Clinical trials: Cerebrovascular Apoplexy
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Ischemic Stroke, Hemorrhagic Stroke
Transcranial Direct Current Stimulation, Functional Activity, Stroke, RCT
Stroke patients often experience impaired balance and weight-bearing due to muscle weakness and neurological deficits. Motor rehabilitation is a crucial goal in their recovery, and transcranial direct current stimulation (tDCS)…
- Conditions
- Ischemic Stroke, Hemorrhagic Stroke, Stroke, Cardiovascular
- Trial name
- NCT07200661
- Testing
- Experimental A tDCS: Transcranial direct current stimulation., Experimental B tDCS: Transcranial direct current stimulation., Experimental C tDCS: Transcranial direct current stimulation.
- Where
- 3 sites in Thailand
- Volunteers
- 30 people
- Sponsor
- University of Phayao
Ischemic Stroke
Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals
Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals 1. Study Objectives Primary Objective: To determine the prevalence of LVO among acute ischemic stroke (AIS) patients…
- Trial name
- NCT07326410
- Volunteers
- 300 people
- Sponsor
- Assiut University
Recovery Methods, Rehabilitation Program
A Randomized, Single-blind Trial of LI-TMS and AVS for Stoke Recovery in Healthy Participants (Phase 1).
This randomized, controlled, single-blind clinical pilot study investigates the therapeutic potential of low-intensity repetitive transcranial magnetic stimulation (LI-TMS) and audio-visual stimulation (AVS) and newly offered…
- Conditions
- Recovery Methods, Rehabilitation Program, Stroke, Ischemic, Stroke
- Trial name
- NCT06613282
- Testing
- Low Intensity Transcranial Magnetic Stimulation, Auditory and visual stimulation
- Where
- Russia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Siberian Scientific Research and Test Center for Biomedical Engineering
Cardioembolic Stroke
Dabigatran Study in the Early Phase of Stroke. New Neuroimaging Markers and Biomarkers Study (SEDMAN STUDY)
SEDMAN study is a prospective multicenter investigator initiated study (IIS). The main idea is to look by Genome Wide Association (arrays that determine more than 1 million polymorphisms) genetic risk factors associated with…
- Trial name
- SEDMAN (NCT02742480)
- Testing
- Dabigatran, Acenocoumarol
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Mutua de Terrassa
Stroke, Cerebral Vascular Accident (CVA)/Stroke
Error-enhanced Learning & Recovery in 2 & 3 Dimensions
This study is being done to see how errors lead to improvement. Specifically, we are evaluating the errors stroke participants make during an upper extremity exercise program when reaching for a target using their affected arm.
- Trial name
- NCT05180786
- Testing
- Error Fields, No Error Fields
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Cardiovascular Death
A Prospective Multicenter Study to Evaluate Usefulness of Cardio-Ankle Vascular Index in Japan
The objective of this five-year prospective observational follow-up study is to examine the additional benefits of using cardio-ankle vascular index (CAVI) as a predictive indicator of cardiovascular events in high-risk patients.
- Conditions
- Stroke, Cardiovascular Death, Nonfatal Myocardial Infarction
- Trial name
- CAVI-J (NCT01859897)
- Where
- Japan
- Volunteers
- 3,026 people
- Sponsor
- CAVI-J Study Group
Stroke, Rehabilitation
Virtual Reality-Based Upper Limb Rehabilitation in Chronic Stroke
This randomized controlled study aims to evaluate the effectiveness of non-immersive virtual reality-based rehabilitation using the MindMotion™ GO system compared with conventional occupational therapy for improving upper limb…
- Conditions
- Stroke, Rehabilitation, Upper Limb Paresis, Chronic Stroke Patient
- Trial name
- NCT07534124
- Testing
- Non-Immersive Virtual Reality Rehabilitation, Occupational Therapy
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad Complutense de Madrid
Ischemic Stroke
A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic…
- Trial name
- NCT07291024
- Testing
- Vagus nerve stimulation (VNS) paired with mobility training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Neurologic Disorder, Paralysis
EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis
Neuralis is an innovative assistive technology designed for individuals with severe neuromuscular conditions, enabling wheelchair control through EEG signals.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06169696
- Testing
- Intervention/Treatment
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Synaptrix Labs Inc.
Stroke
Thrombolysis in Pediatric Stroke (TIPS)
Thrombolysis in Pediatric Stroke (TIPS) is a five-year multi-center international safety and dose-finding study of intravenous (IV) tPA in children with acute ischemic stroke (AIS) to determine the maximal safe dose of…
- Trial name
- TIPS (NCT01591096)
- Testing
- Tissue plasminogen activator (Activase®)
- Where
- 15 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Seattle Children's Hospital
Atrial Fibrillation, Atrial Flutter
Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk
The IMPACT Study will investigate the potential clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) technology and a predefined anticoagulation plan compared to conventional device evaluation and…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Stroke, Embolism, Systemic Arterial
- Trial name
- IMPACT (NCT00559988)
- Testing
- Home Monitoring Guided OAC, Physician-Directed OAC
- Where
- 80 sites in United States, Australia and 4 more
- Volunteers
- 2,718 people
- Sponsor
- Biotronik, Inc.
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Stroke
Neurovascular Unit for Aged Patients With Geriatric Care and Evaluation of Factors Associated With Autonomy Loss
There are few neurovascular units (short stay and MRS (medical and rehabilitation service)) dedicated to the care of older people after a stroke in France and around the world.
- Trial name
- NUAGE (NCT07805694)
- Testing
- Not applicable- observational study
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- Hospices Civils de Lyon
Stroke
Peripheral Nerve Stimulation to Improve Upper Extremity Function After Severe Stroke
Subjects will receive non-invasive stimulation of nerves on their arm and intensive motor training of their arm. The timing of the stimulation in relation to the training will vary by group.
- Trial name
- NCT04576013
- Testing
- Peripheral nerve stimulation (PNS), Intensive upper extremity motor training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Kentucky
Intracerebral Hemorrhage, Atrial Fibrillation
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).
- Trial name
- ASPIRE (NCT03907046)
- Testing
- Apixaban, Aspirin
- Where
- 187 sites in United States
- Volunteers
- 700 people
- Sponsor
- Yale University
Ischemic Stroke, Sleep Apnea Syndromes
Pilot-Study for SAS Treatment in Acute Cerebral InfarctiOn: the PISTACIO Trial
Sleep Apnea Syndrome (SAS) is highly prevalent in acute stroke and it is related to worst outcome. We aim to assess if SAS treatment, started immediately after acute ischemic stroke, impacts infarct growing and clinical prognosis.
- Trial name
- PISTACIO (NCT04801069)
- Testing
- Nocturnal Ventilation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- SOS Attaque Cérébrale
Ischemic Stroke
Glyburide Advantage in Malignant Edema and Stroke Pilot
The primary objective of this study is to assess the feasibility of enrolling, evaluating, and treating with glyburide for injection severe anterior circulation ischemic stroke participants, whether or not treated with standard…
- Trial name
- GAMES-PILOT (NCT01268683)
- Testing
- Glyburide for Injection
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Intracerebral Hemorrhage
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.
- Trial name
- NCT00075959
- Testing
- NXY-059
- Where
- 64 sites in United States
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Stroke
Effects of Upper Limb Motor and Robotic Training Over Neuroplasticity and Function Capacity
The purpose of this study is to evaluate and compare the effects of upper limb training with Induced Constraint Therapy (ICT) or robotic therapy. No placebo therapy is used.
- Trial name
- NARLE1 (NCT02700061)
- Testing
- Robotic occupational therapy, Induced Constraint Therapy - ICT
- Where
- Brazil
- Volunteers
- 51 people
- Sponsor
- University of Sao Paulo General Hospital
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