Clinical trials: Cerebral Disorder
Migraine
Vagal Nerve Stimulation and Pain Frequency, Intensity in Chronic Migraine
This study is being conducted to address the need for effective and well-tolerated interventions in preventing chronic migraine attacks.
- Trial name
- NCT06191016
- Testing
- Vagal nerve stimulation
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Riphah International University
Alzheimer's Disease
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
This is a multicentre, randomized, double-blind, placebo-controlled, parallel group Phase II study to evaluate the efficacy and safety of VHB937 in participants with early AD followed by an Extension.
- Trial name
- NCT07094516
- Testing
- VHB937
- Where
- 73 sites in United States, Australia and 13 more
- Volunteers
- 97 people
- Sponsor
- Novartis Pharmaceuticals
Traumatic Brain Injury
Transcranial Doppler on Admission of Patients With Mild to Moderate Traumatic Brain Injury
Patients with mild to moderate traumatic brain injury (TBI) are at risk for secondary neurological deterioration. Their outcome within the first week after injury could be predicted by clinical signs, brain CT scan and…
- Trial name
- TCD (NCT01291706)
- Testing
- Transcranial Doppler
- Where
- 21 sites in France
- Volunteers
- 369 people
- Sponsor
- University Hospital, Grenoble
Migraine Headache
A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache
Study 20170703 is a phase 4, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of erenumab against placebo in participants with chronic migraine (CM) who have a history of at…
- Trial name
- NCT03971071
- Testing
- Erenumab 70 mg, Erenumab 140 mg
- Where
- 94 sites in United States, Australia and 10 more
- Volunteers
- 620 people
- Sponsor
- Amgen
Pituitary Adenoma
Predictive OCTA Biomarkers After Endoscopic Endonasal Pituitary Surgery
This study evaluates the structural parameters, by spectral domain optical coherence tomography (OCT), retinal vessel density, using OCT angiography, and visual acuity in patients that received endoscopic endonasal approach for…
- Trial name
- NCT04840771
- Testing
- Endoscopic Endonasal Pituitary Surgery
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Federico II University
Grief
A Grief Support App for Adults Experiencing Bereavement
Losing a loved one is a difficult experience. Some people may require psychological support, but even for those who do not, grief can often feel overwhelming.
- Trial name
- NCT07862244
- Testing
- Self-guided grief app (Daybreak), Waiting list
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Pituitary Macroadenoma
Radioactive Iodine Implants for Pan-invasive Pituitary Macroadenomas
This study is a single arm Phase II pilot trial. Patients enrolled on the trial will undergo implantation of high activity iodine-125 seeds into their pituitary adenoma.
- Trial name
- NCT01444209
- Testing
- Iodine Implants
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injuries, Multiple Sclerosis
GentleCath Air (Urinary Self-catheterization) - Pain in Female Patients With Neurological Vesico-sphincter Disorders
The purpose of this study is to evaluate the rate of occurrence of urethral pain in female patients with neurological vesico-sphincter disorders whilst performing self-catheterization using GentleCath™ Air catheters.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Parkinsonian Disorders, Allodynia
- Trial name
- FollowAir (NCT04847609)
- Testing
- GentleCath™ Air catheter
- Sponsor
- ConvaTec Inc.
Alzheimer Dementia (AD), Elderly
Therapy of Alzheimer's Disease With Neurofeedback
The project aims to investigate in patients of Alzheimer's disease in a prodromal state (early state of the disease) compared to healthy subjects whether neurofeedback training with functional MRI (fMRI) can improve cognitive…
- Trial name
- NCT03070821
- Testing
- rtfMRI neurofeedback training, 3T MRI
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Parkinson Disease
Consolidation of Motor Learning of Writing Skills and Its Related Brain Activity Changes in Parkinson's Disease
The basal ganglia play an important role in motor learning, especially during the consolidation phase of motor learning. This raises the question whether it is possible to sustain learning increments in a neurodegenerative…
- Trial name
- NCT02288052
- Testing
- Writing program, Stretch & Relaxation program
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- KU Leuven
Cognitive Impairment, Subjective Cognitive Decline
Brain Health Together: Development and Pilot Test
The objectives of this study were to develop and pilot-test Brain Health Together (BHT), a 12-week, virtual-group program that combines our evidence-based, mind-body, group movement program with brain health education and…
- Conditions
- Cognitive Impairment, Subjective Cognitive Decline, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06914947
- Testing
- Brain Health Together
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Polytrauma, Traumatic Brain Injury
Age, Traumatic Brain Injury and Injury Severity as Independent Risk Factors for In-Hospital Mortality in Polytrauma Patients.
In this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from January 2012 to December 2015.
- Trial name
- NCT04335838
- Testing
- retrospective analysis
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Paralytic Stroke, Cough
Diaphragmatic Function in Stroke Patients.
This study attempts to elucidate whether stroke patients with dysphagia have reduced diaphragm movement during voluntary coughing, and also during deep inspiration and expiration than stroke patients without dysphagia.
- Trial name
- NCT01637649
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health
Cerebral Palsy, Spastic
Stretching in Children and Adolescents With Spastic Cerebral Palsy
The primary aim of this study is to gain knowledge about both the effects of a single bout of static and proprioceptive neuromuscular facilitation (PNF) stretching and the effects of 8-week static and PNF stretching training on…
- Trial name
- NCT04570358
- Testing
- Static stretching, Proprioceptive neuromuscular facilitation stretching
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- University of Graz
Cognitively Normal, Mild Cognitive Impairment
Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease
The overall goal of this imaging trial is to evaluate crosssectional difference and longitudinal changes of [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in cognitively normal individuals, and…
- Conditions
- Cognitively Normal, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03903211
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jae Seung Kim
Aortic Aneurysm
The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion
There is a need to understand how long anesthetic drugs last in the brain during surgery on the ascending aorta or aortic arch. Drugs can have a prolonged effect when blood temperature is made cold therefore the influence of…
- Trial name
- NCT00494598
- Testing
- Sufentanil
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Cervical Spinal Cord Injury, Tetraplegia
Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation
Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots.
- Trial name
- UP2 (NCT05665998)
- Testing
- ARC-BSI Cervical system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Alzheimer Disease
Renji Alzheimer's Disease Neuroimaging Cohort Study
This study focuses on the population of Alzheimer disease (AD). Based on Aβ(A)-Tau(T)-Vascular(V)-Neurodegeneration(N) (ATV(N))-AD evaluation system of NIA-AA Association, it can accurately diagnose and predict early AD.
- Trial name
- NCT05433363
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
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