Clinical trials: Cerebral Infarct
Aneurysmal Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
Satralizumab in Aneurysmal Subarachnoid Hemorrhage
In this study, satralizumab will be administered to see whether satralizumab is safe in patients with a burst brain aneurysm and if it may prevent strokes in patients with a burst brain aneurysm.
- Trial name
- SASH (NCT05727657)
- Testing
- Satralizumab
- Where
- United States
- Sponsor
- University of Florida
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Normobaric Oxygen, Cerebral Ischemia
The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia
Chronic cerebral ischemia (CCI) is viewed as an alarming state induced by long-term reduction in cerebral perfusion, which is associated with neurological deficits and high risk of stroke occurrence or recurrence.
- Trial name
- NCT03745092
- Testing
- normobaric oxygen, room air
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Capital Medical University
Stroke, Cerebral Infarction
Aspirin Or Warfarin To Prevent Stroke
The purpose of this study is to determine whether aspirin or warfarin is more effective in preventing stroke in patients with intracranial stenosis.
- Conditions
- Stroke, Cerebral Infarction, Atherosclerosis, Constriction, Pathologic
- Trial name
- NCT00004728
- Testing
- Warfarin, Aspirin
- Where
- United States
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Stroke, MCA Infarction
Osmotic Agent Use in Middle Cerebral Artery Stroke
This is a retrospective chart review of patients that were admitted with large MCA stroke to the Fairview system hospitals between December 2017-December 2018.
- Trial name
- OMCAS (NCT04156490)
- Testing
- No intervention is planned, this will be a purely retrospective trial.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Ischemic Stroke
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval
The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset.
- Trial name
- NCT03494920
- Testing
- Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR
- Where
- 33 sites in Australia, China and 2 more
- Volunteers
- 295 people
- Sponsor
- Neuroscience Trials Australia
Coronary Artery Disease, Myocardial Infarction
WENBIT - Western Norway B Vitamin Intervention Trial
PURPOSE OF STUDY Observational studies have demonstrated that elevated levels of plasma total homocysteine is a risk factor for cardiovascular disease.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- WENBIT (NCT00354081)
- Testing
- folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine), folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine)
- Where
- 2 sites in Norway
- Volunteers
- 3,096 people
- Sponsor
- Haukeland University Hospital
Cerebral Infarction
Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2)
The purpose of this study is to investigate the efficacy of cilostazol in preventing recurrence of cerebral infarction and the safety of long-term administration of the drug (100 mg, twice daily) in patients with cerebral…
- Trial name
- NCT00234065
- Testing
- Cilostazol, Aspirin
- Where
- Japan
- Volunteers
- 2,800 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Cerebral Infarction
REmote iSchemic Conditioning in acUtE BRAin INfarction Study
Cerebral infarction is the most common form of stroke (80% of strokes). Stroke is the first cause of acquired disability, and the 2nd cause of dementia and death.
- Trial name
- RESCUE-BRAIN (NCT02189928)
- Testing
- Lower limb tourniquet, Usual care
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- Versailles Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Acute, Middle Cerebral Artery Stroke
Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke
The primary objective of the study is to assess the safety and tolerability of Human Placenta-Derived Cells (PDA001) at 3 different dose levels versus placebo (vehicle control) administered intravenously in subjects following…
- Conditions
- Stroke, Acute, Middle Cerebral Artery Stroke, Posterior Cerebral Artery Stroke
- Trial name
- NCT01310114
- Testing
- Human Placenta-Derived Cells PDA001- (cenplacel-L)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Celularity Incorporated
Acute Ischemic Stroke, Stroke
A Reduction in Time With Electronic Monitoring In Stroke
The purpose of the ARTEMIS trial is to investigate if real-time feedback to caregivers reduces the time between patient's first medical contact and start of intravenous thrombolysis and/or intraarterial thrombectomy in patients…
- Trial name
- ARTEMIS (NCT02808806)
- Testing
- real-time audio-visual feedback
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Leiden University
Aortic Valve Disease, Myocardial Infarction
Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial
The purpose of this study is to compare aspirin + clopidogrel with aspirin alone as antithrombotic treatment following transcatheter aortic valve implantation (TAVI) for the prevention of major ischemic events [myocardial…
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke
- Trial name
- ARTE (NCT01559298)
- Testing
- Aspirin (80 mg/d) + clopidogrel (75 mg/d), Aspirin
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Ischemic Cerebral Infarction
Use of Hydrogen Sulphide Donor (N-acetyl Cysteine) in Cases With Acute Ischemic Stroke
1. Clarify novel systemic and local inflammatory mechanisms underlying the cross talk between brain and heart ischemic states, 2.
- Trial name
- NAC - H2S (NCT07749287)
- Testing
- N Acetyl cysteine 600mg, Normal (0.9%) saline
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Helwan University
Ischemia
Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage
The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI.
- Trial name
- NCT02829398
- Testing
- CerebroSpinal fluid and plasma samples
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Toulouse
Acute Ischemic Stroke, Partial Anterior Circulation Infarct
DLBS1033 for Acute Ischemic Stroke Patients
This is a prospective, randomized, double-blind, and controlled clinical study to investigate the effects of DLBS1033 in conjunction with standard therapy compared to standard therapy alone in acute ischemic stroke patients.
- Conditions
- Acute Ischemic Stroke, Partial Anterior Circulation Infarct, Lacunar Anterior Circulation Infarct
- Trial name
- ADDLIST (NCT02133521)
- Testing
- DLBS1033
- Where
- 10 sites in Indonesia
- Volunteers
- 80 people
- Sponsor
- Dexa Medica Group
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅰ (NCT06901466)
- Testing
- Experimental: Rivaroxaban monotherapy, Active Comparator: Rivaroxaban+Clopidogrel
- Where
- China
- Volunteers
- 880 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertension, Dementia
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
High blood pressure (present in 1 of 5 Canadian adults) increases the risk of heart attack and stroke. Blood pressure lowering pills reduce this risk - but perhaps not optimally.
- Trial name
- NCT04054648
- Testing
- Bedtime administration of the participant's pre-existing antihypertensive medications
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of Alberta
High Resolution Vessel Wall Imaging, Recurrent Stroke
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis.
- Conditions
- High Resolution Vessel Wall Imaging, Recurrent Stroke, Stroke, Mechanism, Atheroscleroses, Intracranial
- Trial name
- NCT06404242
- Where
- Vietnam
- Volunteers
- 75 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
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