Clinical trials: Cerebrovascular Apoplexy
Diabetes Mellitus, Type 2, Stroke (CVA) or Transient Ischemic Attack
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
A human subjects research study, the primary purpose of which is to assess the EFFECTS OF SEMAGLUTIDE ON INTRACRANIAL BLOOD FLOW AND BLOOD-BRAIN BARRIER PERMEABILITY IN TYPE-2 DIABETES (T2D) through testing of the intervention on…
- Trial name
- NCT05780905
- Testing
- Semaglutide Auto-Injector
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Stroke
Enhancing Participation of Chronic Stroke Patients by Constraint Induced Movement Therapy (HOMECIMT)
The aim of this study is to evaluate the efficacy of a modified approach of constraint induced movement therapy ("CIMT at home") for chronic stroke patients, compared to conventional physiotherapy and occupational therapy…
- Trial name
- HOMECIMT (NCT01343602)
- Testing
- mod. Constraint-Induced Movement Therapy, Therapy as usual
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ischemic Stroke
Effect of External Counter Pulsation on Ischemic Stroke
Stroke is a prevalent atherosclerosis vascular disease with high mortality, external counter pulsation (ECP) is an approved noninvasive therapy for angina, congestive heart failure, myocardial infarction, and cardiogenic shock…
- Trial name
- NCT03075137
- Testing
- External counter pulsation (ECP)
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Coronary Arteriosclerosis, Diabetes Mellitus, Type 2
Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)
Physicians tend to always use the lowest dose of statins to initiate therapy even in subjects who require large reductions in cholesterol.
- Conditions
- Coronary Arteriosclerosis, Diabetes Mellitus, Type 2, Cerebrovascular Accident, Dyslipidemia
- Trial name
- ACTFAST (NCT00442845)
- Testing
- Atorvastatin (Lipitor)
- Where
- 121 sites in Cameroon, Canada and 3 more
- Volunteers
- 2,080 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Stroke, Proprioceptive Disorders
Combined Effects of PNF and Electrical Muscle Stimulation on Spasticity and Hand Function in Stroke Patients.
To determine the combined effects of proprioceptive neuromuscular facilitation and electrical muscle stimulation on spasticity and hand function in stroke patients.
- Conditions
- Stroke, Proprioceptive Disorders, Balance; Distorted
- Trial name
- NCT05916872
- Testing
- experimental group, control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Coronary Heart Disease, Stroke
The Copenhagen City Heart Study
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population.
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer
- Trial name
- CCHS (NCT02993172)
- Volunteers
- 23,891 people
- Sponsor
- Bispebjerg Hospital
Acute Ischemic Stroke (AIS), Pediatric Stroke
Prospective Registry of Acute Ischemic Stroke in Children Under 18 Years Old in China
This observational study aims to investigate the real-world effectiveness and safety of different treatment strategies for acute ischemic stroke (AIS) in Chinese children under 18 years of age.
- Trial name
- NCT07550257
- Testing
- Standard Clinical Management
- Volunteers
- 1,000 people
- Sponsor
- Gansu Provincial Maternal and Child Health Care Hospital
Stroke, Atrial Fibrillation
Novel Methods for Arrhythmia Detection: Preliminary Study
Approximately 20-25% of strokes are of cardioembolic origin, atrial fibrillation (AF) being a significant cause of cardioembolic strokes. AF is often symptomless and intermittent, making its detection a clinical challenge.
- Trial name
- NCT03721601
- Testing
- Heart rate monitor chest strap, Wrist band photoplethysmography
- Where
- 3 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Kuopio University Hospital
Stroke
Using 5 Minute Videos for Numeracy and Literacy Challenged Stroke Survivors to Improve Outcomes
Two thirds of all strokes happen in developing countries like Pakistan. There is a serious lack of health literacy regarding survival after stroke.
- Trial name
- NCT02202330
- Testing
- Video Arm
- Where
- Pakistan
- Volunteers
- 310 people
- Sponsor
- Aga Khan University
Decompressive Craniectomy, Brain Injuries
Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage…
- Conditions
- Decompressive Craniectomy, Brain Injuries, Treatment Outcome
- Trial name
- NCT04682951
- Testing
- Decompressive Craniectomy
- Where
- France
- Volunteers
- 544 people
- Sponsor
- Central Hospital, Nancy, France
Stroke
LUNA-EMG to Enhance Motor Functions in Neurological Disorders
The aim of the present study is to evaluate the effects of training performed with the LUNA-EMG system to enhance motor functions of the upper limb in stroke This is a randomized open-label trial.
- Trial name
- LUNA (NCT04716829)
- Testing
- LUNA-EMG
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- University of Liege
Acute Stroke
The Prevalence and Associated Factors of Early Deterioration After Successful Recanalization in Acute Ischemic Stroke
stroke is a leading cause of morbidity and mortality worldwide. More than half (54.5%) of the 56.9 million deaths worldwide in 2106 were due to the top 10 causes.
- Trial name
- NCT04978181
- Testing
- Alteplase Injection
- Volunteers
- 30 people
- Sponsor
- Assiut University
Stroke, Ischemic, Transient Ischemic Attack
Liverpool-Heart and BRain Project Stroke Cohort
What research question is being addressed? Can improve the prediction of adverse outcomes be improved for people following a stroke to optimise their treatment and care? How is it of relevance and importance to patients and…
- Trial name
- L-HARP (NCT05132465)
- Where
- United Kingdom
- Volunteers
- 1,655 people
- Sponsor
- University of Liverpool
Acute Ischemic Stroke and Transient Ischemic Attacks
Computer Scan Based Analysing System on Improving Stroke Management Quality Evaluation
Study is designed for two parts, a perspective, multi-center, historial control study and a randomized controlled study of acute ischemic stroke patients.
- Trial name
- CASE (NCT03684629)
- Testing
- the response of KPI and corresponding suggestion
- Where
- China
- Volunteers
- 16,570 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Immersive Virtual Reality in Stroke Pilot Study
Over 15,000 Veterans are treated by the VA for stroke each year. A stroke means that part of the brain dies. Many people who have a stroke have difficulty with moving their arm, using their hand, and they have pain.
- Trial name
- VR (NCT04429945)
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Bleeding Disorder, Ischemic Stroke
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR)…
- Conditions
- Bleeding Disorder, Ischemic Stroke, Hemorrhagic Stroke, Hematological Diseases
- Trial name
- NCT03815175
- Testing
- XIENCE, DAPT (aspirin and/or P2Y12 receptor inhibitor)
- Where
- 111 sites in United States, Austria and 13 more
- Volunteers
- 1,605 people
- Sponsor
- Abbott Medical Devices
Stroke, Hemiparesis
Neuromuscular and Biomechanical Control of Lower Limb Loading in Individuals With Chronic Stroke
Stroke is the leading cause of long-term disability in the U.S. Individuals with hemiparesis due to stroke often have difficulty bearing weight on their legs and transferring weight from one leg to the other.
- Trial name
- NCT03694028
- Testing
- Limb Loading, Conventional Training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Acute Coronary Syndrome
Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes
The McGill University Health Center (MUHC) Division of Cardiology, with funding from the Canadian Institute of Health Research, is performing this randomized controlled trial to determine which dual antiplatelet therapy (DAPT)…
- Trial name
- TC4 (NCT04057300)
- Testing
- Ticagrelor 90mg, Clopidogrel 75mg, acetylsalicylic acid (ASA) 81mg
- Where
- Canada
- Volunteers
- 1,038 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Thromboembolic Events
Association of Genetic Variants With Risk of Stroke in Patients With Atrial Fibrillation Off-anticoagulation
Life-long therapy with oral anticoagulants (OAC) is strongly recommended in AF patients receiving left atrial appendage isolation (LAAI) to prevent thromboembolic (TE) events.
- Trial name
- GSAF (NCT04115436)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Chagas Disease With Heart Failure
Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
The main purpose of the study is to determine noninvasive markers of brain involvement in Chagas disease. In a subgroup of patients with high intensity transient signals (HITS) on transcranial Doppler monitorization, the…
- Trial name
- CLINICS (NCT01650792)
- Testing
- Aspirin
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Federal University of Bahia
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