Clinical trials: Cerebral Perfusion Pressure
Intracranial Pressure Increase, Cerebral Edema
Noninvasive Monitoring of Cerebral Blood Flow Autoregulation
Rheoencephalography (REG) shows promise as a method for noninvasive neuromonitoring, because it reflects cerebrovascular reactivity. This protocol will study clinical and technical conditions required to use REG.
- Trial name
- NCT05170295
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ochsner Health System
Parkinson Disease, Orthostatic Hypotension
Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Abnormalities in the regulation of cardiovascular system due to autonomic nervous system (ANS) dysfunction may lead to a sudden decline in blood pressure (BP) upon standing, sitting or performing activities/exercises in patients…
- Trial name
- NCT03343574
- Testing
- Abdominal Strengthening Exercise
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Faizan Ahmed
General Anesthesia
Cerebral Perfusion Variation During Blood Pressure Changes Under General Anesthesia
The risk associated with arterial hypotension during general anesthesia for surgery has been demonstrated , but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of…
- Trial name
- DELTAPAMAG (NCT05803876)
- Testing
- Diagnostic test - monitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endotracheal Intubation, Continuous IV Sedation
Cerebral Perfusion Pressure Using Precedex and Other Sedatives
The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.
- Conditions
- Endotracheal Intubation, Continuous IV Sedation, ICP Monitoring
- Trial name
- C3PO (NCT01169467)
- Testing
- Standard-of-Care plus Dexmedetomidine, Standard-of-Care
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Duke University
The Time for Determine CPPopt
NIRS Directed Optimal Cerebral Perfusion Pressure in Aneurysmal Subarachnoid Hemorrhage Patients: A Feasibility Study
Neurologic dysfunction is common in aneurysmal subarachnoid hemorrhage (aSAH) patients. As we know, after the initial injury, secondary insults including poor cerebral perfusion are main contributors to poor outcome and their…
- Trial name
- NCT03879330
- Testing
- NIRS monitoring
- Volunteers
- 30 people
- Sponsor
- Xiangya Hospital of Central South University
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Cerebral Perfusion Pressure, Vasopressor Agents
Physiologic Study of Cerebral Perfusion
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
- Conditions
- Cerebral Perfusion Pressure, Vasopressor Agents, Shock, Magnetic Resonance Imaging (MRI), Functional
- Trial name
- NCT02744625
- Testing
- Higher doses of vasopressor therapy for a MAP of 75 mmHg, Lower doses of vasopressor therapy for a MAP of 65 mmHg, Propofol for light sedation
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Intracerebral Hemorrhage, Critically Ill
Early Multimodal Neuromonitoring For Spontaneous Intracerebral Hemorrhage (ICH)
The investigators intend to assess the predictive value of early (first 48 hours) multimodal neuromonitoring parameters concerning late survival in critically ill intracerebral hemorrhage (ICH) patients.
- Conditions
- Intracerebral Hemorrhage, Critically Ill, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- NCT05501613
- Testing
- Multimodal Neuromonitoring
- Where
- Portugal
- Volunteers
- 65 people
- Sponsor
- Universidade do Porto
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Intracranial Pressure, Circulation System
The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood.
- Conditions
- Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
- Trial name
- TILTDOWN-3 (NCT06865027)
- Testing
- Ventilation strategy
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University Hospital, Akershus
Subdural Pressure During Supratentorial Brain Tumour Resection
Neurosurgery Recruitment Maneuver Study
Background. Patients undergoing neurosurgical procedures experience higher rates of postoperative respiratory failure compared to the broader surgical population.
- Trial name
- NCT02093117
- Testing
- Recruitment maneuver
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Cerebral Perfusion Pressure, Trendelenburg
Transcranial Doppler and NIRS Monitoring of Cerebral Hemodynamics in Pediatric Laparoscopic Surgery
Laparoscopic surgery has become increasingly common in pediatric patients due to its minimally invasive nature and favorable postoperative outcomes.
- Conditions
- Cerebral Perfusion Pressure, Trendelenburg, Pediatric
- Trial name
- NCT07482514
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hanife Kabukcu
Intracranial Hypertension
Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery
This prospective study aims to compare the effects of minimal invasive extracorporeal circulation (MiECC) and conventional reservoir-based extracorporeal circulation techniques on cerebral perfusion in patients undergoing…
- Trial name
- NCT07420738
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kartal Kosuyolu High Speciality Training and Research Hospital
Cognitively Normal Older Adults, Hypertension
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
- Trial name
- IPAT (NCT05331144)
- Testing
- Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Rong Zhang
Traumatic Brain Injury, Severe Traumatic Brain Injury
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- Cogitate II (NCT07287358)
- Testing
- Optimal cerebral perfusion pressure
- Where
- 4 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury
Early Propranolol After Traumatic Brain Injury: Phase II
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol.
- Trial name
- EPAT: Phase II (NCT01202110)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Cerebral Hypoperfusion
Real-Time Decision Support for Improving Intraoperative Cerebral Perfusion Pressure
Across broad surgical populations, cerebral hypoperfusion is associated with increased mortality, stroke, brain cellular injury, and poor functional outcomes.
- Trial name
- NCT03285971
- Testing
- Electronic CPP pager alert
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Michigan
Intracerebral Hemorrhage
Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial
Rationale: Management of blood pressure (BP) in the acute phase of intracerebral hemorrhage (ICH) remains controversial. Although it has been established that there is a transient moderate reduction of perihematoma cerebral blood…
- Trial name
- ICH ADAPT (NCT00963976)
- Testing
- labetalol/hydralazine/enalapril
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Cerebral Blood Flow, Cerebral Perfusion Pressure
Continous Assessment of Cerebral Autoregulation With Near-infrared Spectroscopy
Cerebral autoregulation can be explained by a tight coupling between oxygen supply and demand of the brain, and is essential to maintain a constant cerebral blood flow (CBF) in the context of changes in cerebral perfusion…
- Trial name
- NCT02959008
- Testing
- measure TOI and BP
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yu Liyun
Glaucoma
Blood Flow of Ophthalmic Artery and Glaucoma
The main purpose of this project is to investigate the blood flow of the ophthalmic artery (OA) in patients with ocular hypertension, high tension glaucoma and normal tension glaucoma.
- Trial name
- NCT02656979
- Testing
- Latanoprost
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Umeå University