Clinical trials: Cerebral Disorder
PKU, Hyperphenylalaninemia
Study of a National Cohort of Adult Patients With Phenylketonuria
Phenylketonuria (PKU) is a metabolic disease of genetic origin. This is a rare disease (incidence 1 / 16000 births) which is the subject of a systematic neonatal screening in France, because it is treatable by a diet low in…
- Trial name
- ECOPHEN (NCT01619722)
- Where
- 16 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Tours
Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease
Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan
Inborn errors of metabolism (IEM) are not have specific clinical signs, they masquerade as other diseases, and are difficult to diagnose using only clinical manifestations or routine laboratory tests.
- Conditions
- Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease, Citrullinemia, Argininosuccinic Aciduria
- Trial name
- NCT05910151
- Testing
- Obtaining Dry Blood Spots From Healthy Newborns (Aged 1-7 Days), Obtaining Dry Blood Spots From Healthy Children Aged 8 Days - 7 Years, Obtaining Dry Blood Spots From Healthy Children Aged 8-18 Years
- Where
- Kazakhstan
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Medical University
Parkinson Disease, Accidental Falls
Effects of Vitamin D in Parkinson's Disease (PD)
A trial to measure the effects of vitamin D (versus a placebo) on balance, gait, falls, strength, and cognition in persons with Parkinson's disease.
- Trial name
- NCT01119131
- Testing
- Vitamin D3, calcium
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- VA Office of Research and Development
Vitamin D Deficiency, Carotid Artery Diseases
Vitamin D Deficiency as Independent Predictor for Plaque Vulnerability
Role of vitamin D in cardiovascular disease is controversial. Here the investigators aimed to investigate the association of vitamin D deficiency and carotid plaque morphology as well as outcome of participants with high-grade…
- Trial name
- NCT06473337
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 332 people
- Sponsor
- Medical University of Vienna
Traumatic Brain Injury
Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Trial name
- NCT01132937
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
Developing Microbiome and Dietary Strategies Based on Chrono-nutrition for Targeting ADHD
Study objectives This project seeks to understand how an intervention based on time-restricted eating (ChronoFeeding or CF) can improve quality of life, behavior, sleep, and gut health in adults with ADHD (Attention Deficit…
- Trial name
- CronoNutriBiom (NCT07821060)
- Testing
- Circadian fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Spinal Cord Injury, Hyperalgesia, Secondary
MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI
The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and…
- Conditions
- Spinal Cord Injury, Hyperalgesia, Secondary, Hyperalgesic Sensations
- Trial name
- MRS (NCT00561782)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Brain Disorder, Home Based Rehabilitation
Effect of Untact Upper Extremity Rehabilitation Using Smart Glove for Late Subacute and Chronic Patients With Brain Disorder
The aim is to clinically validate the clinical efficacy, usability, and safety of home-based upper limb rehabilitation training using the Neofect Smart Glove by comparing the effects between a group using the home-based Neofect…
- Trial name
- brain disorder (NCT06837324)
- Testing
- home-based Neofect Smart Glove, home-based occupational therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Stroke
Robotic Exosuit Augmented Locomotion (REAL)
Previous studies of the exosuit technology have culminated in strong evidence for the gait-restorative effects of soft robotic exosuits for patients post-stroke by means of substitution for lost function.
- Trial name
- REAL (NCT04818424)
- Testing
- Soft exosuit, Gait training without exosuits
- Where
- 3 sites in United States
- Sponsor
- Lou Awad, PT, DPT, PhD
Parkinson Disease
A Study of the Efficacy of IAMT as an Assessment Tool for Prediction of Progression of Parkinson's Disease
The primary objective of this proposal is to examine the efficacy of Improvised Active Music Therapy (IAMT) sessions as an early novel tool for cognitive and motor assessment for individuals with Parkinson's Disease (PD) in…
- Trial name
- Music Therapy (NCT05971459)
- Testing
- Improvised Active Music Therapy
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Parkinson Disease
Transcutaneous Afferent Patterned Stimulation (TAPS) for Reduction of Parkinson's Disease (PD) Related Action Tremor
Demonstrate safety and efficacy of TAPS delivered by a Cala device as a treatment for action tremor in subjects with Parkinson's disease hand tremor
- Trial name
- NCT05012579
- Testing
- Cala Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cala Health, Inc.
Lung Cancer
Temozolomide in Patients With Progressive or Recurrent Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effect of temozolomide in patients with progressive or recurrent stage…
- Trial name
- NCT00003062
- Testing
- temozolomide
- Where
- 5 sites in Italy, Netherlands and 3 more
- Volunteers
- 70 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cerebral Palsy
Integrated Management of Pronation Deformity in Cerebral Palsy
Pronation deformity is a very common problem in children with cerebral palsy. This deformity is usually has neural and non-neural aspects.
- Trial name
- NCT03472261
- Testing
- Botulinum toxin type A, Upper extremity orthoses, Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Kocaeli University
Parkinson Disease
Use of BART Coupled With EEG in the Early Diagnosis of Behavioral Disorders in Parkinson's Disease
The Balloon Analogue Risk Task [BART] is an experimental task modelizing risky behaviors. In Parkinson disease, the correlation between BART and modifications of cerebral activity in ventral striatum has been shown.
- Trial name
- COMPARE (NCT05640986)
- Testing
- BART-EEG at V1 + V2, BART-EEG at V1 only
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Stroke, Rehabilitation
Effect of Intensive Language Therapy in Subacute Stroke Patients
Early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications.
- Conditions
- Stroke, Rehabilitation, Language
- Trial name
- NCT03168373
- Testing
- language rehabilitation therapy
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Ischemic Stroke, Stroke
Clinical Evaluation of EEG Device for the Triage of Stroke Patients in the Ambulance
Endovascular thrombectomy (EVT) is the standard treatment for large vessel occlusion (LVO) strokes, but it can only be performed in specialized hospitals.
- Conditions
- Ischemic Stroke, Stroke, Cardiovascular Diseases, Vascular Diseases
- Trial name
- CROSSROADS-EEG (NCT06871969)
- Testing
- Dry electrode EEG
- Where
- Netherlands
- Volunteers
- 275 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation
Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
The main purpose of this project is to determine the impact of atrial fibrillation interventions (catheter ablation and exercise training) on circulating BDNF concentrations in patients with atrial fibrillation.
- Trial name
- NEURO-AF (NCT02627183)
- Testing
- Catheter ablation, Exercise training
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acromegaly
Comparable Effects of Lanreotide Autogel and Octreotide LAR on GH, IGF-I Levels and Patient Satisfaction
The morbidity and the mortality in acromegalic patients closely correspond to growth hormone (GH) levels and therefore efficient long-term treatment is important.
- Trial name
- NCT00145405
- Testing
- Lanreotide Autogel and Octreotide LAR
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Cerebrovascular Accident
Can Arm and Leg Cycling Exercise Improve Walking After Stroke
It has been found that arm and leg cycling is similar to walking. Thus, the objective of this research is to determine if arm and leg cycling can be used to improve walking ability in a post-stroke population.
- Trial name
- NCT02316405
- Testing
- Arm and Leg Cycling Exercise for Walking after Stroke
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Victoria
Parkinson's Disease
High and Low Dose Carbidopa Treatment of Parkinson's Disease
Hypothesis: We hypothesize that carbidopa in daily doses of 450mg will enter the central nervous system and partially inhibit AAAD, thereby reducing the decarboxylation of exogenous levodopa to dopamine, and thereby blunt the…
- Trial name
- NCT01399905
- Testing
- carbidopa
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Oregon Health and Science University
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