Clinical trials: Cerebral Disorder
Stroke
Dynamic-orthosis Programs for Stroke Hand Function
This study aims to investigate the training benefits of modular 3D printed dynamic orthoses on upper limb function in stroke survivors.
- Trial name
- NCT06271187
- Testing
- Dynamic-orthosis, Traditional stroke occupational therapy training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Brain Injuries
Computer-based Attention Training in Patients With Acquired Brain Injury
Investigates computer based cognitive rehabilitation and training using the N-back task with a Visual Search task as an active control.
- Trial name
- NCT02399293
- Testing
- N-back, Visual Search
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
TBI (Traumatic Brain Injury)
Traumatic Brain Injury in Veterans and Near-Infrared Phototherapy
This is a proof-of-concept study designed to demonstrate whether increases in cerebral blood flow, improvements in brain functioning, and reductions in symptomology associated with traumatic brain injury (TBI) can result from…
- Trial name
- NCT02635516
- Testing
- Near-Infrared Phototherapy
- Volunteers
- 13 people
- Sponsor
- Cerehealth Corp.
Alzheimer's Disease
Preliminary Efficacy and Safety Study of ST101 Plus Aricept in Alzheimer's Disease
This study will investigate the ability of ST101 to improve memory in people with Alzheimer's disease who currently receive 10 mg Aricept® (donepezil) per day. This study also will examine the safety and tolerability of the drug.
- Trial name
- NCT00842816
- Testing
- ST101
- Where
- 30 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- Sonexa Therapeutics, Inc.
Alzheimer Disease
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the…
- Trial name
- AMPAlz (NCT06880406)
- Testing
- MMSE and blood draw
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hereditary Ataxia
Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10)
OBJECTIVES: I. Clinically evaluate members from families with a dominantly inherited ataxia and collect blood, skin and muscle samples for detailed molecular studies. II.
- Trial name
- NCT00004306
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Office of Rare Diseases (ORD)
Fabry Disease
A Phase I, Randomized, Single-Blind, Four-Period Cross-Over, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Single Oral Doses of GR181413A/AT1001 in Healthy Japanese Subjects
GR181413A/AT1001 (migalastat hydrochloride) is a low molecular weight iminosugar, an analog of the terminal galactose group that is cleaved from the substrate GL-3.
- Trial name
- NCT01853852
- Testing
- GR181413A/AT1001 solution, GR181413A/AT1001 capsule, Potable water
- Where
- Australia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Amicus Therapeutics
Brain Cancer, Brain Neoplasm, Primary
IDH1 Peptide Vaccine for Recurrent Grade II Glioma
Potential subjects with progressive Grade II primary brain tumor that have IDH1 positive testing from the primary tumor (initial diagnosis) will be offered this treatment study in order to test the safety of the PEPIDH1M vaccine…
- Conditions
- Brain Cancer, Brain Neoplasm, Primary, Brain Neoplasms, Recurrent, Brain Tumor
- Trial name
- RESIST (NCT02193347)
- Testing
- PEPIDH1M vaccine, Tetanus-Diphtheria Toxoid (Td), Temozolomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Katy Peters, MD, PhD
Ornithine Transcarbamylase Deficiency
Phase 1b Study to Assess Safety, Tolerability, and Pharmacokinetics of ARCT-810 in Stable Adult Subjects With Ornithine Transcarbamylase Deficiency
Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-810 in clinically stable patients (stable on standard of care treatment, e.g.
- Trial name
- NCT04442347
- Testing
- ARCT-810
- Where
- 8 sites in United States
- Volunteers
- 16 people
- Sponsor
- Arcturus Therapeutics, Inc.
Acceptance and Commitment Therapy, Caregiver Burden
Acceptance and Commitment Therapy (ACT) Tele-Counselling
A randomized 2-group controlled trial will be conducted to explore the potential effect and potential feasibility of a new Acceptance and Commitment Therapy (ACT) tele-counselling program to improve mental health services for…
- Conditions
- Acceptance and Commitment Therapy, Caregiver Burden, Digital Health, Technology
- Trial name
- NCT05385458
- Testing
- ACT Intervention, Usual Care
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Aphasia, Stroke
Can Listening to Music Improve Attention and Language After Post-Stroke Aphasia?
The goal of this clinical trial is to learn if a music-based intervention can acutely improve three types of attention (alerting, orientating, executive control) in people with aphasia following a stroke.
- Conditions
- Aphasia, Stroke, Stroke and Aphasia, Stroke Hemorrhagic
- Trial name
- NCT07198048
- Testing
- Music-Based Therapy for Post Stroke Aphasia, Audiobook Intervention for Post Stroke Aphasia
- Volunteers
- 45 people
- Sponsor
- Purdue University
Acute Ischemic Stroke
Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models
This prospective, multicenter, observational cohort study aims to evaluate the safety and effectiveness of intravenous tenecteplase (rhTNK-tPA) in patients with acute ischemic stroke managed under different transfer models.
- Trial name
- NCT07897955
- Testing
- tenecteplase
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Fujian Medical University Union Hospital
Intracranial Aneurysm
Safety & Performance of the World Medica World Diverter Embolization Device
The objective of this study is to investgiate the safety and clinical performance of the World Diverter Emoblization Device for the endovascular treatment of wide-neck (neck width ≥ 4 mm or dome-to-neck ratio <2) or fusiform…
- Trial name
- NCT07339358
- Testing
- Flow diverter implantation
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- World Medica USA, LLC
Stroke, Traumatic Brain Injury
Validation of an Obstacle Course Used in Patients With Muscle Tightness
This study is being conducted to compare healthy patients versus patients with muscle tightness in their leg(s) after an acquired brain injury using walking trials time, a balance test, and foot pressure data.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis, Spasticity
- Trial name
- NCT00776048
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injury
Effect of Low-Dose Baclofen Administration on the GH-IGF1 Axis Study
Insulin-like growth factor I (IGF-I) is used as a measure of the body's ability to produce growth hormone. Growth hormone is important for muscle tissue as well as many other tissues in the body.
- Trial name
- NCT00871455
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
High Grade Gliomas, Hypoxia Brain
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response
High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment.
- Conditions
- High Grade Gliomas, Hypoxia Brain, Glioblastoma (GBM), Brain Neoplasms, Adult
- Trial name
- BRIGHTER (NCT07670455)
- Testing
- Oxygen-Enhanced MRI (OE-MRI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Alzheimer's Disease
An Evaluation of Low Level Laser Light Therapy on Improving the Symptoms of Alzheimer's Disease
This study evaluates the effect of applying low level laser light therapy to individuals with mild to moderate Alzheimer's disease to see if it may improve their memory, thinking and behaviors.
- Trial name
- NCT02537626
- Testing
- Erchonia ALS Laser
- Where
- 2 sites in Mexico
- Volunteers
- 43 people
- Sponsor
- Erchonia Corporation
Ischemic Stroke, Transient Ischemic Attack
Platelet Aggregation Function-Guided De-Escalation Antiplatelet Therapy in Patients With Acute Ischemic Stroke
This multicenter, prospective, open-label, randomized controlled trial will evaluate whether platelet aggregation function-guided de-escalation of antiplatelet therapy is non-inferior in efficacy and superior in safety compared…
- Trial name
- PATH STROKE D (NCT07644234)
- Testing
- Clopidogrel, Aspirin
- Where
- China
- Volunteers
- 3,836 people
- Sponsor
- Sichuan Provincial People's Hospital
Insulin Resistance
Insulin Resistance in Adolescents
The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades.
- Trial name
- NCT04089332
- Testing
- Oral Glucose Tolerance Test (OGTT), 3 Tesla MRI, Intravenous Catheter
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Quadraplegia
Robust Intelligent Keyboard for Quadraplegic Patients
This is multi-center prospective randomized trial evaluating the effectiveness of a new brain-computer interface for communication of quadriplegic patients in a clinical context.
- Trial name
- PVCRoBIK (NCT01707498)
- Testing
- Scanning device, RoBIK Brain-Computer Interface
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
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