Clinical trials: Cerebral Disorder
Phenylketonuria, PKU
Moderate Intensity Exercise and Phenylketonuria
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout…
- Trial name
- NCT01904708
- Testing
- Acute Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Cerebral Palsy
Mobility Exercises for Gait (MEG Neuroplasticity Project)
This study is directed at identifying a the neurophysiological changes seen in children with cerebral palsy (CP) after undergoing physical therapy.
- Trial name
- NCT03555708
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Malignant Brain Neoplasm, Malignant Glioma
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
The phase I/II trial studies the side effects and best dose of panitumumab-IRDye800 in diagnosing participants with malignant glioma who undergo surgery.
- Trial name
- NCT03510208
- Testing
- Near-Infrared Fluorescence Imaging, Panitumumab, Panitumumab-IRDye800
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Stanford University
Traumatic Brain Injury
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).
- Trial name
- NCT00893789
- Testing
- Armodafinil
- Where
- 73 sites in United States, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- Cephalon, Inc.
Obstructive Sleep Apnea
Brain Fog in Sleep Apnea
Objective: This observational, cross-sectional pilot study aims to assess "Brain Fog" (cognitive symptoms impacting memory, attention, and concentration) in severe Obstructive Sleep Apnea (OSA) patients.
- Trial name
- BF -OSA (NCT06664450)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dysphagia
Neuromuscular Electroestimulation and Respiratory Muscle Training in Subacute Stroke
This study, part of a larger research project (The Retornus Study), is aimed to evaluate new strategies to optimize rehabilitation outcomes in dysphagic stroke patients.
- Trial name
- NCT02473432
- Testing
- RMT + usual care, NMES, Usual care
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Parc de Salut Mar
Cerebral Palsy, Muscle Hypertonia
Evaluation of the Effect of the Presence Of Clowns on Pain and Anxiety Seen During Injections Botulinum Toxin in Child
In children requiring botulinum toxin injections, improving supervisory procedures of injection sessions to reduce pain and improve the experience of this invasive procedure is needed.
- Trial name
- CLOWN-TOX (NCT03149263)
- Testing
- distraction
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
PARKINSON DISEASE (Disorder)
Auricular Vagus Nerve Stimulation Combined With Rehabilitation in Parkinson's Disease
Parkinson's disease (PD) is a progressive, neurodegenerative movement disorder characterized by a combination of motor and non-motor symptoms.
- Trial name
- NCT07440563
- Testing
- Neurological Physiotherapy and Rehabilitation Combined with Active Vagus Nerve Stimua
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
Alzheimer Disease
Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease
The goal of this study is to examine whether the administration of estrogen to post-menopausal women and women with mild to moderate Alzheimer's disease will enhance their memory and their capacity for learning.
- Trial name
- NCT00006399
- Testing
- Donepezil, Estrogen, Progesterone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Center for Research Resources (NCRR)
Acute Ischemic Stroke
Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients With Ischemic Stroke
The purpose of this study is to determine the impact of remote ischemic conditioning on cerebral hemodynamics in patients with ischemic stroke.
- Trial name
- RICCH-IS (NCT05915832)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yi Yang
Parkinson's Disease, DBS
Prospective Study to Compare Results of STN-DBS Between Early Treated and Late-treated PD Patient
The aim of this study is to investigate the impact of DBS not only no motor outcomes, but also on neuropsychological and psychiatric aspects and on quality of life in young patients with a short history of disease.
- Conditions
- Parkinson's Disease, DBS, Deep Brain Stimulation, STN
- Trial name
- DeBraStE (NCT01274832)
- Testing
- Deep Brain Stimulation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Intellectual Disability, Autism
Sensors for Communication for Persons Who Cannot Communicate Unequivocally
Some persons with intellectual disability or comprehensive cerebral palsy cannot communicate unequivocally how they are, how they react to situations and people, whether they are in pain or experience discomfort, anger or fear.
- Conditions
- Intellectual Disability, Autism, Cerebral Palsy
- Trial name
- NCT04199299
- Testing
- Heart rate and respiration rate sensors
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Parkinson Disease, Parkinsonian Disorders
Usefulness of α-synuclein as a Marker for Early Diagnosis of Parkinson's Disease in Skin Biopsy.
Parkinson's disease (PD) is a degenerative disease that can be difficult to diagnose. The clinicopathological studies had demonstrated a 76% accuracy in the clinical diagnosis of PD.
- Trial name
- NCT01380899
- Testing
- Biopsy of skin
- Where
- Mexico
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Acute Ischemic Stroke
A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant
This is a phase II, open-label, single-arm, exploratory study to evaluate the intracranial arterial recanalization of multiple doses of LT3001 drug product in participant with acute ischemic stroke (AIS)
- Trial name
- NCT07890298
- Testing
- LT3001 Drug Product
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Cerebral Palsy, Parent-Child Relations
Association Between Functional Impairment and Parenting Stress Among Children Diagnosed with Diplegic Cerebral Palsy
1. To find out the relation between the severity of ADL limitation in diplegic CP children and the level of parents' stress. 2. To detect the correlation between the PS level to the different domains of ADL limitation. 3.
- Trial name
- NCT04938063
- Testing
- Assessing the correlation between Functional Impairment and Parenting Stress
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Cairo University
Metastatic Melanoma, Pulmonary Metastases
Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma
This is a Phase 1b/2 study designed to evaluate combination of the human T-cell cytokine Interleukin-2 (IL-2) and a checkpoint inhibitor Ipilimumab immediately following a course of hypofractionated palliative radiation therapy…
- Conditions
- Metastatic Melanoma, Pulmonary Metastases, Hepatic Metastases, Brain Metastases
- Trial name
- NCT03297463
- Testing
- Interleukin-2 & Ipilimumab (P-Ib), Interleukin-2 & Ipilimumab (P-II)
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
CDKL5 Deficiency Disorder
The Association Between Fever and CDKL5 Deficiency Disorder: a Nationwide Survey
The primary objective of this research is to study the effects of fever on seizure activity in patients with CDKL5 deficiency disorder
- Trial name
- NCT06663163
- Testing
- Observation
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Amyloid Angiopathy
Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy
A pre-post study will be conducted to assess whether treatment with LXB, nVNS or a combination of both interventions can enhance the clearance of Aβ in patients with CAA.
- Trial name
- Clear-Brain (NCT06421532)
- Testing
- XYWAV, gammaCore Sapphire
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Cerebrovascular Accident
Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
The goal of this study is to evaluate the effectiveness and safety of field-initiated magnesium sulfate in improving the long-term functional outcome of patients with acute stroke.
- Trial name
- FAST-MAG (NCT00059332)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Jeffrey L. Saver
Stroke
Applicability of Robotic Devices, Virtual and Augmented Reality in the Rehabilitation of People With Stroke During Treadmill Training
Objective assessment of clinical symptoms, mobility and quality of life changes resulting from stroke and determination of changes resulting from therapies.
- Trial name
- NCT07350798
- Testing
- High Intensity Training, Robot Assisted Treadmill Training, Treadmill Training with Virtual and Augmented Reality
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
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