Clinical trials: Cerebral Concussion
Mild Traumatic Brain Injury
Auditory Plasticity Training
The investigators are working on a project to help people who have had mild brain injuries hear better. Sometimes, these injuries can make it hard for people to hear clearly, especially in noisy places or when trying to tell…
- Trial name
- NCT06628505
- Testing
- Speech in Noise Training, Spatial Hearing Training Group, Spatial Hearing Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Mild Traumatic Brain Injury
Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Sport Concussion Assessment - Test Stability and Effect of Concussion
Mild traumatic brain injury (mTBI), also known as concussion, occurs commonly in sport. Despite ongoing research, there is no highly sensitive clinical test for cognitive function.
- Trial name
- NCT01535339
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Urinary Tract Infection, Head Injury
Video Discharge Instructions (VDI) as Adjuncts to Written Discharge Instructions in the Emergency Department
Patients seen in the ED with either a laceration, minor head injury, or urinary tract infection will be randomized to one of two groups.
- Conditions
- Urinary Tract Infection, Head Injury, Laceration
- Trial name
- NCT02882256
- Testing
- Video discharge instructions
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- George Washington University
Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF
This hypothesis-generating feasibility study compares mTBI Patients and Controls using advanced MRI Applications.
- Trial name
- TBI-2 (NCT02141360)
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- GE Healthcare
Mild Traumatic Brain Injury
Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation
At least 1 in 5 people who sustain a concussion will have persistent symptoms and difficulties with daily activities. The researchers have identified two unhelpful coping styles following a concussion - avoidance and endurance.
- Trial name
- NCT03972579
- Testing
- Graded exposure therapy, Pacing + mindfulness
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Traumatic Brain Injury, Cognitive Impairment
Brief Telehealth Cognitive Rehabilitation Following Mild TBI
In the United States, more than a million people sustain a mild traumatic brain injury (mTBI) every year. Although many recover fully, emerging literature suggests a high number of individuals report chronic, and functionally…
- Trial name
- On-TRACC (NCT05315453)
- Testing
- Brief Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Washington
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Concussion, Mild
Targeted Multidomain (T-MD) Interventions for Complex Mild Traumatic Brain Injury (mTBI)
Objective: This 3-year multisite RCT will determine the effectiveness of a targeted multidomain intervention (T-MD) (anxiety/mood, cognitive, migraine, ocular, vestibular; and sleep, autonomic) compared to usual care (behavioral…
- Trial name
- T-MD (NCT04549532)
- Testing
- Targeted Multidomain, Behavioral Management
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Concussion, Brain, Sleep Disorder
Addressing Sleep in Adolescents Post-Concussion ("ASAP Study")
Hundreds of thousands of adolescents experience protracted recoveries from concussion, which can affect all aspects of their lives and create family and societal burden.
- Trial name
- ASAP (NCT05736692)
- Testing
- Brief Sleep Intervention
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Traumatic Brain Injury
A Study of Biomarkers of Mild Traumatic BRAIN Injury
Patients with mild traumatic brain injury (mTBI) represent a burden of patients admitted to the emergency department. According to the guidelines, a cerebral CT scan is indicated after mTBI according to the specific conditions.
- Trial name
- BRAINI (NCT04032509)
- Testing
- 2 x 5 mL blood sample
- Where
- 16 sites in France, Spain
- Volunteers
- 1,501 people
- Sponsor
- University Hospital, Grenoble
Post Concussive Syndrome, Chronic
Eye-Tracking Rapid Attention Computation
The purpose of this study is to validate and refine a diagnostic device that can detect attention and memory deficits that result from mild traumatic brain injury (mTBI).
- Trial name
- Eye-TRAC (NCT00743821)
- Where
- United States
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Brain Trauma Foundation
Post-concussion Syndrome, Post-concussive Symptoms
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin
PURPOSE: The long-term goal of this line of research is to develop rational, biologically based evidence for the treatment of post-concussion syndrome (PCS) in children.
- Conditions
- Post-concussion Syndrome, Post-concussive Symptoms, Traumatic Brain Injury, Concussion
- Trial name
- PLAYGAME (NCT01874847)
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Concussion, Sports Injuries in Children
Cervico-vestibular Home Exercise Program Feasibility
The purpose of this pilot study is to: 1. Determine the feasibility of adherence to completing the home cervico-vestibular exercise program following concussion. 2.
- Trial name
- Concussion HEP (NCT07099248)
- Testing
- Cervico-vestibular Home Exercise Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Craniocerebral Trauma, Pediatrics
Study Assessing Evaluation of the Interest of Serum S100B Protein Determination in the Management of Pediatric Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) is a very common reason for presentation to pediatric emergency departments. So as not to overlook the risk of complications, which occur at a rate of 0-7%, measures such as cranial computed…
- Trial name
- PROS100B (NCT02819778)
- Testing
- usual care, S100B
- Where
- 11 sites in France
- Volunteers
- 2,209 people
- Sponsor
- University Hospital, Clermont-Ferrand
Insomnia, Concussion Post Syndrome
Post-Concussion Sleep and Brain-heart Functions
This project is designed as a randomized controlled trial (RCT), with an active control group. Sleep and heart rate will be monitored at home for 1 week before and after the intervention.
- Trial name
- CBT-pI (NCT07636408)
- Testing
- CBT-pI, Sleep Hygiene
- Volunteers
- 70 people
- Sponsor
- University of Ottawa
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Treatment Optimization of Brain-injured Warfighters
Prescribed sub-symptomatic adaptable exercise treatment (SAET) is a potential solution that promotes recovery needs following a TBI.
- Trial name
- (TOBI-SET) (NCT06561100)
- Testing
- Sub-symptomatic Adaptable Exercise Treatment (SAET), Stretching Control Group (SCG)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Post Concussion Syndrome
GyroStim for Post Concussion Syndrome
The goal of this study is to evaluate the efficacy of using sensorimotor multi-axis automated rotational therapy (SMART) to help treat post concussion syndrome (PCS) in adults.
- Trial name
- NCT07527663
- Testing
- Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Neuroscience Group