Clinical trials: Cerebral Microvascular Circulation
Cerebral Small Vessel Diseases, Ischemic Stroke
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in…
- Trial name
- MODEST (NCT06077305)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Cushing Syndrome, Hypercortisolism
Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
- Trial name
- NCT04433819
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marmara University
Aneurysmal Subarachnoid Haemorrhage
Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Dynamic 18F-FDG PET/CT
A pilot trial for assessing early microvascular alterations after aneurysmal subarachnoid hemorrhage using dynamic 18F-FDG PET/CT.
- Trial name
- PREDISP (NCT04356599)
- Testing
- Early dynamic 18F-FDG PET/CT assessment of cerebral glucose uptake
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Stroke, Ischemic
Microcirculation and Plasticity After Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours…
- Trial name
- IMPreST (NCT04035746)
- Testing
- Observation of microcirculation and plasticity of the brain
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Cardiac Arrest, Brain Injuries
Functional MRI to Assess Brain Damage in Cardiac Arrest Patients
This is a single-center, observational study. Patients after successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management.
- Trial name
- NCT05966389
- Testing
- No interventions
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Capital Medical University
Brain Death
Alterations of Conjunctival Microcirculation in Brain Dead Patients
Study hypothesize that ocular microcirculation is reflecting cerebral perfusion. The purpose of this study is to evaluate ocular microcirculation in brain dead patients using side dark field (SDF) videomicroscope and compare it…
- Trial name
- NCT02483273
- Where
- Lithuania
- Volunteers
- 22 people
- Sponsor
- Lithuanian University of Health Sciences
Stroke, Vascular Diseases
Passive Limb Movement Study
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance.
- Conditions
- Stroke, Vascular Diseases, Ischemic
- Trial name
- PLM (NCT05935670)
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
OCTA, Severe Brain Injury
Effect of the Stellate Ganglion Block on the Retinal Microcirculation
Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke.
- Conditions
- OCTA, Severe Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT06797752
- Testing
- OCTA Scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Shock, Microcirculation
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
Alterations in the brain microcirculation may be involved in patients with shock. For a three-day period, we investigate the brain microcirculation using contrast-enhanced ultrasound with microbubble injection in patients with…
- Trial name
- NCT04290767
- Testing
- Sulphur hexafluoride microbubbles SONOVUE (BRACCO, Milan, Italy)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Acute Ischemic Stroke, Reperfusion
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion
- Trial name
- CRYSTAL (NCT05836766)
- Testing
- Y-6 sublingual tablets
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke
Measuring Absolute Brain Flow and Brain Microcirculation Resistance by Continuous Thermodilution
Worldwide, cerebrovascular accidents (also known as strokes) are the leading cause of acquired disability, the second-leading cause of dementia (after Alzheimer's disease) and the second-leading cause of death (but the leading…
- Trial name
- RESISTANCE (NCT07566598)
- Testing
- Measuring Absolute Cerebral Flow and Microvascular Resistance by Thermodilution
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Brain Injury
Macro- and Microcirculation Crosstalk in Brain-damaged Patients Under Anesthesia or in Intensive Care
In patients with severe brain injury, maintenance and control of blood pressure is at the very first point in the management strategy, whether in anesthesia or in intensive care.
- Trial name
- MICRONOR (NCT05285514)
- Testing
- Comparison of macro- and microcirculatory parameters
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Tumors
A Comparison of the Effect of 1.5 Versus 3% NaCl on Brain Relaxation and Microcirculation
Hyperosmotic solutions of 1.5% and 3% NaCl are equally effective for brain relaxation and microcirculation during brain surgery. The effect of 1.5% NaCl on postoperative natremia and natriuresis is less pronounced.
- Trial name
- NCT02537106
- Testing
- 1.5% NaCl, 3% NaCl
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Microcirculation, Coronary Artery Disease
The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
Ischaemic heart disease (IHD) and degenerative brain disease are two major sources of death and disability affecting all countries.
- Conditions
- Microcirculation, Coronary Artery Disease, Cerebrovascular Circulation
- Trial name
- CCMD (NCT06368635)
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Weijing Wang
Sickle Cell Disease
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling…
- Trial name
- DREAM² (NCT02909283)
- Testing
- Physical exams and blood analyzes
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Imagine Institute
Heart Failure With Reduced Ejection Fraction
Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
Cognitive impairment (CI) is highly prevalent in patients with heart failure with reduced ejection fraction (HFrEF), which has significant implications for disease management, quality of life and clinical outcomes.
- Trial name
- LYRIC-HF (NCT07695090)
- Testing
- Lumacaftor 200 MG
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Qanatpharma AG
Carotid Artery Plaque, Aortic Aneurysm
Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS
the aim of this study is to determine whether an intraoperative optimization protocol using the enhanced flow-based hemodynamic parameters of the FloTrac/Vigileo device in combination with intraoperative measurement of the…
- Conditions
- Carotid Artery Plaque, Aortic Aneurysm, Aneurysm
- Trial name
- NCT04913493
- Testing
- Cytocam-IDF
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitair Ziekenhuis Brussel