Clinical trials: Cerebral Hypoperfusion
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Carotid Stenosis
Diabetes and Risk of Ischemic Stroke.
Diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics.
- Trial name
- NCT06401902
- Testing
- carotid clamping
- Where
- France
- Volunteers
- 3,739 people
- Sponsor
- Institut Mutualiste Montsouris
Metabolic Syndrome X
Mechanisms of Cerebrovascular Control
The objective of this study is to identify insulin-specific cerebral blood flow (CBF) control mechanisms, and establish cerebrovascular responsive baseline in younger (18-45 yrs) metabolic syndrome adults (MetSyn) who are at…
- Trial name
- NCT02936687
- Testing
- NOS Inhibition, ET-1 Inhibition, 3 Tesla MRI
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hypoperfusion in Newborn With Congenital Heart Disease
Cerebral Blood Flow in Neonates During Major Cardiac Surgery.
Rationale: During cardiac surgery, neonates are at high risk of cerebral damage: 36-78% will have new cerebral lesions after surgery.
- Trial name
- FLOWER (NCT04713605)
- Testing
- Critical closing pressure detection
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Brain Hypoperfusion Syndrome, Ischemia Brain
Efficiency Study of Siwu Tang to Treat Brain Hypoperfusion Syndrome
Brain hypoperfusion patients may cause vascular dementia results from their hypoperfusion state except that is a risk factor for stroke.
- Trial name
- NCT01221662
- Testing
- Siwu Tang
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Germline Mutation in the NOTCH 3 Gene, Cardiovascular Disease
CADASIL Disease Discovery
Cerebral autosomal dominant arteriopathy with subcortical infarct (CADASIL) is a lethal disease caused by a gene mutation that affects arteries in the brain. Symptoms include migraines, strokes, memory loss, and dementia.
- Conditions
- Germline Mutation in the NOTCH 3 Gene, Cardiovascular Disease, Arterial Stiffness, Pathogenesis of CADASIL
- Trial name
- NCT02821780
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Premedication, Endotracheal Intubation
Cerebral NIRS Profiles During Premedication for Neonatal Intubation
Observational ancillary study of the PRETTINEO study (ClinicalTrials.gov Identifier: NCT01490580) which is a multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil"…
- Conditions
- Premedication, Endotracheal Intubation, Cerebral Hypoperfusion
- Trial name
- NCT02700893
- Testing
- atropine+ propofol, atropine + atracurium + sufentanil
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial
Chemical and Mechanical Angioplasty for Vasospasm (SAVEBRAIN)
This is a monocentric randomized prospective trial comparing 2 different endovascular strategies of intracranial arterial angioplasty in case of refractory intracranial arterial vasospastic stenosis : chemical angioplasty…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial, Stenosis, Ruptured Cerebral Aneurysm
- Trial name
- SAVEBRAIN (NCT05268445)
- Testing
- Chemical and Mechanical Angioplasty for Refractory Intracranial Arterial Vasospastic Stenosis
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Erasme University Hospital
Identify the Presence of a Marker of Ischemia/Hypoperfusion of the Brain Via Peripheral Blood, Ischemia/Hypoperfusion of Brain
Biomarkers of Ischemia: Xanthine, Hypoxanthine and Inosine Levels During Carotid Stenting Procedures
The purpose of the study is to determine if a new blood test can help the doctor determine if there is brain injury or ischemia. Ischemia occurs when not enough oxygen gets to the brain.
- Trial name
- NCT01639534
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Carotid Stenosis, Hypoperfusion
Physiological Magnetic Resonance Imaging (MRI) to Improve Carotid Endarterectomy Outcomes
The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque.
- Conditions
- Carotid Stenosis, Hypoperfusion, Transient Ischemic Attack
- Trial name
- NCT01272843
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sunnybrook Health Sciences Centre
Traumatic Brain Injury
Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury
Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used…
- Trial name
- NCT05616910
- Testing
- inhaled nitric oxide
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Pennsylvania
Multiple Sclerosis, Relapse
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
This is a multi-center, prospective, controlled study. MS patients (1° group: 30 patients in relapse; 2° group: 30 patients in remission) and age/sex-matched healthy controls (3° group: 30 subjects) will be enrolled in the study.
- Trial name
- NCT04380220
- Testing
- Blood samples and processing
- Where
- 3 sites in United States, Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Multiple Sclerosis
Transcranial Electrical Stimulation in Multiple Sclerosis
First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? The blood flow of the subjects is imaged by use of a special MRI-technique.
- Trial name
- TEMS (NCT06966128)
- Testing
- transcranial Direct Current Stimulation
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Acute Ischemic Stroke
Protective Effects of Edaravone Dexborneol
The patients of acute ischemic stroke were divided into two groups, edaravone dexborneol treatment group and edaravone treatment group.
- Trial name
- NCT05024526
- Testing
- edaravone dexborneol or edaravone
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lili Cao
Depression, Hypertension
Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression
This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and…
- Trial name
- NCT01794455
- Testing
- Sertraline, Candesartan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University
Chronic Cerebral Hypoperfusion
Exploratory Study of Intermittent Hypoxia Treatment in Chronic Cerebral Hypoperfusion
This study aims to investigate the safety and efficacy of intermittent hypoxia treatment in patients with chronic cerebral hypoperfusion.
- Trial name
- NCT05824104
- Testing
- Intermittent Hypoxia
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Cardiac Arrest
Augmented Multimodal Neurologic Monitoring in High Risk Survivors of Cardiac Arrest
Cardiac arrest is the most common cause of death in the United States and as many as 590,000 Americans suffering a cardiac arrest each year.
- Trial name
- NCT02069353
- Testing
- QFlow 500™ Perfusion Probe (Hemedex, Cambridge, MA), Spencer Probe Depth Electrode (Ad-Tech Medical, Racine, WI)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jonathan Elmer
Brain Hypoperfusion
Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection as Adjunctive Therapy in Subjects With Internal Carotid Artery Hypoperfusion
The aim of this study is to evaluate the effectiveness, safety and tolerability of consistent dosages of the study drug (hydroxyethyl starch 130/0.4 and sodium chloride injection, Vuloven) administrated intravenously for 7 days.
- Trial name
- NCT01192581
- Testing
- hydroxyethyl starch 130/0.4 and sodium chloride injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Cerebral Hypoperfusion, Hypotension
The Effect of Controlled Hypotension
Controlled hypotension is currently used in spinal surgery to reduce bleeding at the surgical site, improve the surgeon's visibility, and decrease intraoperative blood loss.
- Trial name
- NIRS (NCT06928870)
- Testing
- MAP 55-65 mmHg, MAP 66-75 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital