05820295
- Testing
- Care coordination delivered based on perceived need, Care coordination delivered based on usual care (e.g. discharge from hospital)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Acute Coronary Syndromes
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method）
The aim of the study is to evaluate diagnostic performance of N-terminal Brain natriuretic Peptide (NT-proBNP) in acute heart failure among Chinese population.
- Trial name
- NT-proBNP，HF (NCT06691477)
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 1,104 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Atrial Fibrillation (AF), Hypertension
Integrated Approach in Frail Older People with Atrial Fibrillation
The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an…
- Conditions
- Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure
- Trial name
- AFFIRMO (NCT06775028)
- Testing
- iABC platform use
- Where
- 50 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 1,250 people
- Sponsor
- Heart Care Foundation