Clinical trials: Cerebral Perfusion Pressure
Brain Lesion
Effect of the Position of the Patient's Head
The position of the head of the patient influences the cerebral venous return and cerebral perfusion pressure (CPP). In our daily practice, it is almost routine to prescribe a Trendelenburg position 30 ° in all brain-damaged…
- Trial name
- NCT02549313
- Testing
- position changes of the head
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Lumbar Disc Disease, Lumbar Spinal Stenosis
The Effects of Anesthesia on Cerebral Perfusion in Patients With High Blood Pressure
High blood pressure is a serious and common health problem. This disease affects 1 billion people all over the world and responsible for 7,1 million deaths.
- Conditions
- Lumbar Disc Disease, Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Fracture
- Trial name
- NCT04587401
- Testing
- normotensive patients, patients with hypertension diagnosis, patients who do not know they are hypertensive but actual blood pressure is high
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Cerebral Hemorrhage, Subarachnoid Hemorrhage
Brain PERfusion Evaluation by Contrast-Enhanced UltraSound
The objective of the study is to assess brain tissue perfusion by contrast-enhanced ultrasound perfusion imaging (PerCEUS) in acute brain injuries.
- Conditions
- Cerebral Hemorrhage, Subarachnoid Hemorrhage, Ischemic Stroke, Cerebrovascular Circulation
- Trial name
- PerCEUS (NCT05893407)
- Testing
- Measuring contrast-enhanced ultrasound perfusion with phase inversion harmonic imaging
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Perfusion
Comparative Analysis of Cerebral Oximetry and Mean Arterial Pressures at the Cerebral Level in the Beach Chair Position
The purpose of this study is to compare the changes measured by Somanetics Invos cerebral oximeter to the mean arterial pressure at brain level in patients having elective shoulder replacement surgery.
- Trial name
- NCT01645982
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Paul Papagni
Trauma, Brain, Hemorrhage Cerebral
Research of Optimal Cerebral Perfusion Pressure Diagnosis
The research will investigate the hypothesis that timely identification of the optimal value of the cerebral perfusion pressure (optCPP) or optimal arterial blood pressure (optABP) is possible after detecting informative episodes…
- Trial name
- optCPP (NCT06028906)
- Testing
- Multimodal physiological monitoring and cerebral autoregulation monitoring
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Vilnius University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Normothermia in Patients With Acute Cerebral Damage
The purpose of our study is to verify wherever normothermia (achieved with diclofenac administration) may improve intracranial pressure control and may limit secondary cerebral damage thus positively influencing outcome in…
- Trial name
- NCT00491192
- Testing
- Diclofenac
- Where
- Italy
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypertension, Stroke
Cilnidipine Effect on High Blood Pressure and Cerebral Perfusion in Ischemic Stroke Patients With Hypertension
The purpose of this study is to compare the effect of cilnidipine (a calcium channel blocker) and losartan (an angiotensin II receptor blocker) on cerebral blood flow (CBF) and blood pressure in hypertensive patients with a…
- Trial name
- NCT00325637
- Testing
- cilnidipine
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Stroke, Hemorrhage
Positive and Expiratory Pressure and Hemorrhagic Stroke
Intrathoracic positive pressure may lead to a change hemodynamics, with repercussions for the intracranial compartment, thereby altering intracranial pressure (ICP) and cerebral perfusion pressure (CPP).
- Trial name
- NCT01109355
- Testing
- lung mechanics ventilatory, Hemodynamic and intracranial pressure
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal de Pernambuco
Stroke
The Acute and Chronic Effects of a Heel Raise Programme on Central Blood Pressure, Arterial Compliance and Oxygen Perfusion After Stroke
Physical inactivity and increased sedentary time are linked to increased blood pressure and may cause decreases in peripheral and cerebral oxygen perfusion in stroke survivors.
- Trial name
- NCT03423433
- Testing
- Heel raise intervention
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Winchester
Intra-operative Hypotension, Carotid Stenosis
Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Carotid endarterectomy (CEA) is the recommended treatment for symptomatic high degree stenosis of the internal carotid artery (ICA).
- Trial name
- NCT01451294
- Testing
- Administration of phenylephrine, Administration of ephedrine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- G.J. de Borst
Intracranial Hypertension
Intracranial Pressure and Brain Function: Effects of Head Down Tilt Upon Brain Perfusion and Cognitive Performance
The aim of the study is to understand the relationship between intracranial pressure regulation, cerebral tissue oxygenation and cognitive functioning.
- Trial name
- IPCog (NCT02976168)
- Testing
- 12° head down tilt
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Brain Injuries, Subarachnoid Hemorrhage
A Study Comparing Modified Lund Concept and Cerebral Perfusion Pressure-targeted Therapy in Secondary Brain Ischaemia.
Secondary brain ischaemia (SBI) usually develops after aneurysmal subarachnoid haemorrhage (SAH) and severe traumatic brain injury (TBI).
- Trial name
- NCT01206283
- Testing
- Modified Lund concept, Cerebral perfusion pressure-targeted therapy
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- University of Sarajevo
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington
Increase in Intra-abdominal Pressure, Increase in Intracranial Pressure (ICP)
Changes in Cerebral Oxygenation Studies During Laparoscopy Procedure
The motivation results from the fact, that an intra-abdominal pressure is correlated with cerebral perfusion, in a mechanism of reducing venous outflow.
- Conditions
- Increase in Intra-abdominal Pressure, Increase in Intracranial Pressure (ICP), Laparoscopy, Cerebral Perfusion and Oxygenation
- Trial name
- NCT03640741
- Testing
- Laparoscopy
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
Intracranial Pressure, Critical Care
JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion
Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse.
- Trial name
- JUGULATE (NCT07665606)
- Testing
- Ultrasound assessment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Intracranial Pressure, Cerebral Blood Flows
Combined Flow and Pressure Study of Craniospinal Dynamic
Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible.
- Conditions
- Intracranial Pressure, Cerebral Blood Flows, Infusion Test, Phase Contrast MRI
- Trial name
- REVERT (NCT05068128)
- Testing
- Flow MRI, PERFUSION TEST
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cardiac Arrest
Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients
The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest.
- Trial name
- NCT00951704
- Where
- 2 sites in Finland
- Volunteers
- 1,000 people
- Sponsor
- Tampere University Hospital