Clinical trials: Cerebral Disorder
Alzheimer's Disease
Study Evaluating SRA-333 in Mild to Moderate Alzheimer's Disease (AD)
To determine the safety and tolerability of multiple ascending fixed oral doses of SRA-333 in subjects with mild to moderate Alzheimer's disease.
- Trial name
- NCT00151333
- Testing
- SRA-333
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Intracranial Aneurysm
@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).
- Trial name
- @neurIST (NCT05526352)
- Where
- 22 sites in United States, Canada and 9 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Stroke, Ischemic, Thrombectomy
Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke
This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot.
- Conditions
- Stroke, Ischemic, Thrombectomy, Thrombolytic Therapy, Brain Ischemia
- Trial name
- NCT07069452
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier de Gonesse
Moyamoya Disease
Clinical Evaluation of the Safety and Efficacy of "Buyan Huan Wu Tang" Combined With Atorvastatin in the Treatment of Atypical Pneumonia
Moyamoya disease, also known as "smoky vein disease," is a relatively rare chronic form of cerebral artery occlusion. The exact cause of this condition is currently unknown.
- Trial name
- NCT07906652
- Testing
- Atorvastatin, Replenishing Five Herbs Decoction
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Objective of this study is to compare the effectiveness of routine physical therapy with and without Proprioceptive Neuromuscular Facilitation on Balance, gait and function in patients with Parkinson's disease.
- Trial name
- NCT05154552
- Testing
- Proprioceptive Neuromuscular Facilitation, Routine physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Lahore
Parkinson's Disease
An Open-Label Feasibility/Pilot Study With [123I]-IBZM SPECT (DOPA-SYN)
This study conducted to more fully evaluate the way that carbidopa/levodopa and entacapone may work in the brain. This research study uses [123I]-IBZM and dynamic SPECT imaging to determine the amount and the duration of dopamine…
- Trial name
- NCT00200447
- Testing
- carbidopa/l-dopa, carbidopa/l-dopa/entacapone, Stalevo
- Volunteers
- 3 people
- Sponsor
- Molecular NeuroImaging
Epilepsy
User Controlled Follow-up of Epilepsy
In December 2019 Vestre Viken Hospital Trust implemented user controlled epilepsy follow-up. Patients receive follow-up questions digitally twice yearly.
- Trial name
- NCT05683847
- Testing
- User controlled epilepsy follow-up by means of patient reported outcome measures (PROM)
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Vestre Viken Hospital Trust
Phenylketonurias
Study to Evaluate the Effect on Nitrogen Retention of Two Different Posology Schemes of PKU GOLIKE PLUS 3-16 and Free AAs in Patients With Phenylketonuria
This is an open-label, randomized, 4-way crossover, monocentric, controlled study in patients (3 ≤ years of age ≤ 20 )) with phenylketonuria (PKU).
- Trial name
- NCT05229549
- Testing
- GOLIKE PLUS 3-16, Free AAs
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- APR Applied Pharma Research s.a.
Parkinson's Disease
EMD 128130 for the Treatment of Parkinson's Disease
This study will evaluate the effects of an experimental drug called EMD 128130 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term treatment with levodopa.
- Trial name
- NCT00009048
- Testing
- EMD 128130, IV Levodopa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure, Arrhythmias
Comparison Study of BNP and Thoracic Impedance Measurements on Arrhythmias
It is hypothesized that elevated BNP level correlate with an elevated thoracic impedance/fluid index as measured separately by CRT-D devices and external impedance cardiography.
- Trial name
- NCT00580255
- Where
- United States
- Sponsor
- University of California, Davis
Parkinson Disease
Development of Digital Diagnostic Devices for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06663826
- Testing
- oculomotor and pupillary function assessment
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- machineMD AG
Breast Cancer, Breast Neoplasm Female
Study on Physical Activity's Relationship With Cancer and Cognition
This pilot study tests the effects of aerobic exercise training on cognitive function in breast cancer survivors (BCS). Participants will be randomized to a 12-week walking intervention or usual care.
- Trial name
- SPARCC (NCT03980626)
- Testing
- Walking
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Nebraska
Metastatic Brain Tumor, Primary Brain Tumor
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System
The NeuroBlate® System (NBS) is a minimally invasive robotic laser thermotherapy tool that is being manufactured by Monteris Medical.
- Conditions
- Metastatic Brain Tumor, Primary Brain Tumor, Epileptic/Seizure Foci, Movement Disorders
- Trial name
- LAANTERN (NCT02392078)
- Testing
- NeuroBlate System
- Where
- 26 sites in United States
- Volunteers
- 1,153 people
- Sponsor
- Monteris Medical
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- STBI (NCT06199778)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zeng Changhao
Alzheimer Disease
Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type
The purpose of this study is to learn if aripiprazole is safe and effective in the treatment of psychosis associated with dementia of the Alzheimer's type.
- Trial name
- NCT00041678
- Testing
- aripiprazole
- Where
- 6 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Obsessive-Compulsive Disorder
Deep Brain Stimulation in Severe Obsessive-compulsive Disorder
Deep brain stimulation is an established treatment for movement disorders. New indications for deep brain stimulation are under investigation, among them severe and treatment-resistant obsessive-compulsive disorder.
- Trial name
- DBS in OCD (NCT04919785)
- Testing
- Deep brain stimulation
- Volunteers
- 11 people
- Sponsor
- University Hospital, Umeå
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
RATIONALE: Taking part in a clinical trial may help children with cancer receive more effective treatment. PURPOSE: Determine why patients who are eligible for protocols made available through the Pediatric Oncology Group do not…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Leukemia
- Trial name
- NCT00002485
- Testing
- psychosocial assessment and care
- Where
- 31 sites in United States, Canada and 2 more
- Volunteers
- 359 people
- Sponsor
- Children's Oncology Group
Pain
Analgesic Effects of Expectation and Deep Brain Stimulation in Patients With Parkinson's Disease
The study investigates analgesic effects of expectations and deep brain stimulation on chronic and evoked pain in patients with Parkinson's disease.
- Trial name
- NCT04151043
- Testing
- Suggestions, Deep brain stimulation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Huntington Disease
Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease
Cellavita HD is a stem-cell therapy for Huntington's Disease. This is a first-in-human, non-randomized, phase I study in which participants with Huntington's Disease will receive three intravenous injections and will be followed…
- Trial name
- SAVE-DH (NCT02728115)
- Testing
- Cellavita HD Lower Dose, Cellavita HD Higher dose
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Azidus Brasil
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