Clinical trials: Cerebral Disorder
Stroke
Metacognitive-Strategy Training in Sub-Acute Stroke
The long-term goal of this research is to improve activity performance and reduce motor impairment in individuals with stroke. Contemporary stroke rehabilitation focuses on remediation of post-stroke impairments with a false…
- Trial name
- NCT04099511
- Testing
- Usual Care Occupational Therapy-Outpatient, Cognitive Orientation to daily Occupational Performance
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Missouri-Columbia
Alzheimer Disease, Alzheimer Dementia
Multimodal Ocular Imaging in Neurodegeneration
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders.
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Frontotemporal Dementia
- Trial name
- NCT03699644
- Testing
- Spectral-Domain Optical Coherence Tomography (SD-OCT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Prostate Carcinoma
Brain and Pelvic Floor Muscle Activity of Patients Who Had or Are Undergoing Robot-Assisted Radical Prostatectomy
This trial investigates brain and pelvic floor muscle activity in patients undergoing robot-assisted radical prostatectomy. This trial may help identify the brain waves that are associated with muscles involved in giving patients…
- Trial name
- NCT04646434
- Testing
- Electroencephalography, Electromyography, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Roswell Park Cancer Institute
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
This phase I clinical trial is studying the side effects and best dose of giving gamma-secretase inhibitor RO4929097 and cediranib maleate together in treating patients with advanced solid tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT01131234
- Testing
- Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Cerebral Malaria
Randomized Trial of Erythropoietin During Cerebral Malaria
Malaria remains one of the most common life-threatening illnesses in the tropics with a dramatic toll of more than one million deaths each year.
- Trial name
- EPOMAL (NCT00697164)
- Testing
- Erythropoietin
- Where
- Mali
- Volunteers
- 120 people
- Sponsor
- Claude Bernard University
Sleep Deprivation, Aging
The Peripheral Blood Multi-Omics Study on Sleep Loss
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related…
- Conditions
- Sleep Deprivation, Aging, Alzheimer Disease, Healthy Lifestyle
- Trial name
- NCT06492109
- Testing
- Sleep manipulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Tourette's Syndrome
Hypersensitivity in Tourette Syndrome
This study will investigate how the sensitivity to touch and smell in patients with Tourette syndrome (TS) may differ from that of people without TS.
- Trial name
- NCT00368433
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
A Mobile Brain/Body Imaging Platform for the Assessment and Optimization of Post-stroke Overground Robotic Gait Treatments
The study aims to identify neural biomarkers that can be used to monitor the recovery of locomotion and movement of post-stroke patients, both in natural settings and with enriched treatment using robotic device.
- Trial name
- COBI (NCT07510633)
- Testing
- overground wearable robotic device
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Franco Molteni
Bipolar I Disorder, Psychosis
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar…
- Conditions
- Bipolar I Disorder, Psychosis, Schizoaffective Disorder
- Trial name
- NCT06221852
- Testing
- Ketogenic diet, Dietary Guidelines for Americans
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Post-Acute COVID-19, Long COVID
Personalized Computerized Training Program for Cognitive Dysfunction After COVID-19
This before-and-after study aims to evaluate the usefulness and efficacy of a personalized computerized cognitive training (CCT) to improve cognitive function among people with post-acute sequelae of COVID-19 (PASC).
- Trial name
- NCT05571852
- Testing
- CogniFit's CCT Post COVID-19
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Universidad Antonio de Nebrija
Alzheimer Disease, Dementia
SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons With Dementia
The proposed Phase 1 study will involve initial development and evaluation of a new service called Social Activities For Engagement at Home or SAFE at Home (SaH).
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05516147
- Testing
- SAFE at Home
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hopeful Aging
Parkinson Disease
Fox BioNet Project: ECV-003
The goal of this study is to optimize pre-analytical cerebrospinal fluid (CSF) extracellular vesicle isolation protocols for increasing the detection of LRRK2 activity in human CSF
- Trial name
- NCT03775447
- Testing
- Lumbar Puncture
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease
The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease
The purpose of the study is to learn about the impact of exercise on fatigue, anxiety, and depression in Parkinson's disease. It is well established that exercise improves the motor symptoms of Parkinson's disease.
- Trial name
- PDExercise (NCT03833349)
- Testing
- Spinning Class, Yoga Class, Dance Class
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Premier Health
Traumatic Brain Injury, Rehabilitation
Improving Health Outcomes With Resource Facilitation
The purpose of this research is to test a service the investigators of the study believe may increase quality of life after brain injury and reduce the level of disability that might be associated with that injury.
- Conditions
- Traumatic Brain Injury, Rehabilitation, Intervention
- Trial name
- ACL (NCT04462549)
- Testing
- Resource Facilitation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rehabilitation Hospital of Indiana
Caregiver Burden
SilverBills: A Financial and Legal Tech Tool for Caregivers
Financial and legal management for persons with dementia (PwD) is a crucial responsibility of caregivers. This responsibility adds to the stress and strain of caregiving.
- Trial name
- NCT05382949
- Testing
- SilverBills Financial and Legal Tech Tool for Caregivers
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Marci Lobel-Esrig
Brain Injury, Intracranial Hypertension
Evaluation the Intracranial Volume Pressure Response in Increased Intracranial Pressure
The purpose of this study is to discover a mathematic equation to express the intracranial pressure-volume (P-V) curve and a single indicator to reflect the status of the curve.
- Trial name
- NCT01126658
- Testing
- drainage of cerebrospinal fluid (CSF)
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute
Hemodynamic Response and Motor Functions Following Transcranial Direct Current Stimulation in Acute Stroke
The aim of the present study is to evaluate the possible effect of using dual-tDCS applied before conventional physical therapy on motor functions and hemodynamic response
- Trial name
- NCT04051658
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Mahidol University
Moyamoya Disease
Efficacy and Safety of rTMS for Cognitive Rehabilitation in Moyamoya Disease
The purpose of this study is to evaluate the safety and effectiveness of transcranial magnetic stimulation (TMS) therapy in moyamoya patients who received surgical revascularization.
- Trial name
- NCT03543748
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Migraine Headache
A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches
To study the effect of Rozerem, a high affinity MT1 and MT2, low affinity 5-HT2B receptor agonist used for insomnia, as a migraine prophylactic agent.
- Trial name
- NCT00391755
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Charlottesville Neuroscience
Closed Head Injury, Penetrating Head Injury
Comparison of Image Quality Between Ultra-low Dose (ULD) and Standard Dose CT Scans in Detecting Traumatic Brain Injury in the Emergency Room
Head trauma is a frequent reason for consultation in the emergency room. The CT scan is the reference examination allowing rapid management of the patient.
- Trial name
- ULD-CRANE 2 (NCT05210855)
- Testing
- CT scan
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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