Clinical trials: Cerebrovascular Disease
Stroke
Randomized Trial of Transcranial Theta-burst Stimulation and Transcranial Direct Current Stimulation
Background: Stroke is a leading cause of adult disability. Non-invasive brain stimulation can induce significant and sustained improvements in functional outcome.
- Trial name
- NCT02031107
- Testing
- cTBS, cathodal tDCS
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- Adrian Guggisberg
Stroke, Ischemic, Stroke Hemorrhagic
Clinical Investigation to Evaluate the Suitability of StrokeWave in Distinguishing Haemorragic From Ischaemic Strokes
This is a pilot, monocentric clinical investigation to evaluate the suitability of StrokeWave in distinguishing haemorragic from ischaemic strokes.
- Trial name
- NCT04622644
- Testing
- Device: clinical investigation microwave device class IIa not marked CE for stroke detection
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Umbria Bioengineering Technologies
Rheumatic Heart Disease
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority
This program is a comprehensive evaluation of rheumatic valvular heart disease (RVHD), Atrial fibrillation (AF)/flutter and stroke.
- Trial name
- INVICTUS-VKA (NCT02832544)
- Testing
- Rivaroxaban (20 mg), Vitamin K antagonists (VKA)
- Where
- 139 sites in Botswana, Brazil and 23 more
- Volunteers
- 4,565 people
- Sponsor
- Population Health Research Institute
Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage
MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA
In this three-year proposal, we will explore the MRI-visible EPVS in CAA and investigate its pathophysiology using animal models.
- Trial name
- CAA (NCT04604587)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Stroke
The Effects of Augmented Reality Versus Virtual Reality
This randomized controlled trial aims to compare the effects of augmented reality (AR) and virtual reality (VR)-assisted treadmill gait training on balance and walking in individuals with stroke, within the framework of the…
- Trial name
- NCT07113093
- Testing
- Augmented Reality, Virtual Reality, Self Directed Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara Yildirim Beyazıt University
Fabry Disease, Neuropathic Pain
Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
The purpose of this study is to determine efficacy of gabapentin vs. placebo at controlling peripheral neuropathic pain in patients with Fabry disease, and reducing their use of opioid analgesics.
- Trial name
- NCT01588314
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- University of Minnesota
Stroke
PCMS Task After Moderate-to-severe Stroke
Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke.
- Trial name
- NCT05736653
- Testing
- Task-specific PCMS, PCMS-rest
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Utah
Fatigue, Stroke
Effects of Nutrition on Post Stroke Fatigue
Fatigue, which is commonly defined as a feeling of tiredness during or after usual activities, or a feeling of insufficient energy to initiate these activities, is one of the most common secondary conditions among patients…
- Trial name
- NUTRE-S (NCT05728229)
- Testing
- Supplement with SiderAl® Med
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cerebrovascular Disorder, Stroke
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
Background: A stroke occurs when not enough blood reaches the brain. Sometimes stroke causes changes in certain brain matter. This is called white matter hyperintensity (WMH) and can lead to mental decline.
- Conditions
- Cerebrovascular Disorder, Stroke, Aging
- Trial name
- NCT03366129
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Apathy, Minor Stroke
Non-disabling Ischemic Cerebrovascular Event With Apathy
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. However, few previous studies have focused on affective impairment after transient ischemic attack (TIA) and minor stroke.
- Conditions
- Apathy, Minor Stroke, Transient Ischemic Attack, Stroke
- Trial name
- NCT04917237
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Fabry Disease
Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease
This study aimed to determine the efficacy and safety of lucerastat oral monotherapy in adult subjects with Fabry disease.
- Trial name
- MODIFY (NCT03425539)
- Testing
- Lucerastat
- Where
- 49 sites in United States, Australia and 12 more
- Volunteers
- 118 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Stroke, Acute
Electrical Stimulation of the Paretic Upper Limb in the Early Stroke Phase
This study evaluates the effect of electrical somatosensory stimulation (ESS) on the restoration of upper limb functioning in acute stroke patients.
- Trial name
- NCT02250365
- Testing
- Continuous, suprasensory ESS, Intermittent, suprasensory ESS
- Where
- 3 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- University of Copenhagen
Stroke
Intranasal Insulin and Post-stroke Cognition: A Pilot Study
Almost two-thirds of survivors have cognitive impairment (CI), manifested as memory, language, and judgement problems. Post-stroke CI at 2 weeks is a significant predictor of long-term functional outcome, and more generally…
- Trial name
- NCT02810392
- Testing
- Intranasal Insulin, Intranasal saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Hyperglycaemia (Non Diabetic), Enteral Feeding Intolerance
Hyperglycemia in Patients with Stroke and Indication of Enteral Nutrition
The purpose of this study is to evaluate the effect of a specific nutritional formula for diabetics on the development of hyperglycemia in patients with recent non-diabetic stroke who require admission and enteral nutritional…
- Conditions
- Hyperglycaemia (Non Diabetic), Enteral Feeding Intolerance, Stroke
- Trial name
- GlyENStroke (NCT03422900)
- Testing
- Diabetes-Specific enteral formula, Standard formula
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Endocrinology and Clinical Nutrition Research Center, Spain
Brain Aneurysm
CLARYS: CLinical Assessment of WEB® Device in Ruptured aneurYSms
An observational non-randomized, multi-center, prospective assessment of the clinical utility of the WEB Aneurysm Embolization System in subjects with ruptured intracranial aneurysms deemed appropriate for endovascular treatment.
- Trial name
- CLARYS (NCT02687607)
- Testing
- WEB Aneurysm Embolization System
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Microvention-Terumo, Inc.
ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing…
- Trial name
- NCT05677607
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Traumatic Brain Injury, Subarachnoid Hemorrhage
Lactate Therapy After Traumatic Brain Injury
Background: Although glucose is essential to cerebral function, abundant experimental and clinical evidence demonstrates that endogenously released lactate, rather than glucose, is the preferential energy substrate for the brain…
- Trial name
- LS_TCC (NCT01573507)
- Testing
- sodium lactate infusion
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Stroke
Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome
The study aims to determine the effects of task-based mirror therapy on edema, pain and upper limb motor function with shoulder-hand syndrome in post stroke patients.
- Trial name
- NCT07428811
- Testing
- Task based mirror therapy, Conventional exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Acute Ischemic Stroke, Cerebral Infarction
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective…
- Trial name
- TREND-IVT (NCT06548971)
- Testing
- Aspirin, Best medical management
- Where
- 119 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Capital Medical University
Carotid Artery Diseases
A Multicenter Study of Ultrafast Pulse Wave Velocity in Obese Chinese Han Adults
Ultrafast pulse wave velocity (UFPWV) is a novel non-invasive method developed recently to evaluate pulse wave velocity (PWV). This multi-center clinical trial aims to evaluate the feasibility of UFPWV in the evaluation of the…
- Trial name
- NCT05455099
- Testing
- Carotid ultrasound examination 1, Carotid ultrasound examination 2
- Where
- 22 sites in China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
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