Clinical trials: Cerebral Small Vessels Disease
Fabry Disease
Canadian Fabry Disease Initiative (CFDI) National Registry
CFDI NATIONAL REGISTRY Fabry disease is a rare, inherited, genetic condition due to a deficiency of an enzyme called alpha-galactosidase A.
- Trial name
- CFDI-NR (NCT00455104)
- Testing
- No intervention
- Where
- 5 sites in Canada
- Volunteers
- 600 people
- Sponsor
- Canadian Fabry Research Consortium
Fabry Disease
French Prospective, Observational Cohort Study of Patients With Fabry Disease Treated With Migalastat
This is a noninterventional cohort study to evaluate the effects of migalastat, on long-term safety, effectiveness, and quality of life (QOL) in patients with Fabry disease.
- Trial name
- NCT04602364
- Testing
- Noninterventional
- Where
- 13 sites in France
- Volunteers
- 48 people
- Sponsor
- Amicus Therapeutics France SAS
Small Vessel Cerebrovascular Disease
Oxford Haemodynamic Adaptation to Reduce Pulsatility Trial
Chronic damage to small blood vessels deep in the brain is seen in half of patients over the age of 60 and almost all patients over the age of 80, and is responsible for up to a third of strokes and almost half of patients with…
- Trial name
- OxHARP (NCT03855332)
- Testing
- Sildenafil, Cilostazol
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Oxford
Dementia, Cardiovascular Risk Factor
Cerebrovascular Correlates of Dementia in Rural Communities - The Three Villages Study
This study aims to assess the prevalence and severity of dementia in an established cohort of community-dwelling older adults living in three neighboring rural Ecuadorian villages (Atahualpa, El Tambo, and Prosperidad), as well…
- Conditions
- Dementia, Cardiovascular Risk Factor, Atherosclerosis, Cerebral Small Vessel Diseases
- Trial name
- NCT04123171
- Testing
- Neuroimaging studies
- Where
- 2 sites in Ecuador
- Volunteers
- 600 people
- Sponsor
- Universidad de Especialidades Espiritu Santo
Fabry Disease
Registry of Fabry Disease - A Multicenter Observational Study
The purpose of this study is to compile a registry of patients with Fabry disease, an inherited metabolic disorder. In this disease, an enzyme called a-galactosidase A, which normally breaks down a lipid (fatty substance) called…
- Trial name
- NCT00055016
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy
Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes
The objective of our study is to investigate the association of umbilical cord abnormalities with adverse pregnancy outcomes. The umbilical cord parameters that will be investigated as part of this study include the umbilical…
- Conditions
- Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy, Stillbirth, Admission to Neonatal Unit
- Trial name
- ULOOP (NCT05901688)
- Testing
- Umbilical cord measurements & observations
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Medway NHS Foundation Trust
Cerebral Small Vessel Diseases, Postmenopausal Symptoms
Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI
The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI.
- Conditions
- Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity
- Trial name
- MIRACLE (NCT05982470)
- Testing
- Estradiol Gel, Progesterone Soft Capsule
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Cerebral Small Vessel Diseases
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study
TRIDENT Main Study: TRIDENT is a multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial of a fixed low-dose combination BP-lowering pill ("Triple Pill") strategy on top of…
- Conditions
- Stroke, Cerebral Small Vessel Diseases, Intracerebral Hemorrhage, Vascular Dementia
- Trial name
- TRIDENT-MRI (NCT03783754)
- Testing
- telmisartan 20 mg + amlodipine 2.5mg + indapamide 1.25mg
- Where
- 3 sites in Australia
- Volunteers
- 4 people
- Sponsor
- The George Institute
Brain Infarction
Cortical Cerebellar Infarctions Associated With Patent Foramen Ovale in Young Stroke Patients
The investigator retrospectively analyzed consecutive young (<60 years) cryptogenic stroke patients with Patient Foramen Ovale (PFO) recruited between January 2016 and May 2019 in our center, and compared these patients with sex…
- Trial name
- NCT04043559
- Testing
- MRI scanner, Contrast transoesophageal echocardiography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Granulomatosis, Wegener's, Microscopic Polyangiitis
Pharmacokinetic Study of Rituximab Induction Regimen in ANCA-associated Vasculitis
The aim of the investigators' study is to evaluate whether monitoring serum rituximab levels could be an interesting tool in the follow-up of ANCA-associated vasculitis patients.
- Trial name
- MONITUX (NCT02474888)
- Testing
- blood specimen
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
MELAS Syndrome, Mitochondrial Diseases
Ketones & Mitochondrial Heteroplasmy
The current study is a prospective evaluation of the ability of ketosis to shift mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known mutation in their mtDNA at position 3243 (A>G).
- Trial name
- NCT01252979
- Testing
- Medium-Chain Triglycerides
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Retina is a Marker for Cerebrovascular Heath
Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression.
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Cerebral Microbleeding, Sporadic White Matter Disease
- Trial name
- NCT04753970
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Fabry Disease
Open-Label Expanded Access Treatment With Pegunigalsidase Alfa for Fabry Disease Patients
The objective of this treatment protocol is to provide guidance to Treating Physicians who seek access to pegunigalsidase alfa for Fabry patients whose clinical condition, in the opinion of the Treating Physician, requires…
- Trial name
- NCT04552691
- Testing
- Pegunigalsidase Alfa
- Where
- 11 sites in United States
- Sponsor
- Chiesi Farmaceutici S.p.A.
Subcortical Vascular Dementia, Cerebral Small Vessel Diseases
The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia
This is a 48-week, double-blind, randomized, placebo-controlled study. Sixty-four patients are randomly assigned to take NBP (600mg per day) or placebo for 48 weeks, with 32 patients in each treatment group.
- Trial name
- NCT03906123
- Testing
- NBP
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tianjin Medical University General Hospital
Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease
Prognosis of Cerebral Small Vessel Disease
Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients…
- Conditions
- Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy
- Trial name
- PRO-SVD (NCT05734378)
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fabry Disease
A Study of REPLAGAL® in Treatment-naive Chinese Participants With Fabry Disease
The main aim of the study is to assess the safety of REPLAGAL. Study participants will receive REPLAGAL as an intravenous infusion every other week for 52 weeks.
- Trial name
- NCT04974749
- Testing
- REPLAGAL
- Where
- 6 sites in China
- Volunteers
- 20 people
- Sponsor
- Takeda
Cerebral Small Vessel Diseases
Recovery Improved in Covert Stroke With Exercise
Silent ischemic, also known as "covert stroke vascular disease" (CSVD), contributes to neurological deficits that are caused by damage to small blood vessels in the brain.
- Trial name
- RISE-2 (NCT02068391)
- Testing
- Stretching Program, Exercise Program
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Intracranial Aneurysm, Unruptured Cerebral Aneurysm
Chinese Small Intracranial Aneurysm Study (CSIAS)
Intracranial aneurysms are common in the general population. The overall prevalence of unruptured intracranial aneurysms (UIAs) is estimated of 2.3-3.2% in the population without specific risk factors for SAH.
- Conditions
- Intracranial Aneurysm, Unruptured Cerebral Aneurysm, Treatment Side Effects
- Trial name
- NCT02948504
- Testing
- Coiling or Clipping
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
CADASIL, Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy
Long-term Prospective Study of Korean CADASIL Patients
K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia.
- Trial name
- K-CADASIL (NCT07497867)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Jeju National University Hospital