Clinical trials: Cerebral Disorder
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Post-Traumatic Headache
The Effect of Galcanezumab-gnlm on Post-Traumatic, Migrainous Headaches
The goal of this pilot, open-label clinical trial is to determine whether the addition of galcanezumab-gnlm to stable conventional headache treatment will reduce the number of monthly migraine days in participants who have…
- Trial name
- NCT06901518
- Testing
- Galcanezumab-Gnlm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Albany Medical College
Stroke
Clinical Efficacy of Luna EMG Robot Therapy for Patients After Stroke
A lot of studies prove that rehabilitation with the use of modern devices accelerates the recovery of function in patients after stroke.
- Trial name
- NCT03888118
- Testing
- Luna EMG
- Volunteers
- 60 people
- Sponsor
- Rehamed Center
Parkinson Disease
A Pharmacokinetic Study of Levodopa and Carbidopa Intestinal Gel in Subjects With Advanced Parkinson's Disease
A Pharmacokinetic Study of Levodopa and Carbidopa Intestinal Gel in Subjects with Advanced Parkinson's Disease.
- Trial name
- NCT01484990
- Testing
- Levodopa-Carbidopa
- Volunteers
- 19 people
- Sponsor
- AbbVie
Alzheimer Disease, Dementia
Shanghai At Risk for Alzheimer's Disease: a Cohort Study
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: cognitive changes of subjects at high risk of AD as ageing…
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment
- Trial name
- SHARAD (NCT05597410)
- Where
- China
- Volunteers
- 3,418 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Parkinson Disease
Pedunculo-Pontin Nucleus (PPN) - Deep Brain Stimulation (DBS) in Gait and Balance Disturbance in Parkinson's Disease (PPN-GAB-PARK Study)
Disturbance of posture, gait and balance usually appear several years after Parkinson's disease (PD) onset. These axial signs, generally resistant to conventional drug and non-drug treatment, can generate a loss of autonomy and…
- Trial name
- NCT00821743
- Testing
- Deep brain stimulation electrode
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease, Other Neurological Disorders
Prevalence of Visual Dysfunction in Neurological Disorders
The objective is to determine the prevalence of visual dysfunction in People with Parkinson's Disease (PwP). The investigators will administer the: Visual Impairment in Parkinson's Disease Screen and Revised-Self-Report…
- Conditions
- Parkinson Disease, Other Neurological Disorders, Healthy
- Trial name
- NCT04836715
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of Florida
Overweight and Obesity, Time Restricted Feeding
Fasting ENHANCE Pilot Study
Grounded in the principles of geroscience, the proposed Fasting ENHANCE study will test whether a time restricted eating (TRE) regimen can improve cognitive function and other aspects of successful aging in a safe and sustainable…
- Conditions
- Overweight and Obesity, Time Restricted Feeding, Alzheimer Disease
- Trial name
- NCT05732935
- Testing
- Time Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Intracranial Arteriovenous Malformations (AVM)
Protocol for Staged Stereotactic Radiosurgery for Large Arteriovenous Malformations
Stereotactic radiosurgery is a well established treatment option for arteriovenous malformations (AVMs). The potential complications related to radiosurgery are well documented and are predominately related to radiation effects…
- Trial name
- NCT02576535
- Testing
- Fractionated stereotactic radiosurgery, Leskell gamma unit
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Breast Cancer
Brain Mets - Capecitabine Plus Sunitinib and WBRT
The purpose of this study is to assess the efficacy and safety of concurrent whole brain radiotherapy (WBRT) and capecitabine followed by combination capecitabine and sunitinib in treating patients with CNS metastases from breast…
- Trial name
- NCT00570908
- Testing
- sunitinib, capecitabine, WBRT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Baylor Breast Care Center
Cerebral Palsy
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy, Prospective, Randomized, Open-label Trial
- Trial name
- NCT04012125
- Testing
- flexible thoracolumbar brace
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Seoul National University Hospital
Parkinson Disease
WD-1603 PK Study Under Fasting and Fed Conditions in Healthy Subjects
The Phase 1 PK study is planned to evaluate the food effect on WD-1603 pharmacokinetics
- Trial name
- NCT04513340
- Testing
- WD-1603 CARBIDOPA and LEVODOPA EXTENDED-RELEASE TABLETS
- Where
- India
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hong Kong WD Pharmaceutical Co., Limited
Epilepsy
Single Dose Crossover Comparative Bioavailability Study of Eslicarbazepine Acetate Versus To-be-marketed Formulation
Single center, randomized, single dose, laboratory-blinded, 2-period, 2-sequence, crossover design
- Trial name
- NCT02283840
- Testing
- BIA 2-093
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Migraine
Metformin for the Prevention of Episodic Migraine (MPEM)
The investigators will evaluate the safety and efficacy of metformin for preventive treatment of migraine in a randomized, double-blind, placebo-controlled, crossover trial.
- Trial name
- MPEM (NCT02593097)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma
Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma
Phase I/II trial to study the effectiveness of erlotinib in treating patients who have recurrent malignant glioma or recurrent or progressive meningioma.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma
- Trial name
- NCT00045110
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- 7 sites in United States
- Volunteers
- 136 people
- Sponsor
- National Cancer Institute (NCI)
Acute Stroke, Ischemic Stroke, Acute
Tandem Occlusion After Emergent Stenting in Acute Ischemic Stroke
In acute ischemic stroke due to tandem occlusion, the emergent stenting has recently become an endovascular treatment option combining with mechanical thrombectomy to achieve recanalization.
- Trial name
- TOESIS (NCT06120218)
- Testing
- Emergent Stenting
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Can Tho Stroke International Services Hospital
Epilepsy, Diabetic Nephropathy
Study on the Population Pharmacokinetics of Levetiracetam in Epileptic Patients With Diabetic Kidney Disease
The individualized drug delivery system of levetiracetam based on population pharmacokinetics and quantitative pharmacology model in patients with epilepsy complicated by diabetic kidney disease was established.
- Trial name
- NCT05330390
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Shandong University
Post Stroke Fatigue, Stroke
How to Identify Fatigue in Stroke Patients
This study will translate an English case definition of poststroke fatigue and validate it against the Multidimensional Fatigue Questionnaire-20 and the Fatigue Severity Scale
- Trial name
- NCT03034590
- Testing
- questionnaire
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Herlev Hospital
Cerebrovascular Accident, Stroke, Acute
Fabry and Cardiomyopathy (FaCard)
Primary objective and endpoint is the analysis of the long-term course of lyso-Gb3 and its clinical correlation to the progression of the cardiomyopathy in N215S-Fabry patients.
- Conditions
- Cerebrovascular Accident, Stroke, Acute, Cerebral Stroke
- Trial name
- FaCard (NCT01429597)
- Where
- Germany
- Sponsor
- CENTOGENE GmbH Rostock
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