Clinical trials: Cerebral Concussion
Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder
Transcranial Electrical Stimulation for mTBI
mTBI is a leading cause of sustained physical, cognitive, emotional, and behavioral deficits in OEF/OIF/OND Veterans and the general public.
- Trial name
- TESmTBI (NCT03244475)
- Testing
- TES
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Injury
Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI
Our central hypothesis is that chronic balance deficits after mild traumatic brain injury (mTBI) result from impairments in central sensorimotor integration (CSMI) that may be helped by rehabilitation.
- Trial name
- NCT02748109
- Testing
- Vestibular Rehabilitation + audio biofeedback, Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Traumatic Brain Injury
Longitudinal Study of Traumatic Brain Injury (TBI) in (University of Florida) UF Athletes
To identify the changes in the brain following repeated sports-related concussion in men's football, women's soccer, and women's lacrosse college athletes by reviewing the findings of MRI studies that look at the structure of the…
- Trial name
- GATOR TBI (NCT01890304)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Florida
Concussion, Mild, Concussion, Intermediate
Assessment of Oculomotor, Vestibular and Reaction Time Response Following a Concussive Event
This study is designed to evaluate the use of a collection of tests that measure the eye response, balance, oculomotor and reaction time tests to aid in the diagnosis of mTBI.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NKI-RIF1 (NCT01832714)
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Neurolign
Post Concussion Symptoms
Evaluating Altius Tinted Contact Lenses as an Option Managing for Post-Concussion Visual Syndrome
This pilot study evaluates whether ALTIUS® daily disposable performance-tinted contact lenses provide symptom relief comparable to tinted spectacle lenses in adults with post-concussion visual syndrome.
- Trial name
- NCT07869927
- Testing
- ALTIUS® daily disposable performance-tinted contact lenses
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Southern College of Optometry
Mild Concussion, Brain Concussion
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions
Concussions are defined as a complex pathophysiological process affecting the brain, induced by traumatic biomechanical forces. Currently the standard of care in the treatment for concussions is cognitive and physical rest until…
- Conditions
- Mild Concussion, Brain Concussion, Cerebral Concussion
- Trial name
- NCT01814527
- Testing
- Docosahexaenoic acid
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- East Carolina University
Head Injury, Concussion
Video Review of the Frequency and Assessment of Head Impacts During the FIFA World Cup 2022TM
This is an exploratory observational study. Broadcasted video footage is used to review all head impacts during all 64 matches in the football tournament.
- Conditions
- Head Injury, Concussion, Brain Injuries, Traumatic Brain Injury
- Trial name
- NCT05629169
- Testing
- No intervention applied - observational study only
- Where
- United States
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Federation Internationale de Football Association
Cognitive Deficits, Proprioceptive Disorders
Effects of Multiple Concussions in Retired NHL Players
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
- Trial name
- NHL (NCT02746523)
- Testing
- Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Mild Traumatic Brain Injury
Elucidate the Mechanisms, Development and Effectiveness of Balance Control and Gait Strategy After Mild Traumatic Brain Injury: Develop Innovative Design of Computerized Dual-task Balance Module
The purpose of this study is to innovatively design and develop computerized dual-task balance training modules and home modules, and conduct proactive clinical verification to focus on the effectiveness of balance control and…
- Trial name
- NCT05638659
- Testing
- Computerized dual-task balance and home program, Medical consultation and traditional balance training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Concussion
Vitamin Therapy in Concussion Management: A Randomized Control Trial
The purpose of this study is to assess the efficacy of vitamin therapy in concussion when compared to placebo with respect to multiple endpoints including symptom severity, cognitive performance on computer based…
- Trial name
- NCT02382679
- Testing
- Experimental: Vitamin Mixture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Olfactory Disorder, Smell Disorder
Olfactory Training in Various Populations
To date, there is no validated pharmacotherapy for olfactory disorders. Interestingly, olfactory training - the intentional exposure to odorants for the purposes of retraining the sense of smell - has shown success with as many…
- Conditions
- Olfactory Disorder, Smell Disorder, Traumatic Brain Injury, Concussion, Brain
- Trial name
- NCT06115291
- Testing
- Smell Test
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Traumatic Brain Injury, Trauma
The Effect of Mild Traumatic Brain Injury on Recovery From Injury
Mild traumatic brain injury (TBI) is a common injury that can produce significant functional sequelae and ongoing disabling symptoms.
- Conditions
- Traumatic Brain Injury, Trauma, Head Injury, Brain Concussion
- Trial name
- NCT00295074
- Testing
- neuropsychologic testing
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
Mild Traumatic Brain Injury, Concussion (Diagnosis)
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
Objectives: Approximately one-third of patients with concussion experience persistent symptoms that, in addition to causing serious discomfort, may lead to unemployment and other socioeconomic challenges.
- Trial name
- NCT06644131
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Southern Denmark
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Concussion, Mild
Mindfulness-Based Intervention for Mild Traumatic Brain Injury
Mindfulness is a promising tool which may foster adaptative interpersonal qualities to reduce the risk of persistent post-concussion symptoms.
- Trial name
- MBI-4-mTBI (NCT05105802)
- Testing
- Mindfulness-Based Intervention
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Children's Hospital of Eastern Ontario
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion
Speech Analysis as a Diagnostic Tool for Mild Traumatic Brain Injury
The waveform assessment of an athlete's speech production has a high probability of showing abnormalities after brain injury (concussions) which could be used not only for diagnosis of the concussion, but for recovery of the…
- Trial name
- NCT02069795
- Testing
- Voice recording
- Volunteers
- 50 people
- Sponsor
- Forte Sports Medicine and Orthopedics
Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury
Kids Injury Detection Study Using the i-STAT
KIDS-STAT is a prospective study evaluating whether a rapid blood test measuring the brain injury biomarkers GFAP and UCH-L1 using the i-STAT Alinity system can help identify children with mild traumatic brain injury who do not…
- Conditions
- Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury, Head Trauma
- Trial name
- KIDS-STAT (NCT07835919)
- Testing
- i-STAT TBI Cartridge with the i-STAT Alinity System
- Volunteers
- 700 people
- Sponsor
- Children's Healthcare of Atlanta