Clinical trials: Cerebrovascular Disorders
Inherited Mitochondrial Disease
A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease
The primary objective of this study is to assess the safety of vatiquinone in participants with inherited mitochondrial disease who had prior exposure to vatiquinone in a PTC/BioElectron sponsored (previously Edison) clinical…
- Trial name
- NCT05218655
- Testing
- Vatiquinone
- Where
- 26 sites in United States, France and 5 more
- Volunteers
- 101 people
- Sponsor
- PTC Therapeutics
Severe Stroke, Acute Stroke
Controlling Hypertension After Severe Cerebrovascular Event
The purpose of this academic lead study is to explore ideal blood pressure targets and optimum individualized anti-hypertension strategies in acute severe stroke.
- Conditions
- Severe Stroke, Acute Stroke, Hypertension
- Trial name
- CHASE (NCT02982655)
- Testing
- Individualized BP lowering
- Where
- 26 sites in China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital
Stroke, Transient Ischemic Attack
International PFO Consortium
The prevalence of patent foramen ovale (PFO) is about 25% in the general population and approximately 40% in patients who have ischemic stroke of unknown cause (cryptogenic stroke).
- Trial name
- NCT00859885
- Testing
- Antithrombotic treatment, percutaneous device closure of PFO
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 1,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Stroke, Thrombosis, Deep Vein
A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
To characterize and analyze the number, type and incidence of adverse events/suspected adverse drug reactions in patients treated with Apixaban, according to therapeutic indications approved in Mexico.
- Conditions
- Cerebral Stroke, Thrombosis, Deep Vein, Pulmonary Embolism
- Trial name
- NCT03804125
- Sponsor
- Pfizer
Stroke
Passive Robots for Stroke Rehabilitation: A Feasibility Study
The purpose of this study is to examine the feasibility and effectiveness of a novel, multimodal approach that combines passive devices with noninvasive neuromuscular stimulation for upper extremity rehabilitation after stroke.
- Trial name
- NCT07218276
- Testing
- Functional Training with SepaRRo and NeuRRoFES
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Michigan
Stroke
Comparison of Tele-rehabilitation Versus In-clinic Rehabilitation for Upper Limb Motor Function Stroke Patients
To determine the effects of Tele-rehabilitation versus in-clinical rehabilitation for upper limb motor function and spasticity in chronic ischemic stroke patients.
- Trial name
- NCT05875818
- Testing
- In-clinic Rehabilitation, Tele-rehabilitation
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Superior University
Ischemic Stroke
Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA
Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever large-vessel minor stroke or TIA compared to 300 mg clopidogrel were assessed…
- Trial name
- NCT06591338
- Testing
- Ticagrelor 90 MG, Clopidogrel, Aspirin 75 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Vascular Disease, Vascular Disease Risk
Effect of Atorvastatin (Lipitor) on Gene Expression in People With Vascular Disease
This study will determine if the drug Atorvastatin (Lipitor) changes the genetic material found in blood cells of people with vascular (blood vessel) disease.
- Trial name
- NCT00293748
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Stroke
Vibroacoustic Therap in Patients With Stroke
PURPOSE: to investigate the effect of vibroacoustic therapy device with laser motion guidance affect balance sensory integration in patients with stroke BACKGROUND: Following stroke, motor recovery can be dictated by the degree…
- Trial name
- NCT07206485
- Testing
- vibro-acoustic therapy, Motion Guidance Laser, selected physical therapy exercises program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October 6 University
Endocarditis, Bacterial, Aneurysm, Intracranial Mycotic
Neurological Complication of Infective Endocarditis: A Prospective Multi-site Cohort Study
The main objective of this study is to better estimate the rate of infectious intracranial aneurysms (IIA) in proved infective endocarditis (IE).
- Trial name
- NCT05152225
- Testing
- Brain MRI, digital subtraction angiography (DSA)
- Volunteers
- 200 people
- Sponsor
- the Jeunes en Neuroradiologie Interventionnelle (JENI) research group
Stroke, Ischemic, Atrial Fibrillation
Left Atrial Appendage Closure by Surgery-2
Atrial fibrillation is a heart rhythm disorder that often occurs after heart surgery. During atrial fibrillation blood cloths may form, predominantly in the left atrial appendage, a small sac in the wall of the left side of the…
- Trial name
- LAACS-2 (NCT03724318)
- Testing
- closure of the left atrium appendage
- Where
- 4 sites in Denmark, Spain and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Helena DOMINGUEZ
Stroke, Ischemic, Aphasia
pBFS-guided cTBS Over the Superior Temporal Gyrus for Aphasia After Ischemic Stroke
The objective of this trial is to evaluate the effectiveness and safeness of continuous Theta Burst Stimulation (cTBS) over the right Superior Temporal Gyrus (STG), guided by personalized Brain Function Sector (pBFS) technology…
- Trial name
- NCT05999318
- Testing
- active continuous Theta Burst Stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Changping Laboratory
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital
Severe Stroke
Delayed Versus Early Antihyperglycemic Treatment for Severe Stroke
This study is a exploratory, randomized, controlled, open-label, blinded-endpoint Phase II clinical trial designed to evaluate whether delaying antihyperglycemic treatment for 72 hours improves neurological outcomes in patients…
- Trial name
- NCT07501533
- Testing
- Intravenous insulin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Post-Stroke Spasticity, Cerebrovascular Accident
Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
This is a study to confirm the superior efficacy of GSK1358820 over placebo in patients with equinus deformity associated with post-stroke lower limb spasticity using the Modified Ashworth Scale (MAS) ankle score.
- Trial name
- NCT00460655
- Testing
- GSK1358820
- Where
- 20 sites in Japan
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Cerebrovascular Accident
Influence of Timing on Motor Learning
The purpose of this research study is to compare different methods for training hand movement at home after stroke. This study involves research because it will test two experimental devices, the MusicGlove and the Resonating Arm…
- Trial name
- NCT01769326
- Testing
- Conventional hand exercise, MusicGlove, Conventional Arm Exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Carotid Artery Stenosis
PMCF Study of Precise Pro Rx for Carotid Artery Disease
The purpose of this study is to evaluate long-term clinical safety and performance of the PRECISE PRO RX Nitinol Stent System to treat stenotic lesions of the carotid arteries.
- Trial name
- REAL-PRECISE (NCT07204678)
- Testing
- PRECISE PRO Rx Nitinol Stent System
- Where
- 4 sites in Austria, France and 1 more
- Volunteers
- 199 people
- Sponsor
- Cordis US Corp.
Subarachnoid Hemorrhage, Intracranial Hemorrhage
Enteral Nutrition and Glycemic Variability Neurological Intensive Care Unit Study
Primary Objective: To determine the effects of a diabetes specific enteral formula compared to a standard formula supplemented with protein (isocaloric and isonitrogenous) on the mean blood glucose and glycemic variability in a…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhage, Ischemic Strokes, Subdural Hematoma
- Trial name
- ANUS1014 (NCT01463878)
- Testing
- Glycerna, Jevity - Control Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Eastern Virginia Medical School