Clinical trials: Cerebral Disorder
Pseudotumor Cerebri
Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension
This prospective study will use magnetic resonance imaging of patients with Idiopathic Intracranial Hypertension (IIH), to determine if the common radiological finding of transverse venous sinus stenosis can be reversed with…
- Trial name
- NCT02394067
- Testing
- Radiological Imaging
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Migraine Disorders
Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache
The purpose of this study is to determine which drug makes lower migraine headache
- Trial name
- NCT01791400
- Testing
- metoclopramide, injection,20mg, one time, Sumatriptan, injection, 6 mg, one time
- Where
- Iran
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Stroke, Inflammation
Combinating Fingolimod With Alteplase Bridging With Mechanical Thrombectomy in Acute Ischemic Stroke
Proof-of concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in patients with AIS as a single…
- Trial name
- FAMTAIS (NCT02956200)
- Testing
- Fingolimod
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
Medication Adherence in Individuals With Epilepsy
There is an urgent need to understand the psychological and situational factors that influence medication adherence in individuals with epilepsy.
- Trial name
- NCT01566500
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Columbia University
Mild Cognitive Impairment (MCI)
Impacts of Kebbi Robot Intervention for Older Adults With Mild Dementia
The goal of this clinical trial is to examine the immediate and sustained effects of an intensive Kebbi robot intervention on cognitive functions, heart rate variability (HRV), and psychological changes for older adults with mild…
- Trial name
- NCT06606600
- Testing
- Intensive Kebbi robot interventions
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- National Tainan Junior College of Nursing
Parkinsonism in Diseases Classified Elsewhere
The Efficacy of Online Exergaming-Integrated Physiotherapy for Parkinson's Disease
To validate the efficiency of online exergaming-based physiotherapy. We will enroll patients with Parkinson's disease in postural instability and gait disturbance motor phenotype in the study and divide them into two groups in a…
- Trial name
- NCT06317792
- Testing
- online exergaming-based physiotherapy programs
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Ischemic Stroke
Tongxinluo Capsule in Ischemic Stroke Patients（TISS)
The purpose of this study is to assess the effects in improving life self-care ability of stroke patients after taking Tongxinluo Capsule(within 72 hours after onset) versus Placebos for 90 days.
- Trial name
- NCT01919671
- Testing
- Tongxinluo capsule
- Where
- China
- Volunteers
- 2,007 people
- Sponsor
- yongjun wang
Gaucher Disease
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease to Evaluate Once Daily Versus Twice Daily Dosing (EDGE)
The primary objective of this study was to evaluate the efficacy and safety of once daily (QD) versus twice daily (BID) dosing of eliglustat tartrate (Genz-112638) in participants with Gaucher disease type 1 who had demonstrated…
- Trial name
- NCT01074944
- Testing
- Eliglustat tartrate
- Where
- 46 sites in United States, Australia and 15 more
- Volunteers
- 170 people
- Sponsor
- Genzyme, a Sanofi Company
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Cluster Headache
CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients
It has previously been shown that nitroglycerine induces cluster headache attacks in episodic cluster headache patients (ECH patients) in bouts but not in remission phase.
- Trial name
- NCT02466334
- Testing
- Calcitonin-Gene Related Peptide
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- Danish Headache Center
Brain Tumor
Brain Tumor Surgery and Postoperative Delirium
1. To explore whether the combined administration of dexmedetomidine during and after surgery in patients undergoing brain tumor resection is an effective and safe modality to prevent postoperative delirium and improve sleep…
- Trial name
- NCT06863064
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intracranial Hypertension
Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter
Increased intracranial pressure (IICP) is a common problem in traumatic brain injuries and many medical diseases. Early recognition of IICP can save lives.
- Trial name
- MBLONDE (NCT04211064)
- Testing
- Ultrasonographic measurement of optic nerve sheath diameter, Deep neuromuscular block, Moderate neuromuscular block
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Healthy Volunteers (HV), Parkinson's Disease (PD)
Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease
This is a first-in-human (FIH) study of orally administered VT-5006 (also known as AX-5006) in healthy adult volunteers (HVs) and adult participants with Parkinson's disease (PD).
- Trial name
- NCT07310264
- Testing
- VT-5006
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Vertero Therapeutics
Stroke, Hemiplegia
Usability Testing of Affordable Haptic Robots for Stroke Therapy
Stroke survivors with hemiplegia will be evaluated by rehabilitation professionals and asked to perform a battery of assessments to test the viability and usability of a force-feedback robot that adapts to each individual…
- Trial name
- Theradrive (NCT02772809)
- Testing
- Haptic Robot Therapy with Games
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Aneurysm, Cerebral, Endovascular Procedures
Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm
Perform a randomized comparison study of dual-antiplatelet (aspirin, prasugrel) and triple-antiplatelet (aspirin, clopidogrel, and cilostazol) preparation using P2Y12 assay in patients with high on-treatment platelet reactivity…
- Trial name
- NCT03581409
- Testing
- Aspirin, Prasugrel, Clopidogrel
- Where
- South Korea
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Stroke
TENS and Spasticity in Stroke Patients
study aims to evaluate the efficacy of high and low frequency TENS on spasticity, strength and functional status in stroke patients.
- Trial name
- NCT05075109
- Testing
- High Frequency TENS, Low Frequency TENS, Task Related Training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Phenylketonurias, Nutritional and Metabolic Diseases
Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients
Phenylketonuria is a rare metabolic disease that results from the absence or near-absence activity of the enzyme phenylalanine hydroxylase, which metabolizes the amino acid phenylalanine to tyrosine in the body.
- Trial name
- NCT04969809
- Testing
- Ultrasound of the jugular veins, addition of phenylalanine-free protein substitutes
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Dementia, Motor Impairments
PERDOVE ANZIANI: a Prospective Cohort Study on Older Patients
This prospective observational cohort study aims at studying functional and clinical outcomes of patients (N = 329) admitted to 4 geriatric hospital facilities of the St John of God Order in Northern Italy during an index period…
- Conditions
- Dementia, Motor Impairments, Stroke, Thighbone Fractures
- Trial name
- NCT01699984
- Where
- 4 sites in Italy
- Volunteers
- 329 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Central Nervous System Tumors, Tumors
Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors
The prognosis of children and adolescents with high risk tumors of the central nervous system and other miscellaneous solid tumors is poor despite modern treatment protocols.
- Trial name
- NCT00607984
- Testing
- thiotepa melphalan
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Brain Tumors
Study of Massage Therapy Within a Brain Tumor Setting
The purpose of this study is to assess the feasibility and acceptability of massage therapyto examine the effects of massage therapy to explore whether psychological outcomes are associated with changes in patient reported QoL.
- Trial name
- NCT00873184
- Testing
- Massage Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
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