Clinical trials: Cerebral Disorder
Medication-Induced Dyskinesia
Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia
This is a double-blind, randomized, placebo-controlled Phase 2a study evaluating the safety, tolerability, and preliminary efficacy of up to 2 mg/day (1 mg BID) of NLX-112 versus placebo in patients with moderate to severe L-DOPA…
- Trial name
- NCT05148884
- Testing
- NLX-112
- Where
- 5 sites in Sweden
- Volunteers
- 27 people
- Sponsor
- Neurolixis SAS
Refractory Epilepsy, Arrhythmia
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population, accounting for 10-50% of deaths for…
- Conditions
- Refractory Epilepsy, Arrhythmia, Sudden Death
- Trial name
- NCT00203333
- Testing
- Medtronic REVEAL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Brain Tumor
Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors
This research study is studying a drug called Demeclocycline that may help brain surgeons see tumors with a microscope during surgery.
- Trial name
- NCT02740933
- Testing
- Demeclocycline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Cerebral Arteriovenous Malformation
Lovastatin for Treatment of Brain Arteriovenous Malformations
The purpose of this pilot study is to evaluate the disease-modifying efficacy of lovastatin in patients with brain arteriovenous malformation.
- Trial name
- NCT04297033
- Testing
- Lovastatin
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimers Disease
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies.
- Trial name
- TRAVELLER (NCT07177352)
- Testing
- No Intervention
- Where
- 234 sites in United States, Argentina and 13 more
- Volunteers
- 80,000 people
- Sponsor
- Hoffmann-La Roche
Carotid Stenosis
Gadobutrol Enhanced MRA of the Supra-aortic Vessels
Subjects referred for a routine CTA (computed tomography angiography) or MRA (magnetic resonance angiography) will be invited to participate in the study and subjects will be involved in the study for between 2 and 12 days.
- Trial name
- GEMSAV (NCT01344447)
- Testing
- Gadobutrol (Gadovist, BAY86-4875)
- Where
- 56 sites in United States, Argentina and 12 more
- Volunteers
- 479 people
- Sponsor
- Bayer
Carotid Artery Diseases
Digital Variance Angiography for Contrast Media Dose Reduction in Carotid Artery Stenting
Digital Variance Angiography (DVA) is a new tool in medical imaging with a proven image quality reserve (1, 2). Previous studies have demonstrated the quality reserve of DVA in angiographic studies (1, 2), which allowed us to…
- Trial name
- NCT04792255
- Testing
- Carotid artery stenting with standard contrast media protocol, Carotid artery stenting with reduced contrast media protocol, Carotid Duplex Ultrasound
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Kinepict Health Ltd.
Parkinson Disease
High Frequency and Intensive Prevention Program
The treatment of PD has made considerable advances in recent years with respect to drug therapies, as well as many new physiotherapy and drug-based methods, and there have also been great improvements in therapy thanks to deep…
- Trial name
- NCT04103255
- Testing
- High frequency and intensive prevention program
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Blepharospasm, Focal Dystonia
Brain Stimulation to Treat Blepharospasm or Meige Syndrome
This research study will examine whether magnetic or electrical stimulation of the brain can improve the involuntary closure of the eyelids in patients with blepharospasm or Meige syndrome; conditions that belong to a group of…
- Trial name
- NCT00411255
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Ischemia, Hemiplegic Patients With Stroke
Using fMRI and sEMG to Evaluate the Effects and Mechanism on Abdominal Acupuncture Combined With Upper Limb Rehabilitation Training on Brain Plasticity of Hemiplegic Patients With Stroke
Using random number method to categorize the selected first onset patients with stroke who meet the inclusion criteria into 3 groups.The patients were randomly divided into treatment group A(abdominal acupuncture+upper limb…
- Conditions
- Brain Ischemia, Hemiplegic Patients With Stroke, Image Science, Electrophysiology of Neuromuscular
- Trial name
- NCT03712085
- Testing
- Abdominal acupuncture
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 66 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Middle Cerebral Artery Aneurysm
Risk Factors of Middle Cerebral Artery Aneurysm.
According to the current view, cerebral aneurysms are acquired degenerative lesions resulting from hemodynamic stress. This single-center case-control study will be carried out at the Department of Neurosurgery, Regional Hospital…
- Trial name
- MCAA (NCT03493035)
- Testing
- Computed tomography angiography (3D CTA), Transcranial color-coded sonography (TCCS)
- Where
- Poland
- Volunteers
- 190 people
- Sponsor
- Medical University of Silesia
Cerebral Palsy
Validity and Reliability of the Sitting Assessment Scale in Cerebral Palsy
The Sitting Assessment Scale is a valid and reliable scale that evaluates sitting balance in Cerebral Palsy (CP). The validity and reliability study of the scale has been done, but it has not been adapted to Turkish language.
- Trial name
- NCT05621135
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Gaziantep Islam Science and Technology University
Atrial Fibrillation, Stroke, Ischemic
Echocardiographic Predictors of Atrial Fibrillation
This prospective study aims to identify the diagnostic accuracy of echocardiographic predictors of atrial fibrillation in patients with ESUS (embolic stroke of undetermined source) or TIA (transient ischemic attack).
- Conditions
- Atrial Fibrillation, Stroke, Ischemic, Embolic Stroke of Undetermined Source, TIA, Brain
- Trial name
- EPAF-7 (NCT05044208)
- Testing
- ECG monitoring
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Parkinson Disease
Words Generation in Compulsives Gamblers and Parkinson's Disease Patients
The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
- Trial name
- FLUENCE (NCT01888276)
- Testing
- evaluation of word generation and of motivation
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Stroke, Stroke, Acute
Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke
The primary objective of this study is to determine the efficacy of a single intravenous infusion of unrelated donor umbilical cord blood (UCB) for improving functional outcomes in patients with ischemic stroke.
- Conditions
- Stroke, Stroke, Acute, Brain Injury, Acute
- Trial name
- CoBIS 2 (NCT03004976)
- Testing
- Umbilical Cord Blood
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Joanne Kurtzberg, MD
Caregiving Stress, Dementia
Providing Evidence-Based Approaches for Caregiver Stress Study
The purpose of this preliminary study is to examine the effects of adult day service use on subjective and physiological measures of stress in 50 Black informal caregivers for individuals with dementia (IWD).
- Trial name
- PEACE (NCT06451250)
- Testing
- Adult Day Service use for family member with dementia
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Ischemic Stroke
Speech and Language Therapy After Stroke
Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.
- Trial name
- NCT00713050
- Testing
- Imitate Therapy
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Memory Disorders, Dementia
Maximizing Independence at Home (MIND at Home)
Funded by a unique private philanthropy and public coalition through THE ASSOCIATED: Jewish Community Federation of Baltimore, this project seeks to develop effective ways to deliver dementia care to older adults with memory…
- Trial name
- NCT01283750
- Testing
- care coordination
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Johns Hopkins University
Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases
This phase II trial studies how well stereotactic radiosurgery works in treating patients with melanoma that has spread to more than 3 places in the brain.
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Trial name
- NCT01644591
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Use Disorder, Ketosis
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use…
- Trial name
- KABA (NCT06807918)
- Testing
- Kenetik, magnetic resonance imaging scan, Alcohol bar lab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.